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Chemical Structure| 850689-36-0 Chemical Structure| 850689-36-0

Structure of 850689-36-0

Chemical Structure| 850689-36-0

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Product Details of [ 850689-36-0 ]

CAS No. :850689-36-0
Formula : C6H7BClNO2
M.W : 171.39
SMILES Code : NC1=C(Cl)C=CC(=C1)B(O)O
MDL No. :MFCD03095254

Safety of [ 850689-36-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 850689-36-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 850689-36-0 ]

[ 850689-36-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 850689-36-0 ]
  • [ 1111637-94-5 ]
  • C14H12ClN3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In acetonitrile; at 90℃;Inert atmosphere; Sealed tube; A solution of 19 (200 mg, 0.952 mmol) and 27 (162.8 mg, 0.952 mmol) in acetonitrile was added Na2CO3 (201.6 mg, 1.904 mmol). The reaction was degassed and purged with nitrogen for 10 min. Pd(dppf)Cl2 (38.8 mg, 0.0476 mmol) was added to the reaction. The reaction mass was degassed and purged with nitrogen for another 10 min. The reaction was heated to 90 C. under sealed conditions overnight, then allowed to cool to RT and diluted with chloroform. The organic layer was filtered through Celite and concentrated to get the crude, which was purified through flash chromatography by using 100-200 silica mesh. The compound was eluted at 2% methanol chloroform as off-white colour solid 28.
  • 2
  • [ 850689-36-0 ]
  • [ 1111637-94-5 ]
  • (E)-N-(2-chloro-5-(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)pent-2-enamide [ No CAS ]
 

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