There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 823-39-2 | MDL No. : | MFCD02247162 |
Formula : | C7H10N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GJHFAHVMZHRUFR-UHFFFAOYSA-N |
M.W : | 122.17 | Pubchem ID : | 11007884 |
Synonyms : |
|
Num. heavy atoms : | 9 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.29 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 38.57 |
TPSA : | 38.91 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.17 cm/s |
Log Po/w (iLOGP) : | 1.46 |
Log Po/w (XLOGP3) : | 1.23 |
Log Po/w (WLOGP) : | 1.29 |
Log Po/w (MLOGP) : | 0.89 |
Log Po/w (SILICOS-IT) : | 1.54 |
Consensus Log Po/w : | 1.28 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.87 |
Solubility : | 1.66 mg/ml ; 0.0136 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.64 |
Solubility : | 2.77 mg/ml ; 0.0227 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.39 |
Solubility : | 0.493 mg/ml ; 0.00404 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.35 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P314-P321-P322-P330-P361-P363-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H311-H331-H373 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With sodium hydroxide In tetrahydrofuran; dichloromethane | EXAMPLE 2 Synthesis of N-tert-butyloxycarbonylphenylalaninol 4.55 g (120 mmol) of lithium aluminum hydride (Li(AlH4) was suspended in 210 ml of tetrahydrofuran to which 9.91 g (60 mmol) of (S)-(+)-phenylalanine was then carefully added. After adding (S)-(+)-phenylalanine, the mixture was heated to reflux at 90° C. for 6 hours, cooled to room temperature, added with 7.3 ml of 10percent aqueous sodium hydroxide solution and 9.1 ml of H2 O in sequence, and then stirred for 5 minutes. At the end of the stirring, a solution of 14.40 g (66 mmol) of di-tert-butyl bicarbonate and 200 mg (1.64 mmol) of dimethyl aminopyridine in 80 ml of methylene chloride was added. The mixture was heated to reflux at 70° C. for 6 hours, cooled to room temperature, filtered through a sodium sulfate (Na2 SO4) pad, and then washed with methylene chloride four times. Following the washing, an organic layer was concentrated under reduced pressure, and then recrystallized from methylene chloride-cyclohexane, thereby obtaining 11.31 g (75percent yield) of N-tert-butyloxy-carbonylphenylalaninol. 1 H NMR (CDCl3) δ 1.39(s, 9H), 2.85(d, J=7.2 Hz, 2H), 3.56(dd, J=10.8 Hz, J=5.4 Hz, 1H), 3.67 (dd, J=10.8 Hz, J=3.6 Hz, 1H), 3.88(m, 1H), 4.86(br s, 1H), 7.22-7.34(m, 5H); 13 C NMR (CDCL3) δ 28.3, 37.5, 53.7, 64.2, 79.7, 126.5, 128.5, 129.3, 137.8, 156.1 |
[ 875462-77-4 ]
3,4,5-Trimethylpyridin-2-amine
Similarity: 0.93
[ 199296-51-0 ]
4-(Aminomethyl)pyridin-2-amine
Similarity: 0.90
[ 875462-77-4 ]
3,4,5-Trimethylpyridin-2-amine
Similarity: 0.93
[ 199296-51-0 ]
4-(Aminomethyl)pyridin-2-amine
Similarity: 0.90
[ 42518-06-9 ]
Isonicotinimidamide xhydrochloride
Similarity: 0.86