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Chemical Structure| 782480-50-6 Chemical Structure| 782480-50-6

Structure of 782480-50-6

Chemical Structure| 782480-50-6

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Product Details of [ 782480-50-6 ]

CAS No. :782480-50-6
Formula : C13H8ClFO
M.W : 234.65
SMILES Code : O=C(C1=CC=C(C=C1)C2=CC=C(C=C2)F)Cl

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Application In Synthesis of [ 782480-50-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 782480-50-6 ]

[ 782480-50-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2406-90-8 ]
  • [ 782480-50-6 ]
  • [ 892841-01-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine; In dichloromethane; at 20℃; Add oxalyl chloride (10 mL, 114.6 mmol) and DMF (4 drops) to a stirring suspension of4'-fluoro-biphenyl-4-carboxylic acid (4.9 g, 22.7 mmol) in CH2Cl2 (150 mL). Stir the reaction mixture at room temperature for 3 h. Concentrate the mixture in vacuo, add n-hexane, re- concentrate, and re-dissolve in CH2Cl2. Add the resultant 4'-fluoro-biphenyl-4-carbonyl chloride solution to a mixture of <strong>[2406-90-8]2-chloro-benzothiazol-6-ylamine</strong> (3.31 g, 17.9 mmol) and pyridine (3.0 mL) in CH2Cl2 (150 mL). Stir the reaction mixture overnight at room temperature. Dilute the reaction mixture with CH2Cl2. Wash the reaction mixture twice with LOM HCl and once with LOM NaOH. Dry the mixture over Na2SO4, concentrate in vacuo, and triturate with MeOH to yield the desired product (6.34 g, 93%). 1H NMR (400 MHz, DMSO-d6): deltaltheta.59 (s, IH), 8.69 (d, J = 1.6Hz, IH), 8.09 (d, J= 8.0Hz, 2H), 7.96 (d, J = 8.8Hz, IH), 7.87-7.79 (m, 5H), 7.38-7.31 (m, 2H).
 

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