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Chemical Structure| 844648-16-4 Chemical Structure| 844648-16-4

Structure of 844648-16-4

Chemical Structure| 844648-16-4

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Product Details of [ 844648-16-4 ]

CAS No. :844648-16-4
Formula : C9H7F2NO
M.W : 183.16
SMILES Code : N#CCCOC1=CC(F)=CC(F)=C1
MDL No. :MFCD17216271

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Application In Synthesis of [ 844648-16-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 844648-16-4 ]

[ 844648-16-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 844648-16-4 ]
  • [ 844648-22-2 ]
YieldReaction ConditionsOperation in experiment
80% at 10 - 50℃; Large scale 30 kg of concentrated sulfuric acid was added to reactor A.11 kg of 3- (3,5-difluorophenoxy) propanenitrile was added at 10 to 20 ° C,The mixture was heated to 50 DEG C and stirred. When the reaction was completed, it was cooled to room temperature.Reactor B was charged with 100 L of purified water and cooled to 0 .Reactant A was charged to Reactor B.110 L of dichloromethane was added, and 5percentThe pH was adjusted to 7 using an aqueous solution of sodium hydroxide.After stirring, the organic layer was separated.After concentrating under reduced pressure, 55 L of heptane was added, stirred, and filtered. Vacuum drying at 40 ° C yielded 5,7-difluorochroman-4-one (9 kg, 80percent).
References: [1] Patent: KR2018/11830, 2018, A, . Location in patent: Paragraph 0057; 0082; 0083.
[2] Patent: WO2008/151927, 2008, A2, .
 

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