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Chemical Structure| 848485-43-8 Chemical Structure| 848485-43-8

Structure of 848485-43-8

Chemical Structure| 848485-43-8

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Product Details of [ 848485-43-8 ]

CAS No. :848485-43-8
Formula : C10H7F3INO3
M.W : 373.07
SMILES Code : O=C(OC)C1=CC=C(NC(C(F)(F)F)=O)C(I)=C1
MDL No. :MFCD11501882

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Application In Synthesis of [ 848485-43-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848485-43-8 ]

[ 848485-43-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 848485-43-8 ]
  • [ 23152-99-0 ]
  • C19H19NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In N,N-dimethyl-formamide; at 80℃; for 20h;Sealed tube; A mixture of methyl 3-iodo-4-[(trifluoroacetyl)amino]benzoate from above (25 mg, 0.067 mmol), l-ethynyl-4-(l-methylethyl)benzene (14.5 mg, 0.101 mmol), copper(I)-iodide (2.6 mg, 0.013 mmol), Pd(PPh3)2Cl2 (4.7 mg, 0.007 mmol) and diethylamine (20 mu, 0.101 mmol) in DMF (0.5 ml) was heated in a sealed tube at 80 C for 20 h. The mixture was poured into water and DCM was added. The water phase was extracted with DCM. The combined organic layers were evaporated and the crude product was purified by flash column chromatography using 20% EtOAc in n-heptane as eluent Yield: 13 mg (66%>); white solid. MS (ESI+) m/z 294 [M+H]+. HPLC purity: 89%.
 

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