13093-04-4|N1,N6-Dimethylhexane-1,6-diamine| Ambeed

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Quality Control of [ 13093-04-4 ] Purity: 98% SDS Specification

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Product Citations

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing ; Gordon, Akiva ; Jiang, Allen ; Varley, Andrew , et al.

DOI: 10.1038/s41587-023-01679-x PubMed ID: 36997680 Nat. Biotechnol.,2023,41(10):1410-1415.

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

Purchased from AmBeed: 14916-80-4 ; 294-90-6 ; 13093-04-4 ; 65604-89-9 ; 22366-98-9 ; 143-28-2 ; 1484-84-0 ; 112-92-5 ; 3433-37-2 ; 34803-66-2 ; 622-26-4 ; 934-98-5 ; 3529-08-6 ; 123-70-6 ; 23356-96-9 ; 534-26-9 ; 20739-58-6 ; 4730-54-5 ; 108-00-9 ; 51388-00-2 ; 6711-48-4 ; 7209-38-3 ; 506-43-4 ; 2038-03-1 ; 142-25-6 ; 27578-60-5 ; 105-83-9 ; 67980-77-2 ; 877-96-3 ; 14712-23-3 ; 4572-03-6 ; 14156-95-7 ; 10563-26-5 ; 4097-88-5 ; 111-33-1 ; 123-12-6 ; 6261-22-9 ; 496808-04-9 ; 3644-18-6 ; 764-60-3 ; 1002-36-4 ; 51-45-6 ; 112086-54-1 ; 22104-79-6 ; 67529-83-3 ; 10563-29-8 ; 294-90-6 ; 506-43-4 ; 13901-38-7 ; 938459-02-0 ; 51721-39-2 ; 18128-28-4 ; 915922-79-1 ; 205059-32-1 ; 5298-72-6 ; 22763-69-5

Product Details of [ 13093-04-4 ]

CAS No. :	13093-04-4
Formula :	C₈H₂₀N₂
M.W :	144.26
SMILES Code :	CNCCCCCCNC
MDL No. :	MFCD00008293
InChI Key :	MDKQJOKKKZNQDG-UHFFFAOYSA-N
Pubchem ID :	83131

Safety of [ 13093-04-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H227-H315-H319-H335
Precautionary Statements:	P210-P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 13093-04-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 13093-04-4 ]

[ 13093-04-4 ] Synthesis Path-Downstream 1~35

1
[ 75-15-0 ]
[ 13093-04-4 ]
[ 109254-97-9 ]

References: [1]Annales de Chimie (Cachan, France),1958,vol. <13>3,p. 599,631.

2
[ 75-15-0 ]
[ 13093-04-4 ]
[ 75854-55-6 ]

References: [1]Recueil des Travaux Chimiques des Pays-Bas,1951,vol. 70,p. 949,959.

3
[ 75-44-5 ]
[ 13093-04-4 ]
[ 110571-18-1 ]

References: [1]Patent: US2789981,1953, .

4
[ 3397-62-4 ]
[ 13093-04-4 ]
[ 109337-19-1 ]

References: [1]Journal of Pharmacy and Pharmacology,1959,vol. 11,p. 80,86.

5
[ 13093-04-4 ]
[ 2834-05-1 ]
11-[methyl-(6-methylamino-hexyl)-amino]-undecanoic acid [ No CAS ]

References: [1]Annales de Chimie (Cachan, France),1951,vol. <12>6,p. 53,67.

6
[ 13093-04-4 ]
[ 1940-57-4 ]
[ 63834-53-7 ]

References: [1]Journal of the American Chemical Society,1954,vol. 76,p. 1862,1865.

7
[ 102600-37-3 ]
[ 13093-04-4 ]

References: [1]Justus Liebigs Annalen der Chemie,1958,vol. 611,p. 71,78.

8
[ 13093-04-4 ]
[ 541-41-3 ]
[ 67549-12-6 ]

References: [1]Journal of the American Chemical Society,1957,vol. 79,p. 5717,5718.

9
[ 3009-40-3 ]
[ 77-78-1 ]
[ 13093-04-4 ]

References: [1]Journal of Polymer Science,1959,vol. 40,p. 343,345.
[2]Bulletin de la Societe Chimique de France,1968,p. 3275 - 3280.

10
[ 629-03-8 ]
[ 74-89-5 ]
[ 13093-04-4 ]

References: [1]Patent: US2334782,1941, .

11
[ 111-25-1 ]
[ 13093-04-4 ]
[ 71181-77-6 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

12
[ 111-83-1 ]
[ 13093-04-4 ]
[ 58295-98-0 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

13
[ 693-58-3 ]
[ 13093-04-4 ]
[ 71181-83-4 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

14
[ 693-58-3 ]
[ 13093-04-4 ]
[ 71181-78-7 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

15
[ 112-29-8 ]
[ 13093-04-4 ]
[ 71181-84-5 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

16
[ 112-29-8 ]
[ 13093-04-4 ]
[ 71181-79-8 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

17
[ 13093-04-4 ]
[ 765-09-3 ]
[ 71181-87-8 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

18
[ 13093-04-4 ]
[ 765-09-3 ]
[ 71181-81-2 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

19
[ 13093-04-4 ]
[ 112-71-0 ]
[ 71181-88-9 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

20
[ 13093-04-4 ]
[ 112-71-0 ]
[ 71181-82-3 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

21
[ 13093-04-4 ]
[ 629-72-1 ]
[ 71181-89-0 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

22
[ 1740-58-5 ]
[ 13093-04-4 ]

References: [1]Journal of the Chemical Society,1963,p. 846 - 853.

23
[ 13093-04-4 ]
[ 1675-54-3 ]
[ 30215-97-5 ]

References: [1]Acta Chemica Scandinavica (1947),1970,vol. 24,p. 2397 - 2407.

24
[ 13093-04-4 ]
[ 143-15-7 ]
[ 58295-87-7 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

25
[ 13093-04-4 ]
[ 143-15-7 ]
[ 71181-86-7 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

26
[ 124-09-4 ]
[ 77-78-1 ]
[ 13093-04-4 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

27
[ 13093-04-4 ]
[ 112-82-3 ]
[ 71181-90-3 ]

References: [1]Collection of Czechoslovak Chemical Communications,1979,vol. 44,p. 773 - 780.

28
[ 75-15-0 ]
[ 13093-04-4 ]
[ 78382-97-5 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 1089 - 1092.

29
[ 75-44-5 ]
[ 13093-04-4 ]
[ 99191-71-6 ]

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 228 - 236.

30
[ 527-69-5 ]
[ 13093-04-4 ]
[ 116784-90-8 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane; at 0℃; for 2h;	2-Furanoyl chloride (3.75 mL, 38 mmol) was added dropwise, at 0 C., to a mixture of N-tert-butoxycarbonyl-<strong>[13093-04-4]N,N'-dimethyl-1,6-hexanediamine</strong> (9.3 g, 38 mmol) and triethylamine (8.4 mL, 60 mmol) in dichloromethane (120 mL). The resulting mixture was stirred (2 h). The reaction mixture was washed with water (2×20 mL), brine (20 mL), dried over Na2SO4, and concentrated under reduced pressure. The residue was treated with 50% trifluoroacetic acid/dichloromethane (100 mL) overnight. Trifluoroacetic acid and dichloromethane were removed under reduced pressure and the residue was azeotroped with toluene (50 mL). The residue was dissolved in dichloromethane (120 mL), treated carefully with excess NaHCO3 (aqueous), the organic layer separated and the aqueous layer extracted with dichloromethane (2×50 mL). The combined organic layers were washed with water, brine and dried over Na2SO4. After removing the solvent, the residue was dried under vacuum to give the desired product 10 (7.8 g). MH+ 239.2, 1H NMR (CDCl3) delta7.50 (s, 1H), 7.0 (d, 1H), 6.50 (d, 1H), 3.55 (br. s, 3H), 3.0-3.3 (m, 4H), 2.4 5(s, 3H), 1.35-1.75 (m, 8H).

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 50 - 55.
[2]Patent: US6355641,2002,B1 .Location in patent: Page column 32.

31
[ 13093-04-4 ]
[ 31250-16-5 ]
[ 89806-89-3 ]

References: [1]Tetrahedron,1984,vol. 40,p. 1009 - 1016.

32
[ 13093-04-4 ]
[ 62442-57-3 ]
1,6-bis-N,N'-dimethyl-N,N'-(4'-methylen-4,5',8-trimethylpsoralenyl)hexandiamine [ No CAS ]

References: [1]Il Farmaco,1993,vol. 48,p. 835 - 855.

33
[ 13093-04-4 ]
[ 58537-73-8 ]
[ 148918-71-2 ]

References: [1]Journal of Organic Chemistry,1993,vol. 58,p. 2573 - 2577.

34
[ 13093-04-4 ]
[ 117688-86-5 ]
[ 117688-88-7 ]

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 228 - 236.

35
[ 13093-04-4 ]
[ 154798-96-6 ]
C₈₃H₂₉N₃O₃ [ No CAS ]

References: [1]Angewandte Chemie,1994,vol. 106,p. 601 - 603.

Precautionary Statements-General
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Response
Code	Phrase
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P321
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P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
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H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 13093-04-4

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CAS No.: 13093-04-4

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Product Details of [ 13093-04-4 ]

Safety of [ 13093-04-4 ]

Application In Synthesis of [ 13093-04-4 ]

[ 13093-04-4 ] Synthesis Path-Downstream 1~35

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