Home Cart Sign in  
Chemical Structure| 845781-23-9 Chemical Structure| 845781-23-9

Structure of 845781-23-9

Chemical Structure| 845781-23-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 845781-23-9 ]

CAS No. :845781-23-9
Formula : C14H10ClFO
M.W : 248.68
SMILES Code : O=C(C1=CC=C(Cl)C(F)=C1)CC2=CC=CC=C2
MDL No. :MFCD06201639

Safety of [ 845781-23-9 ]

Application In Synthesis of [ 845781-23-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 845781-23-9 ]

[ 845781-23-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 845781-23-9 ]
  • [ 57-13-6 ]
  • [ 1283117-52-1 ]
YieldReaction ConditionsOperation in experiment
9.3% With hydrogenchloride; In ethanol; water; for 48.0h;Reflux; [00188] To a solution of l-(4-chloro-3-fluorophenyl)-2-phenylethanone (Intermediate16) (100 mg, 0.40 mmol), <strong>[178686-24-3]3-ethoxy-4-hydroxy-5-nitrobenzaldehyde</strong> (79.5 mg, 0.40 mmol), and urea (73.2 mg, 1.20 mmol) in 5 mL of ethanol was added 0.2 mL of concentrated HCl solution, and the mixture was refluxed for 2 days. After the solvent was removed under reduced pressure, the residue was purified by reverse-phase preparatory HPLC (26-53% acetonitrile + 0.1% trifluoroacetic acid in water + 0.1% trifluoroacetic acid, over 15 min.) to give Compound 43 (18 mg, yield 9.3%). 1H NMR (DMSO-d6 300 MHz) delta 10.29 (s, 1H), 8.83 (s, 1H), 7.57 (s, 1H), 7.44 (m, 2H), 7.28 (d, J = 9.9 Hz, 1H), 7.13-6.86 (m, 4H), 5.26 (s, 1H), 4.04 (m, 2H), 1.32 (t, J = 6.3 Hz, 3H); MS (ESI): m/z 483.9 [M+l]+.
 

Historical Records

Technical Information

Categories