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Chemical Structure| 835633-83-5 Chemical Structure| 835633-83-5

Structure of 835633-83-5

Chemical Structure| 835633-83-5

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Product Details of [ 835633-83-5 ]

CAS No. :835633-83-5
Formula : C11H5Cl4N3O
M.W : 336.99
SMILES Code : O=C(C1=CN=C(Cl)N=C1Cl)NC2=C(Cl)C=CC=C2Cl
MDL No. :MFCD26400049

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Application In Synthesis of [ 835633-83-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 835633-83-5 ]

[ 835633-83-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 608-31-1 ]
  • [ 2972-52-3 ]
  • [ 835633-83-5 ]
YieldReaction ConditionsOperation in experiment
With Amberlyst A-21 ion exchange resin; In ethyl acetate; at 60℃; Amberlyst A-21 ion exchange resin (2.14 g) was added to a solution of 2,4- dichloropyrimidine-5-carbonyl chloride (21.4 g, 101.2 mmol) in ethyl acetate (200 mL). The mixture was heated at 60 C. A solution of 2, 6-dichloro aniline (19.68 g, 121. 5 mmol) in ethyl acetate (200 mL) was added dropwise and the reaction mixture was heated at 60 C overnight. The mixture was quenched with water and the organic layer extracted with ethyl acetate (3 x 100 mL), washed with 1 N HC1 (30 mL), 1 M NAOH (30 mL) and brine (30 mL). The organic layer was then dried on sodium sulfate, filtered and concentrated in vacuo. The crude product was washed with dichloromethane (2 x 30 mL) to afford 2, 4-dichloro-5-N- [2, 6- DICHLOROPHENYL] PYRIMIDINE as a pale yellow solid NMR (400 MHz, CDC13) : 10. 88 (1H, s), 9.01 (1H, s), 7.63 (2H, d, J 8.1 Hz), 7.44 (1H, t, J 8. 1 Hz); 13C NMR (400 MHZ, CDC13): 128. 5,128. 7, 130. 0, 131.32, 133.5, 158. 8,159. 5,159. 9, 160. 3; MS : 336 [M+H+]
 

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