5754-35-8|2-(1,3-Dioxolan-2-yl)ethanamine| Ambeed

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Structure of 5754-35-8

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Quality Control of [ 5754-35-8 ] Purity: 98% SDS Specification

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Product Details of [ 5754-35-8 ]

CAS No. :	5754-35-8
Formula :	C₅H₁₁NO₂
M.W :	117.15
SMILES Code :	NCCC1OCCO1
MDL No. :	MFCD00142756

Safety of [ 5754-35-8 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H226-H314
Precautionary Statements:	P280-P305+P351+P338-P310
Class:	3(8)
UN#:	2733
Packing Group:	Ⅲ

Application In Synthesis of [ 5754-35-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 5754-35-8 ]

[ 5754-35-8 ] Synthesis Path-Downstream 1~55

1
[ 5754-35-8 ]
[ 74-88-4 ]
(2-[1,3]dioxolan-2-yl-ethyl)-trimethyl-ammonium; iodide [ No CAS ]

References: [1]Journal of Organic Chemistry,1956,vol. 21,p. 115,116.

2
[ 64-17-5 ]
[ 185563-61-5 ]
[ 5754-35-8 ]

References: [1]Journal of Organic Chemistry,1956,vol. 21,p. 115,116.

3
[ 5754-35-8 ]
[ 35302-72-8 ]
[ 154468-39-0 ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 456 - 464.
[2]Tetrahedron Letters,1994,vol. 35,p. 351 - 354.

4
[ 5754-35-8 ]
[ 50371-52-3 ]
[ 154468-43-6 ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile;	4,5-Dibromo-N-[2-(1,3-dioxolan-2-yl)ethyl]pyrrole-2-carboxamide (11). A solution of <strong>[5754-35-8]2-(2-aminoethyl)-1,3-dioxolane</strong> (2.4 g, 20.6 mmol) and 4,5-dibromopyrrol-2-yl trichloromethyl ketone (7.6 g, 20.5 mmol) in 30 mL of acetonitrile was stirred at room temperature for 16 h. The reaction mixture was filtered and the precipitate 11 (6.8 g, 90%) was collected as a colorless solid: mp 155-157 C.; 1H NMR (CDCl3) d 1.99 (dt, 2H, J=6.0, 4.2), 3.61 (dt, 2H, J=6.0, 5.6), 3.92 (m, 2H), 4.05 (m, 2H), 5.00 (t, 1H, J=4.2), 6.51 (d, 1H, J=2.8), 6.66 (bs, 1H), 10.57 (bs, 1H); 13C NMR (CD3COCD3) d 34.3 (e), 35.5 (e), 65.4*2 (e), 99.4 (e), 103.4 (o), 105.4 (e), 113.0 (o), 129.1 (e), 160.0 (e); IR (nujol) 3358, 1646, 1569, 1412, 1372 cm-1; UV (CH3OH) 1max 275, 233, 214 (sh) nm; MS m/z (relative intensity) 371 (M++5, 50), 369 (M++3, 100), 367 (M++1, 50), 289 (13), 118 (25), 101 (50), 73 (30); Anal. Calcd for C8H10N2O2Br2: C, 32.63; H, 3.29; N, 7.61; Found: C, 32.77; H, 3.17; N, 7.51.

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 456 - 464.
[2]Organic Letters,2003,vol. 5,p. 2735 - 2738.
[3]Tetrahedron Letters,1999,vol. 40,p. 5519 - 5522.
[4]Tetrahedron Letters,1994,vol. 35,p. 351 - 354.
[5]Patent: US6197954,2001,B1 .

5
[ 5754-35-8 ]
[ 2969-81-5 ]
[ 111752-09-1 ]

References: [1]Synthetic Communications,1987,vol. 17,p. 377 - 384.

6
[ 5754-35-8 ]
[ 69367-52-8 ]
[ 104568-95-8 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

7
[ 5754-35-8 ]
[ 14527-26-5 ]
[ 82892-14-6 ]

References: [1]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045.

8
[ 5754-35-8 ]
[ 141-97-9 ]
(E)-3-(2-[1,3]Dioxolan-2-yl-ethylamino)-but-2-enoic acid ethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

9
[ 5754-35-8 ]
ethyl α-bromo-4-fluorobenzeneacetate [ No CAS ]
ethyl α-<<2-(1,3-dioxolan-2-yl)ethyl>amino>-4-fluorobenzeneacetate [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

10
[ 5754-35-8 ]
[ 7152-15-0 ]
[ 135833-73-7 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

11
[ 5754-35-8 ]
[ 4949-44-4 ]
[ 135833-70-4 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

12
[ 82891-99-4 ]
[ 5754-35-8 ]

References: [1]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045.

13
[ 111752-08-0 ]
[ 5754-35-8 ]

References: [1]Synthetic Communications,1989,vol. 19,p. 3289 - 3294.
[2]Synthetic Communications,1987,vol. 17,p. 377 - 384.
[3]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836.
[4]Arkivoc,2019,vol. 2019,p. 178 - 195.

14
[ 5754-35-8 ]
[ 98-59-9 ]
[ 960209-12-5 ]

References: [1]Tetrahedron,2009,vol. 65,p. 10485 - 10494.
[2]Organic Letters,2007,vol. 9,p. 5063 - 5066.
[3]Tetrahedron,2002,vol. 58,p. 4459 - 4479.

15
[ 5754-35-8 ]
[ 1477-50-5 ]
N-[2-(1,3-dioxolan-2-yl)ethyl]-1H-indole-2-carboxamide [ No CAS ]

References: [1]Tetrahedron,2002,vol. 58,p. 10181 - 10188.

16
[ 5754-35-8 ]
[ 167631-58-5 ]
N-[2-(1,3-dioxolan-2-yl)ethyl]-3-iodo-1H-indole-2-carboxamide [ No CAS ]

References: [1]Tetrahedron,2002,vol. 58,p. 10181 - 10188.

17
[ 5754-35-8 ]
[ 30562-34-6 ]
17-[2-(dioxolan-2-yl)ethyl]amino-17-demethoxygeldanamycin [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 5317 - 5329.

18
[ 5754-35-8 ]
[ 54644-12-1 ]
5-ethoxy-2-phenyl-oxazole-4-carboxylic acid (2-[1,3]dioxolan-2-yl-ethyl)-amide [ No CAS ]

References: [1]Tetrahedron,2006,vol. 62,p. 4698 - 4704.

19
[ 5754-35-8 ]
[ 463-71-8 ]
[ 1246860-85-4 ]

Yield	Reaction Conditions	Operation in experiment
100%	With calcium carbonate; In dichloromethane; water; at 20℃; for 18.0833h;	CaCO3 (1.36g, 13.66mmol) was added to a vigorously stirred solution of 2-[1 ,3]dioxolan- 2-yl-ethylamine (1.Og, 8.54mmol) in DCM (20ml) and water (10ml). Thiophosgene (0.85ml, 11.10mmol) was added dropwise over 5 min and the resultant biphasic mixture was vigorously stirred at RT for 18h. The reaction mixture was diluted with water (40ml) and the organic phase was separated. The aqueous layer was extracted with DCM (2 x 40ml) and the combined organic layers were washed with water (50ml) followed by brine (50ml), dried (Na2SO4) and concentrated in vacuo to give a yellow oil (1.36g, 100%). This material was used in the next step without further purification.

References: [1]Patent: WO2007/129048,2007,A1 .Location in patent: Page/Page column 35.

20
[ 5754-35-8 ]
[ 474759-03-0 ]

References: [1]Tetrahedron,2002,vol. 58,p. 4459 - 4479.

21
[ 18742-02-4 ]
[ 5754-35-8 ]

References: [1]Synthetic Communications,1987,vol. 17,p. 377 - 384.
[2]Journal of Organic Chemistry,1982,vol. 47,p. 4040 - 4045.
[3]Chemistry - A European Journal,2016,vol. 22,p. 7824 - 7836.
[4]Arkivoc,2019,vol. 2019,p. 178 - 195.

22
[ 5754-35-8 ]
[ 135833-79-3 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

23
[ 5754-35-8 ]
[ 110862-44-7 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

24
[ 5754-35-8 ]
[ 135833-80-6 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

25
[ 5754-35-8 ]
[ 104568-93-6 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

26
[ 5754-35-8 ]
[ 110862-43-6 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

27
[ 5754-35-8 ]
[ 104568-94-7 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

28
[ 5754-35-8 ]
[ 135833-89-5 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

29
[ 5754-35-8 ]
[ 135833-74-8 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

30
[ 5754-35-8 ]
[ 135833-71-5 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

31
[ 5754-35-8 ]
[ 104568-72-1 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

32
[ 5754-35-8 ]
1-(2-[1,3]Dioxolan-2-yl-ethyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.
[2]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

33
[ 5754-35-8 ]
[ 135833-76-0 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

34
[ 5754-35-8 ]
[ 135833-90-8 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

35
[ 5754-35-8 ]
[ 135833-91-9 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

36
[ 5754-35-8 ]
[ 110862-45-8 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

37
[ 5754-35-8 ]
[ 135833-78-2 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 357 - 366.

38
[ 5754-35-8 ]
[ 32315-10-9 ]
[ 134-20-3 ]
2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With triethylamine; In dichloromethane; ethyl acetate;	Example 4 2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic Acid Methyl Ester Methylanthranilate (1.18 g, 7.79 mmol) and triethylamine (2.5 mL, 17.7 mmol) in methylene chloride (10 mL) were cooled in an ice bath. Triphosgene (0.69 g, 2.34 mmol) in methylene chloride (10 ml) was added dropwise over 10 minutes. and the resulting mixture was stirred for 1 hour at 0 C. to form the isocyanate intermediate. 2-(2-Aminoethyl)-1,3-dioxolane(2.00 g, 17.1 mmol) in methylene chloride (10 ml) was added dropwise at 0 C. over 10 minutes., then the mixture was warmed to ambient temperature and stirred for 15 hours. Concentration yielded a yellow solid which was taken up in ethyl acetate and sat. sodium bicarbonate solution; the layers were separated. The organic layer was washed with brine, dried over magnesium sulfate. Concentration yielded 2-[3-(2-[1,3]dioxolan-2-yl-ethyl)-ureido]-benzoic acid methyl ester (1.26 g, 60%) as a white solid. 1H NMR CDCl3 delta 10.26 (brd s, 1H), 8.51-8.44 (m, 1H), 7.95 (dd, J=2, 8 Hz, 1H), 7.49-7.44 (m, 1H), 6.95-6.91 (m, 1H), 5.35-5.10(brd s, 1H), 4.95 (t, J=4 Hz, 1H), 4.01-3.98 (m, 2H), 3.88 (S, 3H), 3.87-3.82 (m, 2H), 3.44 (t, J=6 Hz, 2H), 1.96-1.92 (m, 2H).

References: [1]Patent: US2002/52355,2002,A1 .
[2]Patent: EP1178048,2002,A1 .Location in patent: Example 4.

39
[ 5754-35-8 ]
[ 128071-75-0 ]
[ 332881-75-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; sodium tris(acetoxy)borohydride; In acetic acid; 1,2-dichloro-ethane;	Step A N-((2-Bromo(3-pyridyl))methyl)-<strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethylamine</strong> To a solution of 2-bromopyridine-3-carbaldehyde (3.53 g, 19.0 mmol, 1.0 eq) (Melnyk et al., Synthetic Commun. 23(19):2727-2730, 1993) in 1,2-dichloroethane (50 mL) was added <strong>[5754-35-8]2-(1,3-dioxolan-2-yl)ethylamine</strong> (TCI-GR, 2.67 g, 22.8 mmol, 1.2 eq), sodium triacetoxyborohydride (Aldrich, 1.61 g, 76 mmol, 4.0 eq) and glacial acetic acid (1.14 g, 19 mmol, 1.0 eq). The reaction mixture was stirred under nitrogen at room temperature for 2 h. The reaction was quenched with 1.0 N aqueous NaOH to about pH 8 and the solution was extracted with EtOAc (200 mL*3). The organic extracts were washed with saturated NaCl, dried with MgSO4, filtered and concentrated. Flash column chromatography (silica gel, 0-10% EtOAc-Hexane) afforded the title compound as a colorless oil. MS m/z 377 (Br=79, M+H), 379 (Br=81, M+H).

References: [1]Patent: US6514964,2003,B1 .

40
[ 18742-02-4 ]
NH₂NH_2.H₂O [ No CAS ]
Bu₄N+HSO₄- [ No CAS ]
[ 1074-82-4 ]
[ 5754-35-8 ]

Yield	Reaction Conditions	Operation in experiment
73%	In ethanol; toluene;	A) 2-(2-Aminoethyl)-1,3-dioxolane A suspension of 50 g of 2-(2-bromoethyl)-1,3-dioxolane (product known in literature, CAS RN = 5754-35-8) (0.27 mL, 32.5 mol), 62.5 g of potassium phthalimide (0.34 mol), 9.16 g of Bu4N+HSO4- (0.027 mol) in 150 ml of toluene was heated to 100C and under N2 stream for 3 h. After cooling to room temperature, the mixture was filtered and evaporated to dryness. By crystallization of the residue from abs. EtOH the phthalimido derivative was obtained. A solution of 58.5 g of NH2NH2.H2O (1.17 ml; 56.8 mol), 64.36 g of phthalimido derivative (0.26 mol) in 2 l of abs. EtOH was heated to reflux under N2 stream for 2.5 h. After cooling to 0C, the precipitated phthalhydrazide was filtered through a sintered funnel. By evaporation of the filtrate to dryness, 23.26 g of the desired product (0.198 mol) were obtained. Yield: 73% The 1H-NMR, 13C-NMR, IR and MS spectra are consistent with the indicated structure.

References: [1]Patent: EP760683,2000,B1 .

41
[ 5754-35-8 ]
[ 124628-32-6 ]
[ 170728-43-5 ]

Yield	Reaction Conditions	Operation in experiment
66%	With triethylamine; In chloroform;	A) 2-Chloro-N-[2-(1,3-dioxolan-2-yl)ethyl]-3-phenylmethoxypropanamide A solution of 69.63 g of 2-chloro-3-(phenylmethoxy)propanoyl chloride (prepared according to the procedure described in Inorg. Chem., 31. 2422, 1992) (0.299 mol) in 90 ml of CHCl3 was added to a solution of 35.49 g of <strong>[5754-35-8]2-(2-aminoethyl)-1,3-dioxolane</strong> (prepared according to the procedure described in EXAMPLE 4) (0.303 mol) and to 60.3 g of triethylamine (83 ml; 0.596 mol) in 100 ml of CHCl3 under inert atmosphere, keeping the temperature at 0-5C. The reaction mixture was stirred for 5 h at 25C, then was washed with H2O. The organic phase was dried and evaporated to dryness, the residue was purified by flash chromatography. 61.68 g of the desired product (0.197 mol) were obtained. Yield: 66% TLC: Carrier: silica gel plates 60 F254 Merck Eluent: AcOEt: n-hexane = 1:1 (v/v)

References: [1]Patent: EP760683,2000,B1 .

42
[ 5754-35-8 ]
[ 935440-23-6 ]
[ 935440-34-9 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In tert-butyl methyl ether; at 20℃; for 1h;	To a solution of 660 mg of 2-aminomethyl-l, 3-dioxolan in 20 mL of tert-butylmethyl ether were added 0.33 mL of triethylamine and then 614 mg of N- [2-fluoro-4- (trifluoromethylthio) phenyl] -N-methylcarbamoyl chloride, and stirred at room temperature for an hour. The reaction solution was washed sequentially with water and a saturated saline solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by medium pressure preparative high performance liquid chromatography (hexane : ethyl acetate = 50 : 50) to give 600 mg of 3- [( 1, 3-dioxolan-2-yl) methyl] -1- [2-fluoro-4- (trifluoromethylthio) phenyl] -1-methylurea .3- (1, 3-Dioxolan-2-yl)methyl] -1- [2-fluoro-4- (trifluoromethylthio) phenyl] -1-methylurea1H-NMR (CDCl3) ?(ppm) : 3.25 (3H, s) , 3.45 (2H, dd, J = 5.9,3.7 Hz) , 3.82-3.92 (4H, m) , 4.54 (IH, br) , 4.93 (IH, t, J = 3.7 Hz) , 7.38 (IH, t, J = 8.2 Hz) , 7.45-7.53 (2H, m) .

References: [1]Patent: WO2007/46513,2007,A2 .Location in patent: Page/Page column 210.

43
[ 5754-35-8 ]
[ 905971-91-7 ]
[ 905970-21-0 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 767 - 771.

44
[ 5754-35-8 ]
[ 1024500-44-4 ]
[ 1024500-49-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	In 1-methyl-pyrrolidin-2-one; at 50℃; for 1.5h;	Stage 1 - 4-(2-Chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-[2-(1 ,3-dioxolan-2- yl)ethyl]amino}pyrido[2,3-c/]pyrimidin-7(8/-/)-oneA solution of 4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)- pyrido[2,3-cf]pyrimidin-7(8H)-one (Intermediate F) (50 mg, 0.11 mmol) and 2- [1 ,3]dioxolan-2-yl-ethylamine (63 mg, 0.54 mmol) in NMP (5 ml.) was heated at 50 0C for 1.5 hours. Water (20 ml_) was added followed by EtOAc (20 ml_). The layers were separated and the organic phase washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography (0-50 % EtOAc in heptane) to afford the title compound (46 mg, 85 % yield). m/z 503 [M+H]+.

References: [1]Patent: WO2008/53158,2008,A1 .Location in patent: Page/Page column 64.

45
[ 5754-35-8 ]
[ 50-00-0 ]
[ 646-01-5 ]
[ 1185859-77-1 ]
C₂₆H₃₇N₃O₆S [ No CAS ]

References: [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898.

46
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 453-71-4 ]
C₂₉H₃₃FN₄O₈ [ No CAS ]

References: [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898.

47
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 1759-53-1 ]
C₂₆H₃₅N₃O₆ [ No CAS ]

References: [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898.

48
[ 5754-35-8 ]
[ 50-00-0 ]
[ 1185859-77-1 ]
[ 98-89-5 ]
C₂₉H₄₁N₃O₆ [ No CAS ]

References: [1]Journal of Organic Chemistry,2009,vol. 74,p. 6895 - 6898.

49
[ 5754-35-8 ]
3-anilino-5-{2-[(tetrahydro-2H-pyran-4-ylcarbonyl)amino]pyridin-4-yl}benzoic acid [ No CAS ]
N-{4-[3-anilino-5-([2-(1,3-dioxolan-2-yl)ethyl]amino}carbonyl)phenyl]pyridin-2-yl}tetrahydro-2H-pyran-4-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%		3-anilino-5-{2-[(tetrahydro-2H-pyran-4-ylcarbonyl)amino]pyridin-4-yl}benzoic acid (42 mg, 0.10 mmol) AND N [ (DIMETHYLAMINO) (3H- [1, 2,3] triazolo [4, 5-B] pyridin-3- yloxy) METHYLENE]-N-METHYLMETHANAMINIUM hexafluorophosphate (58 mg, 0.15 mmol) were dissolved in 3 ML of DMF. Diisopropylethylamine (35 muL, 0.20 mmol) was added dropwise and the solution stirred for lh at room temperature under nitrogen atmosphere. Then a solution of [2- (1, 3-dioxolan-2-yl) ethyl] amine (11.7 mg, 0.10 mmol) in DMF (0.5 mL) was slowly added and the mixture stirred at 20C for 15h. The solution was poured on a saturated aqueous solution OF NAHC03 (15 mL) and extracted with ethyl acetate. After concentration of the solvent under vacuum, the crude material was purified by HPLC. Yield: 52% (27 mg). 1H NMR (400 MHz, CDC13) : 8 8.79 (s, 1H), 8. 50 (s, 1H), 8. 24 (d, J=5.5 Hz, 1H), 7.56 (t, J= 1.7 Hz, 1H), 7.49 (t, J= 1.3 Hz, 1H), 7.37 (t, J= 1./ Hz, 1H), 7.28 (m, 3H), 7.13 (m, 2H), 7.07 (m, 1H), 7.01 (m, 1H), 6.16 (s, 1H), 5.00 (t, J = 4.2 Hz, 1H), 4.02 (m, 4H), 3.87 (m, 2H), 3.63 (m, 2H), 3. 48 (td, J= 11.4/2. 6 Hz, 2H), 2.57 (m, 1H), 2.02 (m, 2H), 1.93-1. 85 (m, 4H). 13C NMR (101 MHz, CDC13) : 8 173.31 (s, 1 C), 166.71 (s, 1 C), 152.05 (s, 1 C), 150.59 (s, 1 C), 147.62 (s, 1 C), 144.63 (s, 1 C), 141.92 (s, 1 C), 139.56 (s, 1 C), 136.87 (s, 1 C), 129.51 (s, 2 C), 122.11 (s, 1 C), 118.93 (s, 2 C), 118.07 (s, 1 C), 117.98 (s, 1 C), 117.18 (s, 1 C), 115.65 (s, 1 C), 111.97 (s, 1 C), 103.91 (s, 1 C), 67.03 (s, 2 C), 64.96 (s, 2 C), 42.97 (s, 1 C), 35.29 (s, 1 C), 32.31 (s, 1 C), 28.95 (s, 2 C). MS (ES) M/Z (M+1) : 517.

References: [1]Patent: WO2005/3123,2005,A1 .Location in patent: Page 35.

50
[ 5754-35-8 ]
[ 4440-33-9 ]
[ 1215194-50-5 ]

References: [1]Journal of the American Chemical Society,2010,vol. 132,p. 3244 - 3245.

51
[ 5754-35-8 ]
[ 13049-86-0 ]
C₁₆H₂₇NO₈ [ No CAS ]
C₁₆H₂₇NO₈ [ No CAS ]

References: [1]Journal of Organic Chemistry,2011,vol. 76,p. 6432 - 6437.

52
[ 5754-35-8 ]
[ 33821-61-3 ]
[ 1403498-94-1 ]

References: [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8948 - 8952,5.

53
[ 5754-35-8 ]
N-(3-(1H-imidazol-1-yl)propyl)-2-bromo-1,3-thiazole-5-carboxamide [ No CAS ]
C₁₅H₂₁N₅O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile; at 120℃;	General procedure: Example 6A (2 g, 6.35 mmol) and (4-fluorophenyl)methanamine (0.794 g, 6.35 mmol) in acetonitrile (10 ml) were stirred at 120 C overnight. The reaction mixture was cooled, concentrated, taken into ethyl acetate and washed with saturated aqueous NaHC03 and brine. The combined aqueous layers were extracted twice with ethyl acetate. The combined organic extracts were dried (MgS04) and filtered. The filtrate was concentrated until solid material precipitated. The mixture was filtered to provide the title compound.

References: [1]Patent: WO2013/170118,2013,A1 .Location in patent: Page/Page column 129.

54
[ 5754-35-8 ]
[ 5430-45-5 ]
[ 1538625-40-9 ]

References: [1]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627.

55
[ 5754-35-8 ]
[ 2398-37-0 ]
[ 1538625-25-0 ]

References: [1]Journal of the American Chemical Society,2014,vol. 136,p. 1617 - 1627.

Historical Records

Technical Information

• Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Hydride Reductions • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

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P378
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Code	Phrase
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H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 5754-35-8

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CAS No.: 5754-35-8

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[ 5754-35-8 ] Synthesis Path-Downstream 1~55

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