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Chemical Structure| 827042-59-1 Chemical Structure| 827042-59-1

Structure of 827042-59-1

Chemical Structure| 827042-59-1

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Product Details of [ 827042-59-1 ]

CAS No. :827042-59-1
Formula : C9H7ClN2O2
M.W : 210.62
SMILES Code : O=C(C1=NC2=C(C)C(Cl)=CC=C2N1)O

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Application In Synthesis of [ 827042-59-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 827042-59-1 ]

[ 827042-59-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 102877-78-1 ]
  • [ 827042-59-1 ]
  • N-[4-(pyridine-4-yloxy)phenyl]-5-chloro-4-methyl-1H-benzimidazole-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% 0.064 mmol of benzimidazolecarboxylic acid 4c was dissolved in DMF together with 0.064 MMO . of the amine 5a, a solution of TBTU (0.096 MMOL) in DMF, HOBT (0.026 MMOL) in DMF and 0.32 mmol of DIPEA were added successively, and the mixture was stirred at room temperature. After 2 hours, 0.3 eq. of acid was added, and the mixture was stirred for 2 hours. After further addition of 0.3 eq. of acid, the reaction mixture was diluted with water after 2 hours, and the resulting precipitate was filtered off with suction, washed with water and digested with diethyl ether and ethyl acetate. Yield : 96%, pale-beige solid
 

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