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Chemical Structure| 848498-79-3 Chemical Structure| 848498-79-3

Structure of 848498-79-3

Chemical Structure| 848498-79-3

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Product Details of [ 848498-79-3 ]

CAS No. :848498-79-3
Formula : C6H6BrNO2
M.W : 204.02
SMILES Code : O=C(C1=CC(Br)=C(C)N1)O

Safety of [ 848498-79-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 848498-79-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848498-79-3 ]

[ 848498-79-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5754-35-8 ]
  • [ 848498-79-3 ]
  • 4-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1H-pyrrole-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% A mixture of 4-bromo-5-methyl-1H-pyrrole-2-carboxylic acid1 (2.36g, 11.57mmol)and HATU (4.84 g, 12.72 mmol) was dissolved in anhydrous N,N-Dimethylformamide (30mL) and treated with N,N-Diisopropylethylamine (2.2 mL, 12.72 mmol) and after 1 minute<strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethanamine</strong> (1.49 g, 12.72 mmol) was added. After stirring for 18h atambient temperature, the mixture was partitioned between 2M HCl(aq) and CHCl3. Theorganic layer was separated, washed with sat. NaHCO3(aq) solution and passed through ahydrophobic frit. The resulting filtrate was concentrated and purified by silicachromatography, eluting with 0 to 40% EtOAc/ cyclohexane mixtures to give 4-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1H-pyrrole-2-carboxamide as a cream solid (2.22g,63%).
 

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