808144-32-3|2,3-Difluorophenylacetyl chloride| Ambeed

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	808144-32-3
Formula :	C₈H₅ClF₂O
M.W :	190.57
SMILES Code :	O=C(Cl)CC1=CC=CC(F)=C1F
MDL No. :	MFCD12025021

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314-H290
Precautionary Statements:	P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Class:	8
UN#:	3265
Packing Group:	Ⅱ

Yield	Reaction Conditions	Operation in experiment
80%	With thionyl chloride; In dichloromethane; water;	1) Preparation of (2,3-difluorophenyl)acetyl chloride (1) 1.0 mole of <strong>[145689-41-4](2,3-difluorophenyl)acetic acid</strong> is dissolved in dichloromethane and 1.1 mole of thionyl chloride is added. The mixture is heated to 35 C. and stirred for 4 hours. After completion of the reaction, water is added. The resulting compound is extracted with dichloromethane, dried over MgSO4, and filtered. The solvent is evaporated to yield the target compound. (yield 80%) GC mass data: m/z 193 (>99%)
	With oxalyl dichloride;	Example 1 2-(2, 3-DIFLUORO-PHENYL)-1-(LN-PYRROLO [2, 3-B] PYRIDIN-3-Y L)-ETHANONE : Method A: (X =F) [0198] To 7-azaindole (1 g, 8.5 mmol) and AlCl3 (1.2 g, 9.0 mmol) in methlene chloride at 0C was added (2,3-difluorophenyl)-acetyl chloride [prepared by treating (2,3-difluoro-phenyl)-acetic acid (1.5 mg, 8.72 mmol) with oxalyl chloride (0.90 mL) ] in methlene chloride. After stirring at room temperature for 2 hours, the solution was poured into ice water and extracted with methlene chloride, dried (NA2S04), and concentrated to give 300 mg (13% yield) of title compound used without purification. LCMS Rt= 3. 00 minutes, MH 273.1, M-271. 1.

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P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
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CAS No.: 808144-32-3

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CAS No.: 808144-32-3

Alternative Products

Product Details of [ 808144-32-3 ]

Safety of [ 808144-32-3 ]

Application In Synthesis of [ 808144-32-3 ]

[ 808144-32-3 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed