[ CAS No. 82957-06-0 ] {[proInfo.proName]}

Name: 82957-06-0|6-Hydroxy-2-naphthimidamide methanesulfonate salt|95%
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SKU: A185741
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Quality Control of [ 82957-06-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 82957-06-0 ]

SDS Specification

Alternatived Products of [ 82957-06-0 ]

Product Details of [ 82957-06-0 ]

CAS No. :	82957-06-0	MDL No. :	MFCD00143493
Formula :	C₁₂H₁₄N₂O₄S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	NLLGCELWCUFUFD-UHFFFAOYSA-N
M.W :	282.32	Pubchem ID :	135742414
Synonyms :

Calculated chemistry of [ 82957-06-0 ]

Physicochemical Properties

Num. heavy atoms :	19
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.08
Num. rotatable bonds :	1
Num. H-bond acceptors :	5.0
Num. H-bond donors :	4.0
Molar Refractivity :	74.69
TPSA :	132.85 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.79 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.78
Log Po/w (XLOGP3) :	0.33
Log Po/w (WLOGP) :	2.41
Log Po/w (MLOGP) :	1.28
Log Po/w (SILICOS-IT) :	1.74
Consensus Log Po/w :	1.31

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.12
Solubility :	2.13 mg/ml ; 0.00756 mol/l
Class :	Soluble
Log S (Ali) :	-2.68
Solubility :	0.585 mg/ml ; 0.00207 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.23
Solubility :	0.165 mg/ml ; 0.000585 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	3.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	1.66

Safety of [ 82957-06-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 82957-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 82957-06-0 ]
Downstream synthetic route of [ 82957-06-0 ]

[ 82957-06-0 ] Synthesis Path-Upstream 1~4

1
[ 52927-22-7 ]
[ 75-36-5 ]
[ 82957-06-0 ]

Yield	Reaction Conditions	Operation in experiment
53%	Stage #1: at 0 - 50℃; for 10 h; Stage #2: With methanesulfonic acid In methanol; tert-butyl methyl ether	Take 800 ml of absolute ethanol in three bottles,The mixture was cooled to 0-5 ° C with stirring and 430 ml of acetyl chloride was added dropwise.Dropping completed, at 0 ~ 5 for a period of time, put 6-cyano-2-naphthol 85 g, 10 ° C for 10 hours, methyl tert-butyl ether was added and stirred for 1 hour to filter,The filter cake was washed with methyl tert-butyl ether, dried and mixed directly with ethanol, heated to 50 ,Dry ammonia was bubbled for 3 hours and evaporated to dryness under reduced pressure to give a yellow solid.The mixture was stirred with saturated sodium bicarbonate solution for a period of time, filtered, washed with water until neutral.Wet products suspended in methanol, dropping a certain amount of methanesulfonic acid solution,Methyl tert-butyl ether was added to precipitate a solid, which was filtered, washed with methyl tert-butyl ether,Recrystallization from ethanol gave 75 g of a yellow solid,The temperature of 227 ° C ~ 230 ° C,Yield 53percent.

Reference： [1] Patent: CN103896809, 2017, B, . Location in patent: Paragraph 0010; 0011; 0012; 0013

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Reference： [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 4, p. 1458 - 1471

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Reference： [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 4, p. 1458 - 1471

[ 82957-06-0 ] Synthesis Path-Downstream 1~88

1
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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

2
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5
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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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7
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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

10
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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

27
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[ 82957-06-0 ]
4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with carbonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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33
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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

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Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 1458 - 1471

39
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4-(N'-Acetyl-guanidino)-benzoic acid [ No CAS ]
4-(N'-Acetyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

40
[ 82957-06-0 ]
4-(1-methylguanidino)benzoic acid hydrochloride [ No CAS ]
4-(N-Methyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

41
[ 82957-06-0 ]
4-(N'-Methyl-guanidino)-benzoic acid; hydrochloride [ No CAS ]
4-(N'-Methyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; hydrochloride [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

42
[ 82957-06-0 ]
4-(N',N''-Dimethyl-guanidino)-benzoic acid; hydrochloride [ No CAS ]
4-(N',N''-Dimethyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

43
[ 82957-06-0 ]
4-(3,3-dimethylguanidino)benzoic acid hydrochloride [ No CAS ]
4-(N',N'-Dimethyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

44
[ 82957-06-0 ]
4-(1H-Imidazol-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(1H-Imidazol-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; hydrochloride [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

45
[ 82957-06-0 ]
4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoic acid hydrochloride [ No CAS ]
6-amidino-2-naphthyl 4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoate dihydrochloride [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

46
[ 82957-06-0 ]
4-(2-amino-1-imidazolynyl)benzoic acid hydrochloride [ No CAS ]
4-(2-Amino-4,5-dihydro-imidazol-1-yl)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; hydrochloride [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

47
[ 82957-06-0 ]
4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

48
[ 82957-06-0 ]
4-(5-Methyl-4,5-dihydro-1H-imidazol-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(5-Methyl-4,5-dihydro-1H-imidazol-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

49
[ 82957-06-0 ]
4-(1-Methyl-4,5-dihydro-1H-imidazol-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(1-Methyl-4,5-dihydro-1H-imidazol-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

50
[ 82957-06-0 ]
4-(1H-Benzoimidazol-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(1H-Benzoimidazol-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; hydrochloride [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

51
[ 82957-06-0 ]
4-(3a,4,5,6,7,7a-Hexahydro-1H-benzoimidazol-2-ylamino)-benzoic acid; hydrochloride [ No CAS ]
4-(3a,4,5,6,7,7a-Hexahydro-1H-benzoimidazol-2-ylamino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

52
[ 82957-06-0 ]
4-(N'-Benzoyl-guanidino)-benzoic acid; hydrochloride [ No CAS ]
4-(N'-Benzoyl-guanidino)-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

53
[ 82957-06-0 ]
2-amino-5-carboxy benzimidazole methanesulfonate [ No CAS ]
2-Amino-3H-benzoimidazole-5-carboxylic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

54
[ 82957-06-0 ]
4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoic acid methanesulfonate [ No CAS ]
[ 103926-82-5 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 117 - 125

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67
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(+-)-1-<α-piperidino-benzyl>-<2>naphthol [ No CAS ]
[ 82957-06-0 ]

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[ 82956-51-2 ]

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[ 82957-06-0 ]
[ 84729-92-0 ]

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[ 60-29-7 ]
[ 82957-06-0 ]
[ 75-36-5 ]
[ 84729-68-0 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; methanesulfonic acid; In methanol; water;	EXAMPLE 1 Synthesis of 6-amidino-2-naphthyl acetate (Compound No. 1) STR6 To 50 ml of anhydrous pyridine, was added 5.0 g of <strong>[82957-06-0]6-amidino-2-naphthol methanesulfonate</strong>. To the mixture, while being stirred and cooled in ice, was added slowly dropwise 1.4 g of acetyl chloride. The mixture was stirred for 3 hours at room temperature and poured into stirred ethyl ether. The crystals were collected by filtration, washed with ethyl ether, dissolved in water, and poured into saturated aqueous sodium bicarbonate solution. The precipitated crystals were collected by filtration, washed with water, then with acetone, and dried to obtain 2.3 g of the carbonate of captioned compound. The salt was suspended in 20 ml of methanol. To the suspension, while being cooled in ice, was added 1.3 equivalents of methanesulfonic acid followed by ethyl ether to yield 1.7 g of white to pale brown crystals of 6-amidino-2-naphthyl acetate methanesulfonate. Melting point: ca. 204 C. IR numaxKBr cm-1: 3275, 3080, 1760, 1670. NMR (DMSO-d6) delta: 2.35 (3H, s), 2.43 (3H, s), 7.33-8.63 (6H, m), 8.87-9.67 (4H, br).

Reference： [1]Patent: US4496584,1985,A

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[ 60-29-7 ]
[ 144-55-8 ]
[ 4023-34-1 ]
[ 82957-06-0 ]
[ 84729-81-7 ]

Yield	Reaction Conditions	Operation in experiment
	With methanesulfonic acid; In pyridine; methanol; water;	EXAMPLE 10 Synthesis of 6-amidino-2-naphthyl cyclopropanecarboxylate (Compound No. 10) STR15 To a solution of 5.0 g of <strong>[82957-06-0]6-amidino-2-naphthol methanesulfonate</strong> in 50 ml of anhydrous pyridine, while being cooled in ice, was added dropwise with stirring 1.9 g of cyclopropanecarbonyl chloride. The mixture was stirred overnight at room temperature, and the insolubles were separated and washed with a small volume of pyridine. The filtrate and the washings were poured into stirred ethyl ether. The crystals were collected by filtration, washed with ethyl ether, dissolved in water, and poured into stirred saturated aqueous sodium bicarbonate solution. The precipitated crystals were collected by filtration, washed with water, then with acetone, and dried to obtain 3.4 g of the carbonate of the captioned compound. To a suspension of the salt in 20 ml of methanol, while being cooled in ice, was added 1.2 equivalents of methanesulfonic acid followed by ethyl ether to obtain 3.0 g of white granular crystals of 6-amidino-2-naphthyl cyclopropanecarboxylate methanesulfonate. Melting point: 214-217 C. IR numaxKBr cm-1: 3270, 3120, 1745, 1675 NMR (DMSO-d6) delta: 1.13 (4H, m), 2.02 (1H, m), 2.45 (3H, s), 7.37-8.57 (6H, m), 9.33 (4H, br).

Reference： [1]Patent: US4496584,1985,A

77
[ 42823-46-1 ]
[ 82957-06-0 ]
C₁₉H₁₇N₅O₂*CH₄O₃S*ClH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; dmap; diisopropyl-carbodiimide; at 20℃;	At room temperature25.94 g of <strong>[42823-46-1]4-guanidinobenzoic acid hydrochloride</strong> (4-GDA.HCl) was added to 207.5 ml of pyridine solvent, 18.6 ml of N, N'-diisopropylcarbodiimide (DIC) was added and reacted. to the next, to the reaction solution comprising the above reaction, 28.3 g of 6-amidino-2-naphthol methanesulfonate (6-ANL.MsOH) and 122 mg of 4-dimethylaminopyridine (DMAP) The mixture was stirred overnight at the same temperature as that of the reaction. next, methanol (MeOH) (69.3 ml) was added to the reaction mixture which had been stirred, stirred for 1 hour, filtered, Subsequently, the compound of Formula 1 purified by a purity of 99% by a further purification process, in that not dry, saturated sodium in 233.28 ml of water (H2O) and 92.73 ml for 1 hour at a temperature of 25 C bicarbonate (NaHCO3) is added slowly to a mixed solution (solvent), and the crystal precipitates and stirred, after it was filtered, using a water and acetone by washing sequentially, the compound (purity according to the general formula (2): 98.9% ) was prepared. To the next, the compound of formula (2) Without drying, after the mixture was dispersed in 72.87 ml of methanol while maintaining the temperature at room temperature,9.3 ml of methanesulfonic acid (MsOH) was slowly added, The mixture was continuously stirred until no gas was generated. Then, it was cooled to 15 DEG C, After stirring for 10 minutes at the same temperature, the resulting solid was filtered,Washed sequentially with methanol and acetone,By hot air drying at a temperature of 50C, by drying (Purity: 99.1%, yield: 62.78%) of the nafamostat mesilate according to the above formula (3).

Reference： [1]Patent: KR101595747,2016,B1 .Location in patent: Paragraph 0054; 0055

78
[ 82957-06-0 ]
C₂₀H₁₉N₃O₃ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

79
[ 82957-06-0 ]
C₃₄H₃₇N₅O₆ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

80
[ 82957-06-0 ]
C₃₉H₄₅N₅O₈ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

81
[ 82957-06-0 ]
C₄₆H₆₁N₉O₈ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

82
[ 82957-06-0 ]
C₃₁H₃₉N₅O₆ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

83
[ 82957-06-0 ]
C₅₀H₆₅N₇O₁₁ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

84
[ 82957-06-0 ]
C₄₂H₅₉N₇O₉ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

85
[ 82957-06-0 ]
C₆₁H₈₅N₉O₁₄ [ No CAS ]

Reference： [1]Patent: US2017/100390,2017,A1

86
[ 82957-06-0 ]
[ 168892-66-8 ]
C₂₅H₂₇N₃O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; dicyclohexyl-carbodiimide;	A solution of compound E (Mesylate salt, 10.0 g, 35.5 mmol), 4-(2-((tert-butoxycarbonyl)amine)ethoxy) benzoic acid (10.0 g, 35.5 mmol) and DCC (11.0 g, 53.3 mmol) in pyridine (100 mL) was stirred overnight. Solvent was evaporated in vacuo. The residue was then dissolved in 4N hydrogen chloride in 1,4-dioxane (100 mL). After 1 h, solvent was removed under vacuum until about 50 mL remained. Diethyl ether (500 mL) was added to the reaction mixture, which produced an off-white/light tan precipitate. The precipitate was filtered off, washed with ether (3×150 mL) and dried under vacuum to give an off-white solid. The crude product triturated in acetone, followed by trituration in MTBE, filtered and dried to afford an off-white/light tan precipitate (11.1 g, 74%). LC-MS, [M+H] 350.4 (C20H19N3O3+H, calc: 350.1). The crude product was used without additional purification.

Reference： [1]Patent: US2017/100390,2017,A1 .Location in patent: Paragraph 1115

87
[ 52927-22-7 ]
[ 75-36-5 ]
[ 82957-06-0 ]

Yield	Reaction Conditions	Operation in experiment
53%		Take 800 ml of absolute ethanol in three bottles,The mixture was cooled to 0-5 C with stirring and 430 ml of acetyl chloride was added dropwise.Dropping completed, at 0 ~ 5 for a period of time, put <strong>[52927-22-7]6-cyano-2-naphthol</strong> 85 g, 10 C for 10 hours, methyl tert-butyl ether was added and stirred for 1 hour to filter,The filter cake was washed with methyl tert-butyl ether, dried and mixed directly with ethanol, heated to 50 ,Dry ammonia was bubbled for 3 hours and evaporated to dryness under reduced pressure to give a yellow solid.The mixture was stirred with saturated sodium bicarbonate solution for a period of time, filtered, washed with water until neutral.Wet products suspended in methanol, dropping a certain amount of methanesulfonic acid solution,Methyl tert-butyl ether was added to precipitate a solid, which was filtered, washed with methyl tert-butyl ether,Recrystallization from ethanol gave 75 g of a yellow solid,The temperature of 227 C ~ 230 C,Yield 53%.

Reference： [1]Patent: CN103896809,2017,B .Location in patent: Paragraph 0010; 0011; 0012; 0013

88
3-guanidino-benzoic acid hydrochloride [ No CAS ]
[ 82957-06-0 ]
C₁₉H₁₇N₅O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; dicyclohexyl-carbodiimide; In pyridine; at 20℃; for 24.0h;	The 3.4g (0.0158mol) 3- guanidino-benzoic acid hydrochloride,3.8g (0.0135mol) 6-fluorenyl-2-naphthol mesylate,3.4gN, N'-dicyclohexylcarbodiimide (dehydrating agent),0.02g of 4-dimethylaminopyridine (catalyst) and 50ml of pyridine were added to the reaction flask and the reaction was stirred at room temperature for 24 hours.Filter, add the filter cake to 100ml of water and stir, filter out insoluble matter,The filtrate was added dropwise with a 0.1 mol / L sodium bicarbonate solution to adjust the pH to 8, a solid was precipitated, filtered, dried,This gives 6-fluorenyl-2-naphthyl-3-guanidinobenzoate.

Reference： [1]Patent: CN110330447,2019,A .Location in patent: Paragraph 0053; 0060-0064

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A185083[ 58200-88-7 ]

6-Hydroxy-2-naphthimidamide

Reason: Free-salt

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H205	May mass explode in fire
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H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H290	May be corrosive to metals
Health hazards
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H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
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H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
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Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ 82957-06-0 ] Synthesis Path-Upstream 1~4

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