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CAS No. : | 79432-87-4 | MDL No. : | MFCD00296965 |
Formula : | C10H9BrO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GPBINNSHRSTZQE-AATRIKPKSA-N |
M.W : | 241.08 | Pubchem ID : | 1482751 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With triethylamine; In water; N,N-dimethyl-formamide; at 90℃; for 16h; | General procedure: To a round-bottom flask catalyst 1a (0.1 mol%, 1 mg), alkene(1.5 mmol), aryliodide (1 mmol), triethylamine (2 mmol) andDMF/H2O (4 mL + 1 mL) were added. The reaction mixture was heated at 90C for 21 h. Then, the reaction mixture was cooled at room temperature, diluted with water and extracted withdichloromethane. The organic phase is evaporated under reducedpressure and the residue purified with a short plug of silica undervacuum using petroleum ether/ethyl acetate as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With sulfuric acid; at 70℃; for 3.5h;Reflux; | General procedure: In a round bottom flask, 4-methoxycinnamic acid (3.14 g, 17 mmol, 1 eq) was suspended in methanol (20 mL). Sulfuric acid (650 muL) was added dropwise. The reaction was brought to 70 C. and allowed to reflux for 3.5 hours, until starting material was consumed as observed by TLC. The crude reaction mixture was poured on ice water (30 mL). The organic products were extracted with ether (1*60 mL, 2*30 mL), washed with brine (30 mL) and dried using anhydrous MgSO4. The crude product was concentrated in vacuo. The desired (E)-methyl 3-(4-methoxyphenyl)acrylate was isolated by flash chromatography using 5:1 hexanes:ethyl acetate to afford a white solid in 96% yield (3.241 g). |
77% | With sulfuric acid; at 70℃; for 3.5h;Reflux; | General procedure: [0294] (E)-methyl 3-(4-methoxyphenyl)acrylate: In a round bottom flask, 4-methoxycinnamic acid (3.14 g, 17 mmol, 1 eq) was suspended in methanol (20 mL). Sulfuric acid (650 muL) was added dropwise. The reaction was brought to 70 C. and allowed to reflux for 3.5 hours, until starting material was consumed as observed by TLC. The crude reaction mixture was poured on ice water (30 mL). The organic products were extracted with ether (1×60 mL, 2×30 mL), washed with brine (30 mL) and dried using anhydrous MgSO4. The crude product was concentrated in vacuo. The desired (E)-methyl 3-(4-methoxyphenyl)acrylate was isolated by flash chromatography using 5:1 hexanes:ethyl acetate to afford a white solid in 96% yield (3.241 g). 1H NMR (300 MHz, CDCl3): delta7.61 (1H, d, J=15.9 Hz), 7.41 (2H, d, J=8.7 Hz), 6.84 (2H, d, J=8.7 Hz), 6.27 (1H, d, J=15.9 Hz), 3.83 (3H, s), 3.79 (3H, s). 13C NMR (75 MHz, CDCl3): delta167.8, 161.6, 144.6, 129.9, 127.2, 115.3, 114.4, 55.4, 51.6. |
57% | (d) Methyl trans-3-(3-bromophenyl)-2-propenoate (second method) Prepared in accordance with the above procedure using methyl diethyl phosphonoacetate to afford the title compound as white crystals (57%). Physical and spectroscopic data for this compound were as described above. |
Step A 3-(3-Bromo-phenyl)-acrylic acid methyl ester. A solution of 3-bromophenylacrylic acid (5.03 g), MeOH (75 mL), and concentrated HCl (1 mL) was heated at reflux for 3 h followed by stirring at room temperature for 20 h. Aqueous saturated NaHCO3 was added and the aqueous solution was washed with CH2Cl2 (2*). The organic solution was dried (MgSO4), filtered, and concentrated to provide the title ester of Step A (4.75 g). 1H NMR (400 MHz, CDCl3) delta 7.63-7.20 (m, 5H), 6.40 (d, 1H), 3.78 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Step B 3-(3-Cyano-phenyl)-acrylic acid methyl ester. The title compound was prepared from <strong>[79432-87-4]3-(3-bromo-phenyl)-acrylic acid methyl ester</strong> of Step A (4.75 g, 19.72 mmol) following the procedure described for Preparation 13, Step A with a reaction time of 5 h. Purification by medium pressure chromatography (9:1 hexanes:EtOAc) provided the title compound of Step B (3.05 g). 1H NMR (400 MHz, CDCl3) delta 7.75 (d, 1H), 7.70 (m, 1H), 7.64-7.60 (m, 2H), 7.49 (m, 1H), 6.46 (d, 1H), 3.80 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | EXAMPLE 2 Methyl 3-bromocinnamate Reaction of 3-bromocinnamic acid (22.72 g) with methyl lodide (21.3 g) as described in Example 1 gave the title ester (19.5 g, 81%) as a white solid mp (methanol) 62-65 C. upsilonmax (mull) 2920, 1725, 1640, 1560, 1465, 1315, 1200, 1170, 985, 865, and 790 cm-1, delta(CDCl3) 3.82 (3H, s, ester CH3), 6.36 (1H, d, J=16 Hz, C=CHCO2), 7.03-7.7 (4H, m, aromatic H), and 7.56 (1H, d, J=16 Hz, ArCH=). | |
47% | With sulfuric acid; In methanol; | (b) Methyl trans 3-(3-bromophenyl)-2-propenoate (first method) A solution of trans-3-(3-bromophenyl)-2-propenoic acid (0.405 mol) in methanol (300 ml) was treated with conc. sulfuric acid (6.0 ml) and heated under reflux for 10 h. The cooled mixture was filtered to afford the title compound (46.14 g, 47%) as brilliant white crystals, m.p. 53-55 C. (Found: C, 50.10; H, 3.58; Br; 33.21. C10 H9 BrO2 requires C, 49.82; H, 3.76; Br, 33.14%); numax (nujol)/cm-1 1730.5, 1715.0, 1644; deltaH (270 MHz) 3.81 (3H, s, OCH3); 6.43 (1H, d, 2-H, 3 J2,3 =16.2 Hz); 7.25 (1H, t, 5'-H, Jo =7.8 Hz); 7.43 (1H, dt, 4'-H, Jo =7.9, Jm =1.0 Hz); 7.50 (1H, dt, 6'-H, Jo =7.9, Jm =1.0 Hz); 7.60 (1H, d, 3-H, 3 J3,2 =16.2 Hz); 7.66 (1H, t, 2'-H, Jm =1.7 Hz). deltaC (67.8 MHz) 51.8 (OCH3); 123.0 (3'-C); 133.0 (4'-C); 136.4 (1'-C); 143.1 (3-C); 166.9 (CO2 Me). Remaining signals lie in the range 119.3-130.7 ppm; m/z 242.0, 240.0 (46.67, 47.64, M+), 211.0, 209.0 (72.69, 74.00), 182.9, 180.9 (15.67, 16.83), 161.0 (4.19), 130.0 (9.44), 102.1 (100). |
With chloro-trimethyl-silane; In methanol; | a Methyl m-bromocinnamate Trimethylsilyl chloride (5.6 ml) was added dropwise to a stirred solution of m-bromocinnamic acid (5.0 g, 22 mmol) in methanol (110 ml). After 4 h, the mixture was evaporated to give product as a white solid, M+ 242; 360 MHz 1H n.m.r (CDCl3) 7.67 (1H, s), 7.60 (1H, d, J 16 Hz), 7.50 (1H, d, J 7.9 Hz), 7.43 (1H, d, J 7.9 Hz), 7.26 (1H, d, J 15.6 Hz), 6.43 (1H, d, J 16.1 Hz), 3.81 (3H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; potassium carbonate;tetrakis(triphenylphosphine)palladium (0); In methanol; ethanol; toluene; | REFERENCE EXAMPLE 56 A suspension of methyl 3-bromocinnamate (3.8 g), phenyl borate (2.0 g), 1M potassium carbonate (20 ml) and ethanol (10 ml) in toluene(100 ml) was stirred under argon atmosphere at room temperature for 30 minutes. To the reaction mixture was added tetrakistriphenylphosphinepalladium (0.9 g), and the mixture was refluxed over night and extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column (ethyl acetate/hexane) to give colorless crystals (3.6 g), 1.8 g of which was dissolved in a solution of methanol (100 ml) and 1N sodium hydroxide (20 ml). The mixture was stirred at room temperature over night, concentrated, neutralized with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 3-phenylcinnamic acid (1.5 g) as colorless crystals. 1 H-NMR(delta ppm, CDCl3): 6.54 (1H, d, J=16.0 Hz), 7.39-7.67 (8H, m), 7.76-7.77 (1H,m), 7.87 (1H,d,J=16.0 Hz). IR(KBr) nu 1709 cm-1. Anal. for C15,H12 O2: Calcd. C,80.34; H,5.39. Found C,80.62; H,5.40. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; | REFERENCE EXAMPLE 54 To a mixture of 3-bromobenzaldehyde (10 g) and methoxy-carbonylmethylenetriphenylphosphine (20 g) was added toluene (150 ml), and the mixture was refluxed under nitrogen atmosphere for 2 hours. The solvent was evaporated, and the organic layer was washed with water and saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column (ethyl acetate/hexane) to give methyl 3-bromocinnamate (10.7 g) as colorless crystals. 1 H-NMR(delta ppm, CDCl3): 3.82 (3H, s), 6.44 (1H, d, J=16.0 Hz), 7.27 (1H, d, J=15.6 Hz), 7.43-7.54 (2H, m), 7.62 (1H, d, J=16.0 Hz), 7.66-7.68 (1H, m). IR(KBr) nu: 1734, 1717 cm-1. Anal. for C10 H9 BrO2: Calcd. C,49.82; H,3.76. Found C,49.90; H,3.90. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51.2 g (212 mmol, 96%) | In methanol; ethyl acetate; | A. 3-Bromocinnamic acid, methyl ester To a solution of 50.0 g (220 mmol, Aldrich) of 3-bromocinnamic acid in 1 L sieve-dried methanol (Burdick & Jackson), stirred at 0 C., was added dropwise a solution of acidic methanol (prepared by the addition of 2.5 mL acetyl chloride to 250 mL methanol). The reaction mixture was stirred at room temperature for 96 hours then concentrated in vacuo to give a crude green oil. The crude oil was flash-chromatographed (Merck silica, 100*200 mm, 1:1 ethyl acetate/hexane) to give 51.2 g (212 mmol, 96%) of ester A as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
sulfuric acid; for 5h;Reflux; | Example 10: Synthesis of trans-4-[3-(5-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4- c]pyridin-2-ylcarbamoyl)-phenyl]-pyrrolidine-3-carboxylic acid (3-cyano-phenyl)- amide fos-trifluoroacetic acid salt (Compound 17). 63 Add concentrated sulfuric acid (5.0 mL, 90 mmol) to a solution of 3-bromocinnamic acid (25.0 g, 110 mmol) in MeOH (250 mL). Heat the mixture to reflux for 5 h then cool to room temperature and concentrate under reduced pressure. Dilute the residue with water and extract with EtOAc. Concentrate the combined organic phase under reduced pressure and purify the residue by silica gel chromatography to provide 26 g of trans- - (3-bromo-phenyl)-acrylic acid methyl ester. | |
With sulfuric acid;Reflux; | General procedure: According to method I [2a, 3a, 6a, 9a,10a,12a,13a]: 15 mmols ofcinnamic acid were dissolved in 20 ml of dried methanol and 0.5 mlof concentrated sulfuric acid was added. Mixturewas refluxed from7 to 17 h. Next, the solvent was evaporated, residue was extractedwith 40 ml of ethyl acetate and washed with 0.5% NaOH and brine.Organic layer was dried with anhydrous sodium sulfate and solventwas evaporated again. When necessary, product was crystallizedfrom ethanol with addition of active carbon. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With trifluoroacetic acid; In dichloromethane; at 0℃; for 4h; | Add benzyl-methoxymethyl-trimethylsilanyl-amine (14.7 g, 2.20 mmol) to a solution of ira/is-S-Q-bromo-pheny^-acrylic acid methyl ester (10.0 g, 41.4 mmol) in methylene chloride (80 mL). Cool the mixture to 0 C and stir for 10 min then add trifluoroacetic acid (0.92 mL, 12.4 mmol) and stir the mixture at 0 C for an additional 4 h. Dilute the reaction mixture with water and extract with methylene chloride. Dry the combined organic phase over anhydrous sodium sulfate and concentrate under reduced pressure. Purify the residue by silica gel chromatography to provide 12 g (77%) of ira/is-l-benzyl- 4-(3-bromo-phenyl)-pyrrolidine-3-carboxylic acid methyl ester. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
49% | With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; palladium diacetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140℃; for 6h;Inert atmosphere; | To a stirred solution of the above-described MOM ether (300 mg, 1.89 mmol) in xylene (4.7 mL) were added methyl 3-(3-bromophenyl)acrylate (682 mg, 2.83 mmol), palladium acetate (32 mg, 0.141 mmol) and 1,1-bis(diphenylphosphino)ferrocene (627 mg, 1.13 mmol) and potassium tert-butoxide (317 mg, 2.83 mmol) at room temperature under argon atmosphere. After being stirred at 140 C for 6 h, the reaction mixture was cooled to room temperature and filtered through a pad of Celite. The filtrate was evaporated and purified by column chromatography on silica gel (CHCl3/MeOH, 140:1-100:1) to afford 31 as a brown viscous oil (296 mg, 49%). 1H NMR (300 MHz, CDCl3): delta 7.74-7.32 (m, 5H), 6.44 (d, J = 16.2 Hz, 1H), 4.56 (d, J = 6.6 Hz, 1H), 4.49 (d, J = 6.6 Hz, 1H), 4.39 (m, 1H), 3.81 (s, 3H), 3.64-3.50 (m, 2H), 3.25 (s, 3H), 2.75 (m, 1H), 2.54 (m, 1H), 2.35 (m, 1H), 2.16 (m, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Pd(dppf)Cl2; In N2; water; N,N-dimethyl-formamide; | 3-[3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]-acrylic acid methyl ester 12(ii) (R=Me, R'=Me) Pd(dppf)Cl2 (23 mg, 0.028 mmol), 5,5-dimethyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,3,2]dioxaborinane 3a (R=Me) (0.2 g, 0.64 mmol), K3PO4.2H2O (0.29 g, 1.16 mmol) and <strong>[79432-87-4]3-(3-bromophenyl)acrylic acid methyl ester</strong> (0.14 g, 0.54 mmol) were placed in a thick walled glass tube fitted with a Young's tap along with degassed DMF (10 mL) and H2O (2 mL) in a dry, N2 filled, glovebox. The mixture was heated at 80 C. until GCMS analysis showed the reaction to be complete (2 d). Dilute HCl(aq.) (2 mL) was added and the mixture was extracted with Et2O (3*10 mL). The organic phase was washed with dilute HCl(aq.) (3*10 mL), dried over MgSO4 and concentrated in vacuo. The mixture was filtered through a silica plug with hexane and then 10% DCM/hexane and the solvent was removed in vacuo. Recrystallisation from hot EtOH gave the product 12(ii) (R=Me, R'=Me) as a fluffy, white powder (0.17 g, 83%); mp 121-122. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 2h; | £)-3-(3-Bromophenyl)acrylic acid (3.00 g, 13.2 mmol) was dissolved in DMF (50 mL), Mel (3.75 g, 26.4 mmol) and K2C03 (2.74 g, 19.8 mmol) were added and the mixture was stirred for 2 h at rt. After insoluble salts were filtered and washed with EA, the solvent was washed with water (3 x 50 mL), brine (2 x 50 mL), dried over Na2S04, filtered and concentrated to give compound P16a as a yellow solid which was used in the next step without any purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With sodium methylate; In methanol; at 80 - 90℃; under 7500.75 Torr; for 7.5h;Reflux; Microwave irradiation; | General procedure: According to method II: 2.5 mmols of cinnamic acid ester and2.5 mmols of guanidine derivative were added to 3 ml of sodiummethoxide, fresh-prepared from 5 mmols of sodium and 3 ml ofdried methanol. The mixture was refluxed using microwave irradiationfrom 2 to 8 h in conditions: T 70e80 C; power 120 W;t0 10 min; t 60 min; p 5.0e6.0 bar. After the set time 15 ml ofwater was added to the mixture and stirred from 0.5 to 3 h. Theobtained precipitate was filtered and crystallized from methanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With palladium 10% on activated carbon; hydrogen; In methanol; at 40℃; for 6.0h; | To a dry flask were added (E) -methyl 3- (3-bromophenyl) acrylate (1.18 g, 4.89 mmol) , methanol (10 mL) and 10%Pd/C (120 mg) in turn, the mixture was stirred at 40 under H2for 6 hours. The mixture was filtered and the filtrate was concentrated in a rotary evaporator to get the title compound as a brown liquid (1.2 g, 100%) . ESI: (ESI, pos. ion) m/z: 243.1 [M+H]+. |
100% | With palladium 10% on activated carbon; hydrogen; In methanol; at 40℃; for 6.0h; | Methyl (E)-3-(3-bromophenyl)acrylate (1.18 g, 4.89 mmol) was added to the dry reaction vial.Methanol (10 mL) and 10% palladium on carbon (120 mg),The reaction was carried out at 40 C for 6 h under a hydrogen atmosphere.Filtration and the title compound was obtained as a brown liquid (1.2 g, 100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In water; for 12h;Reflux; | General procedure: Four synthetic mixtures constituted by 100 mg from each of the tests: 5, 6, 7, 8, 9, 10, 11, 12, 13 (Table I) are dissolved in 5 ml of methanol, ethanol, propanol and butanol respectively. 5 drops of concentrated hydrochloric acid (12N) are then added to each solution following by taking to reflux for 12 hours. The monitoring of the reaction is carried out by 1H NMR where a difference is observed in the chemical shifts between the protons of the salts with a dedicated task 12 and 1, as represented hereafter:After 12 hours, each solution is evaporated to dryness and the different mixtures are separately extracted with 3 times 15 ml of diethyl ether. The products extracted are then analyzed in MS-GPC, and the chromatograms corresponding to each mixture are presented below. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89.7% | In dichloromethane; at 0 - 20℃; for 8h; | To a dry flask were added 3-bromobenzaldehyde (1.01 g, 5.46 mmol) and DCM (15 mL) in turn, the mixture was stirred uniformly and cooled to 0 . And then methyl (triphenylphosphoranylidene) acetate (3.61 g, 10.8 mmol) was added, the mixture was stirred at rt for 8 hours. The mixture was concentrated in a rotary evaporator. The residue was purified by silica gel column chromatography (PE/EA (v/v) = 10/1) to give the title compound as a white solid (1.18 g, 89.7%) . ESI: (ESI, pos. ion) m/z: 241.10 [M+H]+. |
89.7% | In dichloromethane; at 0 - 20℃; for 8h; | 3-bromobenzaldehyde (1.01 g, 5.46 mmol) and DCM (15 mL) were added sequentially to a dry reaction flask.After stirring evenly, the temperature was lowered to 0 C.Add methoxyformylmethylenetriphenylphosphine (3.61 g, 10.8 mmol),It was then stirred at room temperature for 8 h. Spin-drying, the residue obtained was separated by silica gel column chromatography (PE/EA (V/V) = 10/1),The title compound was obtained as a white solid (1.18 g, 89.7%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 - 50℃;Inert atmosphere; | Under argon, NaH (60 %, 680 mg, 17.0 mmol) was initially charged in DMSO (30 mL) and trimethylsulphoxonium iodide (3.74 g, 17.0 mmol) was added in one portion at rt. After the evolution of gas had ceased, compound P16a (3.15 g, 13.1 mmol), dissolved in DMSO (10 mL), was slowly added drop-wise. After stirring overnight at 50C, the mixture was partitioned between EA and water. The aq. layer was extracted with EA. The combined organic layer was dried over Na2S04, filtered, concentrated and purified by FCC (EA:PE = 1 :20) to give compound P16 as a colorless oil |
Tags: 79432-87-4 synthesis path| 79432-87-4 SDS| 79432-87-4 COA| 79432-87-4 purity| 79432-87-4 application| 79432-87-4 NMR| 79432-87-4 COA| 79432-87-4 structure
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P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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