808144-32-3|2,3-Difluorophenylacetyl chloride| Ambeed

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CAS No. :	808144-32-3
Formula :	C₈H₅ClF₂O
M.W :	190.57
SMILES Code :	O=C(Cl)CC1=CC=CC(F)=C1F
MDL No. :	MFCD12025021

Yield	Reaction Conditions	Operation in experiment
80%	With thionyl chloride; In dichloromethane; water;	1) Preparation of (2,3-difluorophenyl)acetyl chloride (1) 1.0 mole of <strong>[145689-41-4](2,3-difluorophenyl)acetic acid</strong> is dissolved in dichloromethane and 1.1 mole of thionyl chloride is added. The mixture is heated to 35 C. and stirred for 4 hours. After completion of the reaction, water is added. The resulting compound is extracted with dichloromethane, dried over MgSO4, and filtered. The solvent is evaporated to yield the target compound. (yield 80%) GC mass data: m/z 193 (>99%)
	With oxalyl dichloride;	Example 1 2-(2, 3-DIFLUORO-PHENYL)-1-(LN-PYRROLO [2, 3-B] PYRIDIN-3-Y L)-ETHANONE : Method A: (X =F) [0198] To 7-azaindole (1 g, 8.5 mmol) and AlCl3 (1.2 g, 9.0 mmol) in methlene chloride at 0C was added (2,3-difluorophenyl)-acetyl chloride [prepared by treating (2,3-difluoro-phenyl)-acetic acid (1.5 mg, 8.72 mmol) with oxalyl chloride (0.90 mL) ] in methlene chloride. After stirring at room temperature for 2 hours, the solution was poured into ice water and extracted with methlene chloride, dried (NA2S04), and concentrated to give 300 mg (13% yield) of title compound used without purification. LCMS Rt= 3. 00 minutes, MH 273.1, M-271. 1.

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P401
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Disposal
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H226	Flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
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H318	Causes serious eye damage
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H320	Causes eye irritation
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H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 808144-32-3

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CAS No.: 808144-32-3

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