Structure of 854952-58-2
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CAS No. : | 854952-58-2 |
Formula : | C18H14BNO2 |
M.W : | 287.12 |
SMILES Code : | OB(C1=CC2=C(C=C1)N(C3=CC=CC=C3)C4=C2C=CC=C4)O |
MDL No. : | MFCD12196936 |
InChI Key : | JWJQEUDGBZMPAX-UHFFFAOYSA-N |
Pubchem ID : | 51358450 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 22 |
Num. arom. heavy atoms | 19 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 2 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 90.61 |
TPSA ? Topological Polar Surface Area: Calculated from |
45.39 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
3.9 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.46 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
2.59 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.42 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.08 |
Log S (ESOL):? ESOL: Topological method implemented from |
-4.58 |
Solubility | 0.00748 mg/ml ; 0.000026 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
Log S (Ali)? Ali: Topological method implemented from |
-4.55 |
Solubility | 0.00807 mg/ml ; 0.0000281 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-5.54 |
Solubility | 0.000836 mg/ml ; 0.00000291 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
Yes |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
Yes |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
Yes |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.28 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
2.22 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 24 h; Inert atmosphere; Reflux | Round bottom flask was charged with 9-Phenyl-9H-carbazole-3-boronic acid 15g (52.25mmol), 4-chloro-Phenylboronicacid8.98g (57.47mmol) and the mixture of toluene (174ml) and the mixture was then dissolved in 21.66g of potassium carbonate (156.74 mmol) was added to a stirred aqueous solution of dissolved 87ml. Followed by adding thereto tetrakis triphenylphosphine palladium 1.20g (1.04mmol) was stirred and refluxed for 24 hours under a nitrogen atmosphere. After the end of the reaction the extract was concentrated to dryness and extracted with ethyl acetate and filtered through a magnesium sulfate, and the filtrate under reduced pressure. The product n- hexane / dichloromethane (6: 4 by volume) was purified by a silica gel column chromatography to give the intermediate (I) as 16.13g (85percent yield). |
85% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 24 h; Inert atmosphere; Reflux | Round bottom flask was charged with 9-Phenyl-9H-carbazole-3-boronic acid 15g (52.25mmol), 4-chloro-Phenylboronicacid 8.98g dissolved in an aqueous solution of potassium carbonate 21.66g (156.74mmol) was dissolved was added to (57.47mmol) in toluene (174ml) into theIt was added to 87ml and stirred. Here tetrakistriphenylphosphine palladium was added to 1.20g (1.04mmol) of nitrogen atmosphere It was stirred under reflux for 24 hours under a group. After completion of the reaction, magnesium sulfate, the extract was then extracted with ethyl acetateIt was dried, filtered and concentrated under reduced pressure to the filtrate. Silica gel with: a product n- hexane / dichloromethane (volume ratio 4 6)The desired compound was purified by column chromatography of the intermediate (I) to give a 16.13g (85percent yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
38% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water;Inert atmosphere; Heating; | In a three-necked flask equipped with a stirrer 2.50 g (6.23 mmol) of <strong>[57103-20-5]3,6-dibromo-9-phenylcarbazole</strong> (compound a), 1.79 g (6.23 mmol) of 9-phenylcarbazole-3-boronic acid (compound b), 41.6 ml of 2 M potassium carbonate (K2CO3) aqueous solution (83.2 mmol of potassium carbonate) and 125 ml of tetrahydrofuran (THF) were added and nitrogen bubbling was carried out for 1 hour. 350 mg (0.31 mmol) of tetrakis (triphenylphosphine)palladium (Pd (PPh 3) 4) was added thereto and heated and stirred overnight. The reaction solution was returned to room temperature and the solvent was distilled off. After adding dichloromethane to the residue and redissolving it, and then washed with a saturated saline solution. Anhydrous magnesium sulfate was added to the organic layer, and the organic layer was dried and filtered. After concentrating the filtrate, silica gel column chromatography (dichloromethane: hexane = 1: 4) was carried out, a target compound c was obtained in a yield of 1.32 g (0.24 mmol) in a yield of 38percent. |
32% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 80℃; for 16h;Inert atmosphere; | 100 g (348 mmol) of 9-phenyl-9H-carbazol-3-ylboronic acid was dissolved in 1.3 L of tetrahydrofuran (THF) in a nitrogen environment, 168 g (418 mmol) of <strong>[57103-20-5]3,6-dibromo-9-phenyl-9H-carbazole</strong> and 4.02 g, 3.48 mmol) of tetrakis(triphenylphosphine)palladium were added thereto, and the mixture was agitated. 102 g (696 mmol) of potassium carbonate saturated in water was added thereto, and the mixture was heated and refluxed at 80 °C for 16 hours. When the reaction was terminated, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM) and treated with anhydrous MgSO4 to remove moisture and then, filtered and concentrated under a reduced pressure. The obtained residue was separated and purified through flash column chromatography, obtaining a compound I-28 (62.8 g, 32 percent). HRMS (70 eV, EI+): m/z calcd for C36H23BrN2: 562.1045, found: 562.1. Elemental Analysis: C, 77 percent; H, 4 percent |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,2-dimethoxyethane; water; toluene; for 15.0h;Inert atmosphere; Reflux; | Under an argon atmosphere, 2.3g (8.06 mmol) of M-2, 279 mg (0.242 mmol) of tetrakis(triphenylphosphine)palladium(0) and 2.0g (8.06 mmol) of M-1 dissolved in 12 mL of dried toluene were placed in a three-necked flask. Further, 12 mL of dried dimethoxyethane and 12 mL of a 2M aqueous solution of sodium carbonate were added. The resulting mixture was heated under reflux while stirring for 15 hours. The reaction mixture was cooled to room temperature. After addition of water, the mixture was stirred for an hour at room temperature, followed by extraction with toluene. After separating, an organic layer was washed with saturated saline, and dried with anhydrous sodium sulfate. Under reduced pressure, the solvent is distilled away, and a residue was purified by silica-gel column chromatography to obtain 3.1g of intermediate 1 (yield: 92%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; for 12h;Inert atmosphere; Reflux; | A mixture of 3,3'-Dibromobenzophenone (386 mg, 1.14 mmol), 9-phenylcarbazol-3-bronic acid (800 mg, 2.78 mmol), 1.35 M potassium phosphate aq. (10 mL), xylene (20 mL) and ethanol (10 mL) was deoxygenated with nitrogen for 60 min. 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl (66 mg,0.16 mmol) and tris(dibenzylideneacetone) dipalladium(0) (73 mg, 0.08 mmol) was added. The reaction mixture was refluxed for 12 h. After cooling to room temperature, water was added. The aqueous layer was extracted with toluene. The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography (hexane:ethylacetate = 4:1 to 3:2) to give BCzBP as a white solid (584 mg, 77%). 1H NMR (400 MHz, DMSO) δ [ppm]: 8.65 (s, 2H), 8.30 (d, J = 8 Hz,2H), 8.21 (s, 2H), 8.13 (d, J = 8 Hz, 2H), 7.83-7.78 (m, 4H), 7.74-7.62 (m, 10H), 7.55 (t, J = 7 Hz,2H), 7.49-7.36 (m, 6H), 7.26 (t, J = 7 Hz, 2H). 13C NMR (400 MHz, CDCl ) δ [ppm]: 197.07, 3142.19, 141.32, 140.54, 138.20, 137.45, 132.22, 131.29, 129.92, 128.82, 128.77, 128.38, 127.57, 127.02, 126.24, 125.36, 123.93, 123.27, 120.41, 120.15, 118.98, 110.16, 109.92. Elemental anal.Calcd for C49H32N2O: C, 88.53; H, 4.85; N, 4.21. Found: C, 88.66; H, 4.84; N, 4.16. EI-MS (m/z):[M+H]+ calcd for C49H32N2O, 664; found, 666. Purity (determined by HPLC): 99.9%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88.7% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; for 12h;Reflux; | After introducing compound A (10-bromo-7H-benzo[cjcarbazole) (16 g, 54 mmol), (9-phenyl-9H-carbazol-3-yl)boronic acid (17 g, 59.4 mmol), Pd(PPh3)4 (3.1 g, 2.7 mmol), K2C03 (25.7 g, 108 mmol), distilled water (50 mL), toluene (250 mL), and ethanol(EtOH)(50 mL) in a flask, the mixture was stirred under reflux for 12 hours. After cooling to room temperature, the mixture was extracted with EA and distilled water, dried with magnesium sulfate, distilled under reduced pressure, and purified by column chromatography to obtain compound B(1 0-(9-phenyl-9H-carbazol-3-yl)-7H-benzo[cj carbazole) (22 g, yield: 88.7%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 12h;Reflux; | 10g (35 mmol) of the compound (9-phenyl-9H-carbazol-3-yl) boronic acid and 11.3 g (35 mmol) of 2,8-dibromodibenzo [b, d] furan were mixed and dissolved in 90 mL of tetrahydrofuran , And a solution prepared by dissolving 14.5 g (105 mmol) of potassium carbonate in 30 mL of water was added and warmed. 400 mg (0.35 mmol) of tetrakis- (triphenylphosphine) palladium was added to the refluxed mixture, and the mixture was refluxed and stirred for 12 hours. When the reaction is completed, the solvent is removed, and while cooling to room temperature, ethyl acetate is added to slurry. This was filtered and washed with water and ethanol successively to obtain 12.4 g (yield: 73percent) of a white compound H. |
65% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 80℃; for 16.5h;Inert atmosphere; | Example 1.13.17 3-(8-bromodibenzo[b,d]furan-2-yl)-9-phenyl-9H-carbazole (Compound 17) A mixture of (9-phenyl-9H-carbazol-3-yl)boronic acid (1.50 g, 5.22 mmol), <strong>[10016-52-1]2,8-dibromodibenzo[b,d]furan</strong> (2.98 g, 9.14 mmol), tetrakis(triphenylphosphine) palladium(0) (0.30 g, 0.26 mmol), potassium carbonate (2.17 g, 15.67 mmol), 1,4-dioxane (50.00 mL), and water (10.00 mL) was degassed with bubbling argon for 30 min. The reaction mixture was then heated to 80° C. and was stirred overnight (16.5 hours), maintaining an argon atmosphere. Consumption of the starting material was confirmed by thin-layer chromatography and the reaction was cooled to room temperature. The product was extracted with dichloromethane, dried, and purified by silica gel column chromatography with dichloromethane in hexanes as the eluent. The product fractions were then dried and the product was collected to yield Compound 17 (1.65 g, 65percent). Confirmed by LCMS (APCI): calculated for C30H18BrNO (M+H): 488. Found: 488. |
61% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In water; toluene; for 15h;Inert atmosphere; Reflux; | Under argon or nitrogen atmosphere at 65.2 g (200 mM)2,8-Dibromodibenzo[b,d]furan, 60.3 g (210 mM)(9-Phenyl-9H-carbazol-3-yl)boronic acid,4.7 g (4 mM) of tetrakis(triphenylphosphine)palladium(0)600 ml of toluene and 300 ml of a 2M Na2CO3 aqueous solution were added and the mixture was heated while refluxing for 15 hours.After completion of the reaction, extraction was performed using dichloromethane and placed in MgSO 4 for filtration.After removing the solvent of the filtered organic layer, purification was performed by column chromatography to obtain 58.7 g of Intermediate I-1(3-(8-Bromodibenzo[b,d]furan-2-yl)-9-phenyl-9H-carbazole) (yield 61percent) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | The Bl (3.34g, 10 mmol) was added vial, the injection of THF dried, placed in a dry ice - acetone bath cooling, -78 ° C was added dropwise n-BuLi (1 lmmol, 2.5M) solution, stirring was continued for 3 hours and then triisopropyl borate (2.07g, 11 mmol) added to the bottle, slowly brought to room temperature and stirred overnight. After completion of the reaction, dilute HC1 solution was dropwise jerk, and extracted with methylene chloride, the organic layer was dried, solvent was removed, dichloromethane and petroleum ether (60-90) was washed with a mixture of beating to give D-1 (2.57g, y = 86percent), |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; at 90℃;Inert atmosphere; | General procedure: A small molecule luminescent material (P37) based on 1,2-diphenylacetylene as the acceptor unit,The specific steps are:Under nitrogen protection,To a three-necked flask was added 100 ml of toluene,1 g of intermediate 1 (2.99 mmol),2.14 g of 9-phenyl-3-carbazole boronic acid (7.45 mmol, 2.5 equ)Under stirring, 3.47 g of sodium tert-butyl alcohol was added,Then add 230 mg of palladium acetate,0.5 mL of tri-tert-butylphosphine,90 & lt; 0 & gt; C overnight.Cooling, extraction of organic phase with methylene chloride, spin dry,Column. To give 1.48 g of product as a yellow solid in 75% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In tetrahydrofuran; water; at 80℃; | Intermediate I-3 (10 g, 39.2 mmol), (9-phenyl-9H-indazol-3-yl)boronic acid (11.3 g, 39.2 mmol), tetratriphenylphosphine palladium (1.4) was added to a round bottom flask. g, 1.2 mmol), a mixed solvent of sodium hydroxide (3.9 g, 98 mmol) and tetrahydrofuran (200 mL) and deionized water (100 mL). The reaction system was heated to reflux at 80 C. After the reaction was completed, it was cooled to room temperature, and the reaction liquid was diluted with distilled water. The reaction mixture was then extracted with dichloromethane and water. Purification by column chromatography on silica gel afforded Intermediate-1 (14.5 g, 80%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 70 - 90℃;Inert atmosphere; | In a 100 mL three-necked flask, put 2,7-dibromooxanthracene (3.42g, 10mmol),(9-Phenyl-9H-carbazol-3-yl)boronic acid (6.32g, 22mmol), potassium carbonate (2.76g, 20mol), based on the amount of 2,7-dibromoxanthracene, add2-3 times the volume of toluene, 1-1.5 times the volume of ethanol and 1-1.5 times the volume of water, in a nitrogen atmosphere,Add tetrakis(triphenylphosphine) palladium (0.03g, 0.02mmol), increase the temperature to 70-90C and react for 6-18h, monitor the completion of the reaction in the liquid phase, cool to room temperature,The reaction solution is filtered, the organic phase is concentrated, and the sample is mixed with the filter cake and passed through a silica gel column, washed with a 10:1 mixture of petroleum ether and dichloromethane, and the eluent is concentrated to obtain 4.00g of the target compound (340) , The yield is 60%. |
Tags: 854952-58-2 synthesis path| 854952-58-2 SDS| 854952-58-2 COA| 854952-58-2 purity| 854952-58-2 application| 854952-58-2 NMR| 854952-58-2 COA| 854952-58-2 structure
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Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
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Code | Phrase |
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Code | Phrase |
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P378 | |
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P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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