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Chemical Structure| 83190-02-7 Chemical Structure| 83190-02-7

Structure of 83190-02-7

Chemical Structure| 83190-02-7

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Product Details of [ 83190-02-7 ]

CAS No. :83190-02-7
Formula : C8H9F2NO
M.W : 173.16
SMILES Code : NC1=CC=C(OC(F)F)C(C)=C1
MDL No. :MFCD18389547

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Application In Synthesis of [ 83190-02-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 83190-02-7 ]

[ 83190-02-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 83190-02-7 ]
  • [ 888327-32-0 ]
YieldReaction ConditionsOperation in experiment
37% 4-Bromo-l-difluoromethoxy-2-niethyl-benzene:; To a stirred solution of 4-amino-l-difluoromethoxy-2- methyl -benzene (5 g, 28.90 mmol) in HBr (20 mL) and water (20 mL) at 0C was added a solution of sodium nitrite (2.07 g, 30.00 mmol) in H2O (10 ml) dropwise over a period of 20 minutes. After the addition was complete, the reaction mixture was stirred for 30 minutes at 0C. Copper (I) bromide (4 g, 27.87 mmol) was then added and the mixture was heated at 60C for 30 minutes. The resulting solution was extracted with EtOAc (3 X 50 mL) and the combined organic layers washed with H2O (IX 2OmL), dried over Na2Stheta4 and concentrated to provide 2.5 g (37 %) of 4-bromo-l-(difluoromethoxy)-2- methylbenzene
 

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