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Chemical Structure| 835878-81-4 Chemical Structure| 835878-81-4

Structure of 835878-81-4

Chemical Structure| 835878-81-4

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Product Details of [ 835878-81-4 ]

CAS No. :835878-81-4
Formula : C10H9F3O2
M.W : 218.17
SMILES Code : O=C(OCC)CC1=C(F)C=C(F)C=C1F
MDL No. :MFCD11555118

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Application In Synthesis of [ 835878-81-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 835878-81-4 ]

[ 835878-81-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 835878-81-4 ]
  • [ 65195-35-9 ]
  • 6-(2,4,6-trifluorophenyl)pyrido[2,3-d]pyrimidine-5,7-diol [ No CAS ]
  • 2
  • [ 835878-81-4 ]
  • [ 6557-86-4 ]
  • [ 847983-15-7 ]
YieldReaction ConditionsOperation in experiment
A solution of ethyl trifluorophenylacetate (436 mg, 2.0 mmol) in 3 mL of tetrahydrofuran is cooled to -78 C., and lithium diisopropylamide (2.0 M in heptane/tetrahydrofuran/ethylbenzene, 1.0 mL, 2.0 mmol) is added dropwise with stirring. The mixture is stirred at -78 C. for 1 h, and cycloheptanecarboxylic acid chloride (321 mg, 2.0 mmol) is added dropwise. The mixture is warmed to room temperature and acidified with 2 mL of 1.0 N hydrochloric acid. The product is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride, dried over magnesium sulfate, and concentrated. The residue is chromatographed over silica gel, eluting with a gradient of hexanes to 10% ethyl acetate in hexanes. Concentration provides ethyl 3-cycloheptyl-3-oxo-2-(2,4,6-trifluorophenyl)propanoate as a colorless oil (410 mg). MS: m/z 341.2 (M-H).
 

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