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Chemical Structure| 82100-30-9 Chemical Structure| 82100-30-9

Structure of 82100-30-9

Chemical Structure| 82100-30-9

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Product Details of [ 82100-30-9 ]

CAS No. :82100-30-9
Formula : C12H14N2O
M.W : 202.25
SMILES Code : O=C(C1=CC=CC=C1)C=C2NCCCN2
MDL No. :MFCD09266992

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Application In Synthesis of [ 82100-30-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82100-30-9 ]

[ 82100-30-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4139-61-1 ]
  • [ 82100-30-9 ]
  • [ 122-51-0 ]
  • [ 1634693-26-7 ]
YieldReaction ConditionsOperation in experiment
90% In neat (no solvent); at 50℃; for 0.166667h;Green chemistry; General procedure: HKA 1-3 (0.5 mmol), triethoxymethane 4 (1.0 mmol) and 4-hydroxycoumarin derivatives 5 (0.6 mmol) were charged into a 25 mL round-bottom flask and the mixture was heated to 50 C for about 10 minutes and monitored by TLC. Until the substrate HKA had been used up. Then reaction mixture was cooled to room temperature, filtered and washed with 95% EtOH to give the pure product in 83-95% yield. The products were further identified by FTIR, NMR and HRMS, and were in good agreemen twith the assigned structures.
  • 2
  • [ 720-94-5 ]
  • [ 82100-30-9 ]
  • [ 122-51-0 ]
  • (9-benzoyl-6-hydroxy-6-(trifluoromethyl)-2,3,4,6-tetrahydro-1H-pyrido[1,2-a]pyrimidin-7-yl)(p-tolyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% In neat (no solvent); for 2h;Reflux; Green chemistry; General procedure: HKAs 1 (1.0mmol), triethoxymethane 2 (3mmol), aryl substituted 4,4,4-trifluoro-1,3-butanedione 3 (1.1mmol) were placed into a 25mL round-bottom flask and the mixture was refluxed. The resulting solution was stirred for 2h until the HKAs 1 were completely consumed. The mixture was diluted with EtOAc (50mL×2) and quenched with water (50mL). The organic layer was dried by Na2SO4, concentrated, and purified by flash column chromatography (petroleum ether/EtOAc=3/1) to afford product 4a?4v with 79?93percent yield.
 

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