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[ CAS No. 640735-23-5 ] {[proInfo.proName]}

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Chemical Structure| 640735-23-5
Chemical Structure| 640735-23-5
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Product Details of [ 640735-23-5 ]

CAS No. :640735-23-5 MDL No. :MFCD08272231
Formula : C7H5FN2 Boiling Point : -
Linear Structure Formula :- InChI Key :YZTWCWYRUCKWDR-UHFFFAOYSA-N
M.W : 136.13 Pubchem ID :11297998
Synonyms :

Safety of [ 640735-23-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338-P310 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 640735-23-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 640735-23-5 ]

[ 640735-23-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 74420-00-1 ]
  • [ 74420-02-3 ]
  • [ 640735-23-5 ]
  • 2
  • [ 640735-25-7 ]
  • [ 640735-23-5 ]
YieldReaction ConditionsOperation in experiment
94% With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20℃; for 1h;Inert atmosphere; [0722] To a stirred solution of 4-fluoro-i-(triisopropylsilyl)-1H-pyrrolo [2,3-bj pyridine (3 g, 10 mmol) in THF (15 mL) at 0 C under an argon atmosphere was added tetra butyl ammonium fluoride 1M in THF (10.5 mL). The reaction mixture was warmed to room temperature and stirred for 1 h. After consumption of starting material (by TLC), the reactionmixture was diluted with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 20%EtOAc: Hexane to afford 4-fluoro-1H-pyrrolo [2,3-bj pyridine (1.3 g, 94%) as an off-white solid. ?H NMR (CDC13, 400 MHz): 10.52 (brs, 1H), 8.30-8.25 (m, 1H), 7.32-7.30 (m, 1H), 6.81 (dd, 1H), 6.59 (s, 1H); TLC: 20% EtOAc Hexane (R 0.2).
  • 3
  • [ 109-01-3 ]
  • [ 640735-23-5 ]
  • 4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
  • 4
  • [ 31252-42-3 ]
  • [ 640735-23-5 ]
  • C19H21N3 [ No CAS ]
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