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Chemical Structure| 84689-36-1 Chemical Structure| 84689-36-1

Structure of 84689-36-1

Chemical Structure| 84689-36-1

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Product Details of [ 84689-36-1 ]

CAS No. :84689-36-1
Formula : C11H11NO
M.W : 173.21
SMILES Code : CC1=NC2=CC=CC=C2C=C1OC
MDL No. :MFCD13193350

Safety of [ 84689-36-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 84689-36-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 84689-36-1 ]

[ 84689-36-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 84689-36-1 ]
  • [ 5780-66-5 ]
  • C16H13N3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With toluene-4-sulfonamide; In toluene; at 120℃; for 12h;Inert atmosphere; A solution of 3-methoxy-2-methylquinoline (100 mg, 0.57 mmol), p-toluenesulfonamide (98.85 mg, 0.57 mmol) and pyrazine-2-carbaldehyde (61.5 mg, 0.57 mmol) in toluene (0.5 mL) was refluxed at 120° C. for 12 h in a reaction tube under nitrogen. After the mixture was cooled to room temperature, the solvent was removed under reduced pressure. Then the concentrate was purified by column chromatography with EtOAc/DCM (1:2, v/v) on silica gel, affording TZ-23-22 (133 mg, 89percent). 1H-NMR (400 MHz, CDCl3): delta 8.67 (d, J=1.2 Hz, 1H), 8.59-8.46 (s, 1H), 8.36 (d, J=2.4 Hz, 1H), 8.28 (d, J=15.7 Hz, 1H), 8.03-7.90 (m, 2H), 7.68-7.57 (m, 1H), 7.54-7.36 (m, 2H), 7.29 (s, 1H), 3.89 (s, 3H). 13C NMR (101 MHz, CDCl3) delta 151.80, 150.96, 147.23, 144.83, 144.54, 143.35, 142.97, 129.94, 129.20, 129.16, 128.33, 127.04, 126.97, 126.26, 112.25, 55.43.
 

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