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Chemical Structure| 82657-72-5 Chemical Structure| 82657-72-5

Structure of 82657-72-5

Chemical Structure| 82657-72-5

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Product Details of [ 82657-72-5 ]

CAS No. :82657-72-5
Formula : C13H11BrO
M.W : 263.13
SMILES Code : BrCC1=CC=CC=C1OC2=CC=CC=C2
MDL No. :MFCD01320513

Safety of [ 82657-72-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H302+H312+H332
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 82657-72-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82657-72-5 ]

[ 82657-72-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5932-27-4 ]
  • [ 82657-72-5 ]
  • [ 1253113-40-4 ]
YieldReaction ConditionsOperation in experiment
Intermediate 14: Ethyl 1 -U2-(phenyloxy)phenvpimethyl)-1H-pyrazole-3- carboxylate; To ethyl 1 H-pyrazole-3-carboxylate (1.05 g, 75 mmol, ChemCollect GmbH) in DMF (10 ml) under nitrogen was added sodium hydride (315 mg, 7.88 mmol) and the mixture stirred at room temperature for 10 min. To this mixture was added 1- (bromomethyl)-2-(phenyloxy)benzene (1.97 g, 7.5 mmol, Maybridge) and the mixture left to stir at room temperature for 1 h. The reaction quenched with water and extracted with ethyl acetate (3 x). The combined extracts were washed with -10percent lithium chloride solution in water (3 x), the organic layer dried over magnesium sulphate, the drying agent filtered off and the filtrate evaporated to dryness to leave an oil (2.55 g). This was applied to silica SPE (10Og) cartridge, eluting with DCIWEtOAc 0-50percent over 60 min. The pure fractions were combined and evaporated to dryness to leave the title compound as dark oil (2.1 g); LCMS: (System 4) MH+= 323, tRET = 3.08 min.
 

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