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Chemical Structure| 79219-21-9 Chemical Structure| 79219-21-9

Structure of 79219-21-9

Chemical Structure| 79219-21-9

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Product Details of [ 79219-21-9 ]

CAS No. :79219-21-9
Formula : C13H18O
M.W : 190.28
SMILES Code : CCC(C1=CC=C(CCCC)C=C1)=O
MDL No. :MFCD09971929

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Application In Synthesis of [ 79219-21-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 79219-21-9 ]

[ 79219-21-9 ] Synthesis Path-Downstream   1~1

  • 1
  • hydrogen chloride-ethyl acetate [ No CAS ]
  • [ 79219-21-9 ]
  • [ 25150-61-2 ]
  • 4'-n-Butyl-2-methyl-3-pyrrolidinopropiophenone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With paraformaldehyde; In ethanol; ethyl acetate; EXAMPLE 3 4'-n-Butyl-2-methyl-3-pyrrolidinopropiophenone To a solution of 5.40 g of 4'-butylpropiophenone in 15 ml of ethyl acetate were added 3.00 g of <strong>[25150-61-2]pyrrolidine hydrochloride</strong>, 1.30 g of paraformaldehyde and 0.5 ml of 22% hydrogen chloride-ethyl acetate and the mixture was refluxed for 4.5 hours. After cooling, the reaction mixture was extracted with aqueous hydrochloric acid. The water layer was made alkaline with potassium carbonate and extracted with ether. The extract was washed with water, dried and evaporated. The residue was dissolved in ethanol and acidified with 40% ethanolic hydrogen chloride. The solution was evaporated and the residue was washed with isopropyl ether and then recrystallized from methyl ethyl ketone to give 2.93 g of hydrochloride of the desired compound as colorless scales, mp 116-117. Analysis for C18 H27 NO.HCl: Calculated %: C, 69.77; H, 9.11; N, 4.52; Found %: C, 69.51; H, 9.25; N, 4.55
 

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