[ CAS No. 5754-35-8 ]

Name: 5754-35-8|2-(1,3-Dioxolan-2-yl)ethanamine|98%
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SKU: A581331
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Quality Control of [ 5754-35-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 5754-35-8 ]

Product Details of [ 5754-35-8 ]

CAS No. :	5754-35-8	MDL No. :	MFCD00142756
Formula :	C₅H₁₁NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	117.15	Pubchem ID :	-
Synonyms :

Safety of [ 5754-35-8 ]

Signal Word:	Danger	Class:	3,8
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	2733
Hazard Statements:	H226-H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 5754-35-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 5754-35-8 ]

[ 5754-35-8 ] Synthesis Path-Downstream 1~68

1
[ 5754-35-8 ]
[ 74-88-4 ]
(2-[1,3]dioxolan-2-yl-ethyl)-trimethyl-ammonium; iodide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 115,116

2
[ 64-17-5 ]
[ 185563-61-5 ]
[ 5754-35-8 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 115,116

3
[ 5754-35-8 ]
[ 35302-72-8 ]
[ 154468-39-0 ]

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 456 - 464
[2]Tetrahedron Letters,1994,vol. 35,p. 351 - 354

4
[ 5754-35-8 ]
[ 50371-52-3 ]
[ 154468-43-6 ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile;	4,5-Dibromo-N-[2-(1,3-dioxolan-2-yl)ethyl]pyrrole-2-carboxamide (11). A solution of <strong>[5754-35-8]2-(2-aminoethyl)-1,3-dioxolane</strong> (2.4 g, 20.6 mmol) and 4,5-dibromopyrrol-2-yl trichloromethyl ketone (7.6 g, 20.5 mmol) in 30 mL of acetonitrile was stirred at room temperature for 16 h. The reaction mixture was filtered and the precipitate 11 (6.8 g, 90%) was collected as a colorless solid: mp 155-157 C.; 1H NMR (CDCl3) d 1.99 (dt, 2H, J=6.0, 4.2), 3.61 (dt, 2H, J=6.0, 5.6), 3.92 (m, 2H), 4.05 (m, 2H), 5.00 (t, 1H, J=4.2), 6.51 (d, 1H, J=2.8), 6.66 (bs, 1H), 10.57 (bs, 1H); 13C NMR (CD3COCD3) d 34.3 (e), 35.5 (e), 65.4*2 (e), 99.4 (e), 103.4 (o), 105.4 (e), 113.0 (o), 129.1 (e), 160.0 (e); IR (nujol) 3358, 1646, 1569, 1412, 1372 cm-1; UV (CH3OH) 1max 275, 233, 214 (sh) nm; MS m/z (relative intensity) 371 (M++5, 50), 369 (M++3, 100), 367 (M++1, 50), 289 (13), 118 (25), 101 (50), 73 (30); Anal. Calcd for C8H10N2O2Br2: C, 32.63; H, 3.29; N, 7.61; Found: C, 32.77; H, 3.17; N, 7.51.

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 456 - 464
[2]Organic Letters,2003,vol. 5,p. 2735 - 2738
[3]Tetrahedron Letters,1999,vol. 40,p. 5519 - 5522
[4]Tetrahedron Letters,1994,vol. 35,p. 351 - 354
[5]Patent: US6197954,2001,B1

5
[ 5754-35-8 ]
[ 2969-81-5 ]
[ 111752-09-1 ]

Reference： [1]Synthetic Communications,1987,vol. 17,p. 377 - 384

6
[ 5754-35-8 ]
[ 69367-52-8 ]
[ 104568-95-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

7
[ 5754-35-8 ]
[ 14527-26-5 ]
[ 82892-14-6 ]

Reference： [1]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045

8
[ 5754-35-8 ]
[ 141-97-9 ]
(E)-3-(2-[1,3]Dioxolan-2-yl-ethylamino)-but-2-enoic acid ethyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

9
[ 5754-35-8 ]
ethyl α-bromo-4-fluorobenzeneacetate [ No CAS ]
ethyl α-<<2-(1,3-dioxolan-2-yl)ethyl>amino>-4-fluorobenzeneacetate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

10
[ 5754-35-8 ]
[ 7152-15-0 ]
[ 135833-73-7 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

11
[ 5754-35-8 ]
[ 4949-44-4 ]
[ 135833-70-4 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

12
[ 82891-99-4 ]
[ 5754-35-8 ]

Reference： [1]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045

13
[ 111752-08-0 ]
[ 5754-35-8 ]

Reference： [1]Synthetic Communications,1989,vol. 19,p. 3289 - 3294
[2]Synthetic Communications,1987,vol. 17,p. 377 - 384
[3]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836
[4]Arkivoc,2019,vol. 2019,p. 178 - 195

14
[ 5754-35-8 ]
[ 98-59-9 ]
[ 960209-12-5 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 10485 - 10494
[2]Organic Letters,2007,vol. 9,p. 5063 - 5066
[3]Tetrahedron,2002,vol. 58,p. 4459 - 4479

15
[ 5754-35-8 ]
[ 1477-50-5 ]
N-[2-(1,3-dioxolan-2-yl)ethyl]-1H-indole-2-carboxamide [ No CAS ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 10181 - 10188

16
[ 5754-35-8 ]
[ 167631-58-5 ]
N-[2-(1,3-dioxolan-2-yl)ethyl]-3-iodo-1H-indole-2-carboxamide [ No CAS ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 10181 - 10188

17
[ 5754-35-8 ]
[ 30562-34-6 ]
17-[2-(dioxolan-2-yl)ethyl]amino-17-demethoxygeldanamycin [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 5317 - 5329

18
[ 5754-35-8 ]
[ 54644-12-1 ]
5-ethoxy-2-phenyl-oxazole-4-carboxylic acid (2-[1,3]dioxolan-2-yl-ethyl)-amide [ No CAS ]

Reference： [1]Tetrahedron,2006,vol. 62,p. 4698 - 4704

19
[ 5754-35-8 ]
[ 463-71-8 ]
[ 1246860-85-4 ]

Yield	Reaction Conditions	Operation in experiment
100%	With calcium carbonate; In dichloromethane; water; at 20℃; for 18.0833h;	CaCO3 (1.36g, 13.66mmol) was added to a vigorously stirred solution of 2-[1 ,3]dioxolan- 2-yl-ethylamine (1.Og, 8.54mmol) in DCM (20ml) and water (10ml). Thiophosgene (0.85ml, 11.10mmol) was added dropwise over 5 min and the resultant biphasic mixture was vigorously stirred at RT for 18h. The reaction mixture was diluted with water (40ml) and the organic phase was separated. The aqueous layer was extracted with DCM (2 x 40ml) and the combined organic layers were washed with water (50ml) followed by brine (50ml), dried (Na2SO4) and concentrated in vacuo to give a yellow oil (1.36g, 100%). This material was used in the next step without further purification.

Reference： [1]Patent: WO2007/129048,2007,A1 .Location in patent: Page/Page column 35

20
[ 5754-35-8 ]
[ 474759-03-0 ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 4459 - 4479

21
[ 18742-02-4 ]
[ 5754-35-8 ]

Reference： [1]Synthetic Communications,1987,vol. 17,p. 377 - 384
[2]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045
[3]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836
[4]Arkivoc,2019,vol. 2019,p. 178 - 195

22
[ 5754-35-8 ]
[ 135833-79-3 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

23
[ 5754-35-8 ]
[ 110862-44-7 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

24
[ 5754-35-8 ]
[ 135833-80-6 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

25
[ 5754-35-8 ]
[ 104568-93-6 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

26
[ 5754-35-8 ]
[ 110862-43-6 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

27
[ 5754-35-8 ]
[ 104568-94-7 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

28
[ 5754-35-8 ]
[ 135833-89-5 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

29
[ 5754-35-8 ]
[ 135833-74-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

30
[ 5754-35-8 ]
[ 135833-71-5 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

31
[ 5754-35-8 ]
[ 104568-72-1 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

32
[ 5754-35-8 ]
1-(2-[1,3]Dioxolan-2-yl-ethyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366
[2]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

33
[ 5754-35-8 ]
[ 135833-76-0 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

34
[ 5754-35-8 ]
[ 135833-90-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

35
[ 5754-35-8 ]
[ 135833-91-9 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

36
[ 5754-35-8 ]
[ 110862-45-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

37
[ 5754-35-8 ]
[ 135833-78-2 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366

38
[ 5754-35-8 ]
[ 32315-10-9 ]
[ 134-20-3 ]
2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With triethylamine; In dichloromethane; ethyl acetate;	Example 4 2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic Acid Methyl Ester Methylanthranilate (1.18 g, 7.79 mmol) and triethylamine (2.5 mL, 17.7 mmol) in methylene chloride (10 mL) were cooled in an ice bath. Triphosgene (0.69 g, 2.34 mmol) in methylene chloride (10 ml) was added dropwise over 10 minutes. and the resulting mixture was stirred for 1 hour at 0 C. to form the isocyanate intermediate. 2-(2-Aminoethyl)-1,3-dioxolane(2.00 g, 17.1 mmol) in methylene chloride (10 ml) was added dropwise at 0 C. over 10 minutes., then the mixture was warmed to ambient temperature and stirred for 15 hours. Concentration yielded a yellow solid which was taken up in ethyl acetate and sat. sodium bicarbonate solution; the layers were separated. The organic layer was washed with brine, dried over magnesium sulfate. Concentration yielded 2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic acid methyl ester (1.26 g, 60%) as a white solid. 1H NMR CDCl3 delta 10.26 (brd s, 1H), 8.51-8.44 (m, 1H), 7.95 (dd, J=2, 8 Hz, 1H), 7.49-7.44 (m, 1H), 6.95-6.91 (m, 1H), 5.35-5.10(brd s, 1H), 4.95 (t, J=4 Hz, 1H), 4.01-3.98 (m, 2H), 3.88 (S, 3H), 3.87-3.82 (m, 2H), 3.44 (t, J=6 Hz, 2H), 1.96-1.92 (m, 2H).

Reference： [1]Patent: US2002/52355,2002,A1
[2]Patent: EP1178048,2002,A1 .Location in patent: Example 4

39
[ 5754-35-8 ]
[ 128071-75-0 ]
[ 332881-75-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; sodium tris(acetoxy)borohydride; In acetic acid; 1,2-dichloro-ethane;	Step A N-((2-Bromo(3-pyridyl))methyl)-<strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethylamine</strong> To a solution of 2-bromopyridine-3-carbaldehyde (3.53 g, 19.0 mmol, 1.0 eq) (Melnyk et al., Synthetic Commun. 23(19):2727-2730, 1993) in 1,2-dichloroethane (50 mL) was added <strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethylamine</strong> (TCI-GR, 2.67 g, 22.8 mmol, 1.2 eq), sodium triacetoxyborohydride (Aldrich, 1.61 g, 76 mmol, 4.0 eq) and glacial acetic acid (1.14 g, 19 mmol, 1.0 eq). The reaction mixture was stirred under nitrogen at room temperature for 2 h. The reaction was quenched with 1.0 N aqueous NaOH to about pH 8 and the solution was extracted with EtOAc (200 mL*3). The organic extracts were washed with saturated NaCl, dried with MgSO4, filtered and concentrated. Flash column chromatography (silica gel, 0-10% EtOAc-Hexane) afforded the title compound as a colorless oil. MS m/z 377 (Br=79, M+H), 379 (Br=81, M+H).

Reference： [1]Patent: US6514964,2003,B1

40
[ 18742-02-4 ]
NH₂NH_2.H₂O [ No CAS ]
Bu₄N+HSO₄- [ No CAS ]
[ 1074-82-4 ]
[ 5754-35-8 ]

Yield	Reaction Conditions	Operation in experiment
73%	In ethanol; toluene;	A) 2-(2-Aminoethyl)-1,3-dioxolane A suspension of 50 g of 2-(2-bromoethyl)-1,3-dioxolane (product known in literature, CAS RN = 5754-35-8) (0.27 mL, 32.5 mol), 62.5 g of potassium phthalimide (0.34 mol), 9.16 g of Bu4N+HSO4- (0.027 mol) in 150 ml of toluene was heated to 100C and under N2 stream for 3 h. After cooling to room temperature, the mixture was filtered and evaporated to dryness. By crystallization of the residue from abs. EtOH the phthalimido derivative was obtained. A solution of 58.5 g of NH2NH2.H2O (1.17 ml; 56.8 mol), 64.36 g of phthalimido derivative (0.26 mol) in 2 l of abs. EtOH was heated to reflux under N2 stream for 2.5 h. After cooling to 0C, the precipitated phthalhydrazide was filtered through a sintered funnel. By evaporation of the filtrate to dryness, 23.26 g of the desired product (0.198 mol) were obtained. Yield: 73% The 1H-NMR, 13C-NMR, IR and MS spectra are consistent with the indicated structure.

Reference： [1]Patent: EP760683,2000,B1

41
[ 5754-35-8 ]
[ 124628-32-6 ]
[ 170728-43-5 ]

Yield	Reaction Conditions	Operation in experiment
66%	With triethylamine; In chloroform;	A) 2-Chloro-N-[2-(1,3-dioxolan-2-yl)ethyl]-3-phenylmethoxypropanamide A solution of 69.63 g of 2-chloro-3-(phenylmethoxy)propanoyl chloride (prepared according to the procedure described in Inorg. Chem., 31. 2422, 1992) (0.299 mol) in 90 ml of CHCl3 was added to a solution of 35.49 g of <strong>[5754-35-8]2-(2-aminoethyl)-1,3-dioxolane</strong> (prepared according to the procedure described in EXAMPLE 4) (0.303 mol) and to 60.3 g of triethylamine (83 ml; 0.596 mol) in 100 ml of CHCl3 under inert atmosphere, keeping the temperature at 0-5C. The reaction mixture was stirred for 5 h at 25C, then was washed with H2O. The organic phase was dried and evaporated to dryness, the residue was purified by flash chromatography. 61.68 g of the desired product (0.197 mol) were obtained. Yield: 66% TLC: Carrier: silica gel plates 60 F254 Merck Eluent: AcOEt: n-hexane = 1:1 (v/v)

Reference： [1]Patent: EP760683,2000,B1

42
[ 5754-35-8 ]
[ 935440-23-6 ]
[ 935440-34-9 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In tert-butyl methyl ether; at 20℃; for 1h;	To a solution of 660 mg of 2-aminomethyl-l, 3-dioxolan in 20 mL of tert-butylmethyl ether were added 0.33 mL of triethylamine and then 614 mg of N- [2-fluoro-4- (trifluoromethylthio) phenyl] -N-methylcarbamoyl chloride, and stirred at room temperature for an hour. The reaction solution was washed sequentially with water and a saturated saline solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by medium pressure preparative high performance liquid chromatography (hexane : ethyl acetate = 50 : 50) to give 600 mg of 3- [( 1, 3-dioxolan-2-yl) methyl] -1- [2-fluoro-4- (trifluoromethylthio) phenyl] -1-methylurea .3- (1, 3-Dioxolan-2-yl)methyl] -1- [2-fluoro-4- (trifluoromethylthio) phenyl] -1-methylurea1H-NMR (CDCl3) ?(ppm) : 3.25 (3H, s) , 3.45 (2H, dd, J = 5.9,3.7 Hz) , 3.82-3.92 (4H, m) , 4.54 (IH, br) , 4.93 (IH, t, J = 3.7 Hz) , 7.38 (IH, t, J = 8.2 Hz) , 7.45-7.53 (2H, m) .

Reference： [1]Patent: WO2007/46513,2007,A2 .Location in patent: Page/Page column 210

43
[ 5754-35-8 ]
[ 905971-91-7 ]
[ 905970-21-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 767 - 771

44
[ 5754-35-8 ]
[ 1024500-44-4 ]
[ 1024500-49-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	In 1-methyl-pyrrolidin-2-one; at 50℃; for 1.5h;	Stage 1 - 4-(2-Chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-[2-(1 ,3-dioxolan-2- yl)ethyl]amino}pyrido[2,3-c/]pyrimidin-7(8/-/)-oneA solution of 4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)- pyrido[2,3-cf]pyrimidin-7(8H)-one (Intermediate F) (50 mg, 0.11 mmol) and 2- [1 ,3]dioxolan-2-yl-ethylamine (63 mg, 0.54 mmol) in NMP (5 ml.) was heated at 50 0C for 1.5 hours. Water (20 ml_) was added followed by EtOAc (20 ml_). The layers were separated and the organic phase washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography (0-50 % EtOAc in heptane) to afford the title compound (46 mg, 85 % yield). m/z 503 [M+H]+.

Reference： [1]Patent: WO2008/53158,2008,A1 .Location in patent: Page/Page column 64

45
[ 5754-35-8 ]
[ 50-00-0 ]
[ 646-01-5 ]
[ 1185859-77-1 ]
C₂₆H₃₇N₃O₆S [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898

46
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 453-71-4 ]
C₂₉H₃₃FN₄O₈ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898

47
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 1759-53-1 ]
C₂₆H₃₅N₃O₆ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898

48
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 98-89-5 ]
C₂₉H₄₁N₃O₆ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898

49
[ 5754-35-8 ]
3-anilino-5-{2-[(tetrahydro-2H-pyran-4-ylcarbonyl)amino]pyridin-4-yl}benzoic acid [ No CAS ]
N-{4-[3-anilino-5-([2-(1,3-dioxolan-2-yl)ethyl]amino}carbonyl)phenyl]pyridin-2-yl}tetrahydro-2H-pyran-4-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%		3-anilino-5-{2-[(tetrahydro-2H-pyran-4-ylcarbonyl)amino]pyridin-4-yl}benzoic acid (42 mg, 0.10 mmol) AND N [ (DIMETHYLAMINO) (3H- [1, 2,3] triazolo [4, 5-B] pyridin-3- yloxy) METHYLENE]-N-METHYLMETHANAMINIUM hexafluorophosphate (58 mg, 0.15 mmol) were dissolved in 3 ML of DMF. Diisopropylethylamine (35 muL, 0.20 mmol) was added dropwise and the solution stirred for lh at room temperature under nitrogen atmosphere. Then a solution of [2- (1, 3-dioxolan-2-yl) ethyl] amine (11.7 mg, 0.10 mmol) in DMF (0.5 mL) was slowly added and the mixture stirred at 20C for 15h. The solution was poured on a saturated aqueous solution OF NAHC03 (15 mL) and extracted with ethyl acetate. After concentration of the solvent under vacuum, the crude material was purified by HPLC. Yield: 52% (27 mg). 1H NMR (400 MHz, CDC13) : 8 8.79 (s, 1H), 8. 50 (s, 1H), 8. 24 (d, J=5.5 Hz, 1H), 7.56 (t, J= 1.7 Hz, 1H), 7.49 (t, J= 1.3 Hz, 1H), 7.37 (t, J= 1./ Hz, 1H), 7.28 (m, 3H), 7.13 (m, 2H), 7.07 (m, 1H), 7.01 (m, 1H), 6.16 (s, 1H), 5.00 (t, J = 4.2 Hz, 1H), 4.02 (m, 4H), 3.87 (m, 2H), 3.63 (m, 2H), 3. 48 (td, J= 11.4/2. 6 Hz, 2H), 2.57 (m, 1H), 2.02 (m, 2H), 1.93-1. 85 (m, 4H). 13C NMR (101 MHz, CDC13) : 8 173.31 (s, 1 C), 166.71 (s, 1 C), 152.05 (s, 1 C), 150.59 (s, 1 C), 147.62 (s, 1 C), 144.63 (s, 1 C), 141.92 (s, 1 C), 139.56 (s, 1 C), 136.87 (s, 1 C), 129.51 (s, 2 C), 122.11 (s, 1 C), 118.93 (s, 2 C), 118.07 (s, 1 C), 117.98 (s, 1 C), 117.18 (s, 1 C), 115.65 (s, 1 C), 111.97 (s, 1 C), 103.91 (s, 1 C), 67.03 (s, 2 C), 64.96 (s, 2 C), 42.97 (s, 1 C), 35.29 (s, 1 C), 32.31 (s, 1 C), 28.95 (s, 2 C). MS (ES) M/Z (M+1) : 517.

Reference： [1]Patent: WO2005/3123,2005,A1 .Location in patent: Page 35

50
[ 5754-35-8 ]
[ 4440-33-9 ]
[ 1215194-50-5 ]

Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 3244 - 3245

51
[ 5754-35-8 ]
[ 13049-86-0 ]
C₁₆H₂₇NO₈ [ No CAS ]
C₁₆H₂₇NO₈ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2011,vol. 76,p. 6432 - 6437

52
[ 5754-35-8 ]
[ 33821-61-3 ]
[ 1403498-94-1 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8948 - 8952,5

53
[ 5754-35-8 ]
N-(3-(1H-imidazol-1-yl)propyl)-2-bromo-1,3-thiazole-5-carboxamide [ No CAS ]
C₁₅H₂₁N₅O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile; at 120℃;	General procedure: Example 6A (2 g, 6.35 mmol) and (4-fluorophenyl)methanamine (0.794 g, 6.35 mmol) in acetonitrile (10 ml) were stirred at 120 C overnight. The reaction mixture was cooled, concentrated, taken into ethyl acetate and washed with saturated aqueous NaHC03 and brine. The combined aqueous layers were extracted twice with ethyl acetate. The combined organic extracts were dried (MgS04) and filtered. The filtrate was concentrated until solid material precipitated. The mixture was filtered to provide the title compound.

Reference： [1]Patent: WO2013/170118,2013,A1 .Location in patent: Page/Page column 129

54
[ 5754-35-8 ]
[ 5430-45-5 ]
[ 1538625-40-9 ]

Reference： [1]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627

55
[ 5754-35-8 ]
[ 2398-37-0 ]
[ 1538625-25-0 ]

Reference： [1]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627

56
[ 5754-35-8 ]
[ 2845-89-8 ]
[ 1538625-25-0 ]

Reference： [1]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627
[2]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627

57
[ 5754-35-8 ]
[ 873-76-7 ]
C₁₂H₁₇NO₃ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 11942 - 11945

58
[ 5754-35-8 ]
[ 24388-23-6 ]
N-(2-(1,3-dioxolan-2-yl)ethyl)aniline [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 3942 - 3950
[2]Journal of the American Chemical Society,2017,vol. 139,p. 4769 - 4779

59
[ 5754-35-8 ]
[ 32315-10-9 ]
3-[4-aminophenyl]-3-trifluoromethyl-3H-diazirine [ No CAS ]
1-(2-(1,3-dioxolan-2-yl)ethyl)-3-(4-(3-trifluoromethyl)-3H-diazirin-3-yl)phenylurea [ No CAS ]

Reference： [1]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836

60
[ 5754-35-8 ]
[ 32315-10-9 ]
[ 769-92-6 ]
1-(2-(1,3-dioxolan-2-yl)ethyl)-3-(4-(tert-butyl)phenyl)urea [ No CAS ]

Reference： [1]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836

61
[ 5754-35-8 ]
[ 158478-77-4 ]
C₁₉H₃₄N₄O₇ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2016,vol. 55,p. 7492 - 7495
Angew. Chem.,2016,vol. 128,p. 7618 - 7621,4

62
[ 5754-35-8 ]
[ 848498-79-3 ]
4-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1H-pyrrole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%		A mixture of 4-bromo-5-methyl-1H-pyrrole-2-carboxylic acid1 (2.36g, 11.57mmol)and HATU (4.84 g, 12.72 mmol) was dissolved in anhydrous N,N-Dimethylformamide (30mL) and treated with N,N-Diisopropylethylamine (2.2 mL, 12.72 mmol) and after 1 minute<strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethanamine</strong> (1.49 g, 12.72 mmol) was added. After stirring for 18h atambient temperature, the mixture was partitioned between 2M HCl(aq) and CHCl3. Theorganic layer was separated, washed with sat. NaHCO3(aq) solution and passed through ahydrophobic frit. The resulting filtrate was concentrated and purified by silicachromatography, eluting with 0 to 40% EtOAc/ cyclohexane mixtures to give 4-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1H-pyrrole-2-carboxamide as a cream solid (2.22g,63%).

Reference： [1]Molecular Pharmacology,2016,vol. 90,p. 65 - 79

63
[ 5754-35-8 ]
5-bromo-4-methyl-1H-pyrrole-2-carboxylic acid [ No CAS ]
5-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-4-methyl-1H-pyrrole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37.3%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20℃; for 2h;	A mixture of 4-bromo-5-methyl-1H-pyrrole-2-carboxylic acid1 (2.36g, 11.57mmol)and HATU (4.84 g, 12.72 mmol) was dissolved in anhydrous N,N-Dimethylformamide (30mL) and treated with N,N-Diisopropylethylamine (2.2 mL, 12.72 mmol) and after 1 minute<strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethanamine</strong> (1.49 g, 12.72 mmol) was added. After stirring for 18h atambient temperature, the mixture was partitioned between 2M HCl(aq) and CHCl3. Theorganic layer was separated, washed with sat. NaHCO3(aq) solution and passed through ahydrophobic frit. The resulting filtrate was concentrated and purified by silicachromatography, eluting with 0 to 40% EtOAc/ cyclohexane mixtures to give 4-bromo-N-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1H-pyrrole-2-carboxamide as a cream solid (2.22g,63%).

Reference： [1]Molecular Pharmacology,2016,vol. 90,p. 65 - 79

64
[ 5754-35-8 ]
[ 28920-43-6 ]
(9H-fluoren-9-yl)methyl(2-(1,3-dioxolan-2-yl)ethyl)carbamate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 2636 - 2639
Angew. Chem.,2017,vol. 129,p. 2680 - 2683,4

65
[ 5754-35-8 ]
C₃₈H₄₉N₆O₉S₂^(1-) [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 2636 - 2639
Angew. Chem.,2017,vol. 129,p. 2680 - 2683,4

66
[ 5754-35-8 ]
C₄₃H₅₂N₇O₁₃S₂^(1-) [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 2636 - 2639
Angew. Chem.,2017,vol. 129,p. 2680 - 2683,4

67
[ 5754-35-8 ]
(9H-fluoren-9-yl)methyl (3-azido-3-(2-hydroxyethoxy)propyl)carbamate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 2636 - 2639
Angew. Chem.,2017,vol. 129,p. 2680 - 2683,4

68
[ 5754-35-8 ]
2-(3-amino-1-azidopropoxy)ethanol [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 2636 - 2639
Angew. Chem.,2017,vol. 129,p. 2680 - 2683,4

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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
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P370	In case of fire:
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P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H261	In contact with water releases flammable gas
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H300	Fatal if swallowed
H301	Toxic if swallowed
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H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
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H361	Suspected of damaging fertility or the unborn child
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H362	May cause harm to breast-fed children
H370	Causes damage to organs
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H372	Causes damage to organs through prolonged or repeated exposure
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5754-35-8 ]

Quality Control of [ 5754-35-8 ]

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Application In Synthesis of [ 5754-35-8 ]

[ 5754-35-8 ] Synthesis Path-Downstream 1~68

Related Functional Groups of [ 5754-35-8 ]

Amines

Related Parent Nucleus of [ 5754-35-8 ]

Dioxolanes

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[ 5754-35-8 ]

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[ 5754-35-8 ]