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Chemical Structure| 796120-81-5 Chemical Structure| 796120-81-5

Structure of 796120-81-5

Chemical Structure| 796120-81-5

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Product Details of [ 796120-81-5 ]

CAS No. :796120-81-5
Formula : C7H6F3NO2
M.W : 193.12
SMILES Code : OC1=CC=C(OCC(F)(F)F)N=C1
MDL No. :MFCD28963186
Boiling Point : No data available

Safety of [ 796120-81-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 796120-81-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 796120-81-5 ]

[ 796120-81-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 796120-81-5 ]
  • [ 34368-52-0 ]
  • (R)-3-[6-(2,2,2-trifluoroethoxy)pyridin-3-yloxy]pyrrolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃;Inert atmosphere; To a mixture of 6-(2,2,2-trifluoroethoxy)pyridin-3-ol (40 g), (S)-3-hydroxy-pyrrolidin-2-one (25.1 g) and PPh3 (70.6 g) in THF (600 mL) was added DIAD (50.2 g) dropwise at RT under nitrogen. The mixture was stirred at RT overnight. The solvent was removed, and the residue was purified by silica gel chromatography (DCM:MeOH=30:1) to remove most of the triphenylphosphine oxide side product. The product containing fractions were concentrated and redissolved in EA/PE (1:3, 200 mL). The solution was cooled (0° C.) in a refrigerator overnight. The white solid formed was filtered and washed with PE to provide (R)-3-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yloxy]-pyrrolidin-2-one. MS ESI+: m/z=277 [M+H]+.
 

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