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Chemical Structure| 834906-31-9 Chemical Structure| 834906-31-9

Structure of 834906-31-9

Chemical Structure| 834906-31-9

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Product Details of [ 834906-31-9 ]

CAS No. :834906-31-9
Formula : C24H24O4
M.W : 376.45
SMILES Code : COC1=CC=C(C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4OC4)C=C1

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Application In Synthesis of [ 834906-31-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 834906-31-9 ]

[ 834906-31-9 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 13093-04-4 ]
  • [ 834906-31-9 ]
  • C32H44N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; To a stirred solution of N1,N6-dimethylhexane-1,6-diamine 143 (4.225 g, 29 mmol) and K2C03 (0.15 g, 1 mmol) dissolved in DMF and heated to 90 C was added drop-wise compound 142 (5.06 g, 13.5 mmol). The reaction mixture was stuffed overnight until no compound 142 remained. The reaction was quenched with ice, extracted with DCM, dried over Na2SO4, and purified by column chromatography using a gradient of DCM (2.5% NEt3) MeOH (30%) to afford 7.8 g (63%) of pure compound 144. ?H NMR (500 MHz, DMSO-d6): oe 7.40 (d,= 7.6 Hz, 2H), 7.35 - 7.14 (m, 7H), 6.88 (d, I = 8.5 Hz, 4H), 4.12 (s, 1H), 3.80 - 3.64 (s, 6H), 3.37 (m, 2H), 3.11 -2.89 (m, 5H), 2.85 (dt, I = 15.1, 7.6 Hz, 1H), 2.82-2.76 (m, 2H), 2.69 (s, 3H), 2.48 - 2.38 (s, 3H), 1.61 (m, 4H), 1.28 (m, 4H). ?3C NMR (DMSO-d6): oe 158.03, 144.82,135.54, 135.48, 129.72, 127.79, 127.69, 126.63, 113.15, 85.41, 65.77, 64.74, 58.49, 55.03, 54.92,52.02, 47.83, 45.17, 40.00, 39.92, 39.83, 39.76, 39.66, 39.50, 39.33, 39.16, 39.00, 32.11, 25.50,25.40, 24.99, 23.29, 8.37, 7.23.
  • 3
  • [ 13093-04-4 ]
  • [ 834906-31-9 ]
  • C32H44N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% In neat (no solvent); at 110℃; for 0.5h;Microwave irradiation; The commercially available (R)-glycidol was converted to the ODMTr protected epoxide 220 as reported in the literature. Treatment of the epoxide 220 (1.12 g, 3 mmol) with the 1,6- dimethylaminohexane 221 (6 mmol, 2eq.) at 110 C under microwave irradiation for 30 mm provided the epoxide opened product 222 in 90% yield.
 

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