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Chemical Structure| 836-42-0 Chemical Structure| 836-42-0

Structure of 4-(Benzyloxy)benzyl chloride
CAS No.: 836-42-0

Chemical Structure| 836-42-0

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Product Details of [ 836-42-0 ]

CAS No. :836-42-0
Formula : C14H13ClO
M.W : 232.71
SMILES Code : ClCC1=CC=C(OCC2=CC=CC=C2)C=C1
MDL No. :MFCD00000916
InChI Key :UYQPSKUPEXAQRJ-UHFFFAOYSA-N
Pubchem ID :70042

Safety of [ 836-42-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 836-42-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 836-42-0 ]

[ 836-42-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 836-42-0 ]
  • 4-(4-(benzyloxy)benzyl)morpholin-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% To a solution of <strong>[109-11-5]morpholin-3-one</strong> (261 mg, 2.58 mmol) in DMF (10 mL) at 0 C, NaH (172 mg, 4.30 mmol, 60% purity) was added and stirred for 0.5 h. The mixture was warmed to room temperature and 1 -(benzyl oxy)-4-(chloromethyl)benzene (500 mg, 2.15 mmol) added. The mixture was stirred at room temperature for 1.5 h. The reaction mixture was carefully poured into water (30 mL), and then extracted with EtOAc (3 x40 mL). The combined organic layers were washed with brine (2 x30 mL), dried over Na2S04, filtered, concentrated, and then purified by column chromatography (Si02, Petroleum ether/Ethyl acetate=l0/l to 1/1) to give 4-(4- (benzyloxy)benzyl)<strong>[109-11-5]morpholin-3-one</strong> (550 mg, 86%) as a white solid. 1H NMR (400 MHz, DMSO- d6 ): d 7.45-7.43 (m, 2H), 7.40-7.37 (m, 2H), 7.34-7.32 (m, 1H), 7.19 (d, 2H), 6.98 (d, 2H), 5.08 (s, 2H), 4.46 (s, 2H), 4.08 (s, 2H), 3.79-3.76 (m, 2H), 3.22-3.19 (m, 2H); LCMS: 297.9 [M+H]+.
 

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