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Chemical Structure| 80151-28-6 Chemical Structure| 80151-28-6

Structure of 80151-28-6

Chemical Structure| 80151-28-6

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Product Details of [ 80151-28-6 ]

CAS No. :80151-28-6
Formula : C9H7FO
M.W : 150.15
SMILES Code : OCC#CC1=CC=C(F)C=C1
MDL No. :MFCD04039232
InChI Key :ZROXSIPANMVWHB-UHFFFAOYSA-N
Pubchem ID :2782698

Safety of [ 80151-28-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 80151-28-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80151-28-6 ]

[ 80151-28-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 80151-28-6 ]
  • [ 154258-82-9 ]
YieldReaction ConditionsOperation in experiment
85% With N-iodo-succinimide; trifluorormethanesulfonic acid; acetic acid hydrazide; In 1,2-dichloro-ethane; at 83℃; for 5h;Sealed tube; The preparation process is as follows: adding a propargyl alcohol derivative, a halogen source and an acid in a sealed tube, and carrying out the reaction under the condition of heating under reflux at 83 C; and adding hydrazine after the propargyl alcohol derivative is completely disappeared by TLC monitoringAfter 5 hours of reaction, saturated brine was added to quench the reaction. The organic phase was extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated to obtain a pyrazole derivative. The purity of the product was improved by column chromatography, and the calculated yield was 85%. Among them, propargyl alcohol, halogen source, hydrazine, solvent and acid were added as 3- (4-fluorophenyl) prop-2-yn-1-ol (2mmol), NIS (2.4mmol), and acetylhydrazine (2.2 mmol), dichloroethane (35 mL) and trifluoromethanesulfonic acid (0.2 mmol).
 

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