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[ CAS No. 25032-74-0 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 25032-74-0
Chemical Structure| 25032-74-0
Chemical Structure| 25032-74-0
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Product Details of [ 25032-74-0 ]

CAS No. :25032-74-0 MDL No. :MFCD00458551
Formula : C13H8Br2O Boiling Point : -
Linear Structure Formula :- InChI Key :QBNTVYGGZGPJDZ-UHFFFAOYSA-N
M.W : 340.01 Pubchem ID :12731928
Synonyms :

Calculated chemistry of [ 25032-74-0 ]

Physicochemical Properties

Num. heavy atoms : 16
Num. arom. heavy atoms : 12
Fraction Csp3 : 0.0
Num. rotatable bonds : 2
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 71.72
TPSA : 17.07 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -4.95 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.88
Log Po/w (XLOGP3) : 4.82
Log Po/w (WLOGP) : 4.44
Log Po/w (MLOGP) : 4.3
Log Po/w (SILICOS-IT) : 4.73
Consensus Log Po/w : 4.23

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -5.41
Solubility : 0.00133 mg/ml ; 0.00000391 mol/l
Class : Moderately soluble
Log S (Ali) : -4.91
Solubility : 0.00417 mg/ml ; 0.0000123 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -6.53
Solubility : 0.0000994 mg/ml ; 0.000000292 mol/l
Class : Poorly soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.74

Safety of [ 25032-74-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25032-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25032-74-0 ]

[ 25032-74-0 ] Synthesis Path-Downstream   1~85

  • 2
  • [ 6952-59-6 ]
  • [ 108-36-1 ]
  • [ 25032-74-0 ]
  • 1,3-bis-(3-bromo-benzoyl)-benzene [ No CAS ]
  • 3
  • [ 25032-74-0 ]
  • tetrakis-(3-bromo-phenyl)-ethane-1,2-diol [ No CAS ]
  • 4
  • [ 25032-74-0 ]
  • [ 51339-30-1 ]
YieldReaction ConditionsOperation in experiment
88% With pyridinium chlorochromate; In dichloromethane; for 1.5h;Molecular sieve; Next, 200 mL Erlenmeyer flask was charged with Celite8.5 g,3.4 g of active molecular sieves 3A, 60 ml of dichloromethane,2.72 g (12.6 mmol) of pyridinium chlorochromate was added and stirred.Compound h 1.44 g (4.21 mmol) of dichloromethane 10 mlAfter adding the solution, the mixture was stirred for 1.5 hours. For the reaction mixture,The insoluble portion was removed with an alumina short column. After concentration of the filtrate,The obtained viscous substance was purified by silica gel column chromatography (hexane: ethyl acetate = 9: 1) to obtain 1.26 g (3.71 mmol) of the target compound i,Obtained in 88% yield.
  • 5
  • [ 119-61-9 ]
  • [ 25032-74-0 ]
  • [ 1016-77-9 ]
  • 6
  • [ 25032-74-0 ]
  • [ 544-92-3 ]
  • [ 75896-85-4 ]
  • 7
  • [ 25032-74-0 ]
  • [ 1066-54-2 ]
  • [ 130249-08-0 ]
  • 8
  • [ 25032-74-0 ]
  • [ 504-63-2 ]
  • [ 130201-37-5 ]
  • 9
  • [ 6952-59-6 ]
  • Grignard's compound from 1.3-dibromo-benzene [ No CAS ]
  • [ 25032-74-0 ]
  • 1,3-bis-(3-bromo-benzoyl)-benzene [ No CAS ]
  • 10
  • [ 115-77-5 ]
  • [ 25032-74-0 ]
  • 3,3,9,9-tetrakis(3-bromophenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane [ No CAS ]
  • 11
  • [ 25032-74-0 ]
  • [ 6328-61-6 ]
  • 1,1-diphenyl-2,2-di(m-bromophenyl)ethylene [ No CAS ]
  • 12
  • [ 25032-74-0 ]
  • [ 6328-61-6 ]
  • [ 859315-37-0 ]
  • 13
  • [ 25032-74-0 ]
  • [ 7385-10-6 ]
  • 9-bis(3-bromophenyl)methylene-9H-fluorene [ No CAS ]
  • 14
  • [ 51339-30-1 ]
  • [ 25032-74-0 ]
YieldReaction ConditionsOperation in experiment
88% With pyridinium chlorochromate; In dichloromethane; at 20℃; for 1.5h; A mixture of pyridiniumchlofochromate (2.72 g, 12.6 mmol) in dichloromethane (60 mL) was added a solution of 3,3'-Dibromophenylmethanol in dichloromethane (10 mL). The resulting mixture was stirred 1.5 h at room temperature. The organic layer was concentrated under reduced pressure and the crude product purified by silica gel column chromatography (hexane:ethylacetate = 9:1) to give 2 as a pale yellow solid. (1.26 g, 88%).
85% With pyridinium chlorochromate; In dichloromethane; at 0 - 20℃; for 5.66667h; Bis(3-bromophenyl) ketone. 30 mL of anhydrous CH2Cl2 were poured into a flask containing PCC (1.92 g, 8.73 mmol) and celite (1.9 g). The suspension was stirred at 0 C. under nitrogen for 10 minutes, at which point, 10 mL of a CH2Cl2 solution of the appropriate alcohol (1.99 g, 5.82 mmol) were added. After the reaction was stirred at room temperature for 5.5 h, 15 mL of Et2O were added and the reaction mixture was filtered through fluorisil-silica gel and rinsed with extra Et2O (10 mL). The organic phase was dried under Na2SO4 and the solvent was evaporated to afford 1.673 g (4.92 mmol) of pure product in a 85% yield.1H NMR (300 MHz, CDCl3, δ): 7.92 (t, J=1.8, ArH, 2H), 7.73 (ddd, J=8.0, 2.0, 1.1, ArH, 2H), 7.68 (ddd, J=7.7, 1.6, 1.2, ArH, 2H), 7.37 (t, J=7.8, ArH, 2H).13C NMR (75 MHz, CDCl3): δ 193.7, 138.8, 135.7, 132.7, 130.0, 128.5, 122.8.
76.8% With pyridinium chlorochromate; In dichloromethane; at 20℃; for 12h; In a 5 L round bottom flask, 150 mL of methylene chloride was added to 10 g (0.05 mol) of the compound represented by the formula [1-b] obtained from the scheme 2, and pyridinium chlorochromate25.7 g was dissolved in 200 mL of methylene chloride and added to the reaction.The mixture was stirred at room temperature for 12 hours. After completion of the reaction, 900 mL of ethanol was added and stirred, followed by filtration. The organic layer was concentrated under reduced pressure and then dried to obtain 7.6 g (76.8%) of a compound represented by the formula 1-c
72% With dipyridinium dichromate; In dichloromethane; at 0 - 25℃; for 3h; The product obtained in step (1) was added to dry dichloromethane (DCM) (75mL), dissolved at room temperature with stirring, then cooled to 0C, and pyridinium dichromate (PDC) (12.4g, 32.96) was slowly added. mmol), the reaction mixture was stirred at room temperature for 3 hours.At the end of the reaction, H2O and ethyl acetate (EA) (the mass ratio ofH2O: EA is 1:1) are added for extraction, the organic phases are combined, dried with anhydrous Na2SO4,and then removed by a rotary evaporator. The solvent was removed to obtain the crude product.The crude product was purified by column chromatography (silica gel column, eluent PE:EA=50:1, volume ratio) to obtain a white powder as the product with a yield of 72%.
With manganese(IV) oxide; In dichloromethane; at 20℃; for 1h; Under a nitrogen atomosphere, a tetrahydrofuran solution (10 mL) of 1,3-dibromobenzene (1.9 mL, 16.1 mmol) was cooled to -70 C. and then n-butyllithium (10.0 mL, 1.60 N, 16.1 mmol) was added dropwise thereto over a period of 15 minutes. After the mixture was stirred at -70 C. additionally for 20 minutes, a tetrahydrofuran (10 mL) solution of 3-bromobenzaldehyde (1.7 mL, 14.6 mmol) was added dropwise over a period of 15 minutes, and the mixture after the dropwise addition was allowed to warm to room temperature. The reaction solution was poured into aqueous ammonium chloride-saturated solution, and the mixture was extracted with toluene. The organic phases obtained were combined and concentrated to give 1,1-bis(3-bromophenyl)methanol as a colorless oily substance. The substance was used in the next reaction without further purification. Manganese dioxide (14.2 g, 146.0 mmol) was added to a methylene chloride (70 mL) solution of 1,1-bis(3-bromophenyl)methanol (14.6 mmol) and the mixture was stirred at room temperature in air for 1 hour. The reaction solution was filtered. The filtrate was concentrated and the residue obtained was purified by silica gel column chromatography and recrystallization to give 3,3'-dibromobenzophenone as white powder (3.5 g). Yield: 70.5%. 1H-NMR (200 MHz, CDCl3) δ: 7.38 (t, J=8.0 Hz, 2H), 7.65-7.79 (m, 4H), and 7.93 (dd, J=1.6, 2.0 Hz, 2H).

  • 15
  • [ 25032-74-0 ]
  • [ 79-19-6 ]
  • bis(3-bromophenyl) ketone thiosemicarbazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
18% Bis(3-bromophenyl) ketone thiosemicarbazone (14) Into a round bottom flask containing the appropriate ketone (1.044 g, 3.07 mmol), 35 mL of anhydrous methanol were added and the solution was refluxed for about 15 minutes. To the warm ketone solution, thiosemicarbazide (0.294 g, 3.23 mmol) and 1% solution of HOAc (1.5 mL) were added. The reaction mixture was refluxed under nitrogen atmosphere for 46 h, at which point, the solvent was evaporated and, the crude reaction mixture was purified by flash chromatography (20% EtOAc/80% hex) to obtain 0.231 g (0.559 mmol) of the product in an 18% yield.1H NMR (360 MHz, CDCl3, δ): 8.59 (br s, NH, 1H), 7.72 (s, ArH, 2H), 7.41 (m, ArH, 6H), 6.92 (br s, NH2, 1H).
  • 16
  • [ 3132-99-8 ]
  • ethyl 2-halogeno-acetate [ No CAS ]
  • [ 25032-74-0 ]
  • 19
  • [ 2592-86-1 ]
  • [ 25032-74-0 ]
  • 20
  • [ 25032-74-0 ]
  • [ 493015-39-7 ]
  • 21
  • [ 25032-74-0 ]
  • [ 130249-12-6 ]
  • 22
  • [ 25032-74-0 ]
  • [ 130248-98-5 ]
  • 23
  • [ 25032-74-0 ]
  • carbonylbis[3-(pyridin-2-yl)benzene] [ No CAS ]
YieldReaction ConditionsOperation in experiment
75.8% In a nitrogen atmosphere, a n-pentane solution of t-butyllithium (17.8 ml, 1.60M, 28.5 mmol) was dropwise added to tetrahydrofuran cooled to -70C, then a tetrahydrofuran (5 ml) solution of 2-bromopyridine (1.2 ml, 12.9 mmol) was added thereto while 15 minutes, after a dropwise, the mixture was stirred at -70C for 30 minutes. Then, a tetrahydrofuran solution of zinc chloride (31.8 ml, 0.50 M, 15.9 mmol) was added to the mixture while 10 minutes. Thereafter, the temperature of the reaction mixture was allowed to warm to room temperature while 1 hour, tetrakis(triphenylphosphine)palladium (203 mg) and <strong>[25032-74-0]3,3'-dibromobenzophenone</strong> (2.0 g, 5.88 mmol) were successively added thereto, the reaction mixture was stirred under reflux for 18 hours. After the reaction mixture was allowed to cool, then the mixture was poured into a mixture of ethylenediaminetetraacetic acid (7.0 g)/an aqueous saturated sodium hydrogen carbonate solution (210 ml), an organic layer was separated, furthermore an aqueous layer was extracted with toluene. The organic layer was combined, and the solvent was distilled off, and the residue was purified by silica gel column chromatography and recrystallization, thereby obtaining 1.5 g of carbonylbis[3-(2-pyridyl)benzene as white powder. Yield: 75.8%. 1H-NMR (CDCl3)δ: 7.22-7.34(m, 2H), 7.62(dt, J=0.4, 7.8Hz, 2H), 7.74-7.84(m, 4H), 7.88(dt, J=7.8, 1.4HZ, 2H), 8.30(ddd, J=1.4, 1.8, 7.6Hz, 2H), 8.45(t, J=1.6Hz, 2H), 8.71(dt, J=4.4, 1.6HZ, 2H)
  • 24
  • [ 25032-74-0 ]
  • [ 1779-49-3 ]
  • [ 29265-85-8 ]
YieldReaction ConditionsOperation in experiment
2.2 g (78.6%) With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; EXAMPLE 37 A suspension of methyltriphenylphosphonium bromide (3.25 g; 9.05 mmol) in 100 ml of ether was added at 0 C. n-butyllithium in hexane (3.7 ml; 9.05 mmol) and the mixture was allowed to stir at room temperature for 1 h. To the above mixture was added 2.8 g (8.2 mmol) of 1,1-di(m-bromophenyl)ketone in 30 ml of tetrahydrofuran and the mixture was stirred for 10 min. The above reaction mixture was quenched with acetone (5 ml), stirred for 5 minutes, filtered, and the filtrate was concentrated in vacuo. The residue in hexane/methylene chloride (3:1) was purified by chromatography on silica eluding with hexane to afford 2.2 g (78.6%) of 1,1-di(m-bromophenyl)ethylene (Formula III: R2 =R3 =H;R4 =R5 =3-Br-phenyl).
2.2 g (78.6%) With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; (a) To a suspension of methyltriphenylphosphonium bromide (3.25 g; 9.05 mmol) in 100 mL of ether was added at 0 C. n-butyllithium in hexane (3.7 mL; 9.05 mmol) and the mixture was heated to stir at room temperature for 1 h. To the above mixture was added 2.8 g (8.2 mmol) of 1,1-di(m-bromophenyl)ketone in 30 mL of tetrahydrofuran and the mixture was stirred for 10 min. The above reaction mixture was quenched with acetone (5 mL), stirred for 5 minutes, filtered, and the filtrate was concentrated in vacuo. The residue in hexane/methylene chloride (3:1) was purified by chromatography on silica eluding with hexane to afford 2.2 g (78.6%) of 1,1-di(m-bromophenyl)ethylene (Formula III: R3 =R4 =H; R5 =R6 =3--Br-phenyl).
  • 25
  • [ 288-13-1 ]
  • [ 25032-74-0 ]
  • carbonylbis[3-(1-pyrazolyl)benzene] [ No CAS ]
YieldReaction ConditionsOperation in experiment
64.9% With (E)-2-hydroxylbenzaldehyde oxime; caesium carbonate;copper(I) oxide; In acetonitrile; for 24h;Heating / reflux; A mixture of <strong>[25032-74-0]3,3'-dibromobenzophenone</strong> (3.0 g, 8.8 mmol), pyrazole (1.5 g, 22.1 mmol), cesium carbonate (8.6 g, 26.5 mmol), cuprous oxide (126 mg), salicylaldoxime (484 mg) and acetonitrile (20 mL) was stirred in reflux condition under nitrogen atmosphere for 24 hours. The reaction solution obtained was allowed to cool to room temperature. Water and toluene were added thereto and the extraction was carried out. The organic phases obtained were combined and concentrated. The residue obtained was purified by silica gel column chromatography and recrystallization to give carbonyl bis[3-(1-pyrazolyl)benzene] as white powder (1.8 g). Yield: 64.9%. 1H-NMR (200 MHz, CDCl3) δ: 6.51 (dt, J=0.6, 1.8 Hz, 2H), 7.60 (t, J=7.7 Hz, 2H), 7.68-7.78 (m, 4H), 7.98-8.08 (m, 4H), and 8.12-8.18 (m, 2H).
  • 26
  • C13H8Br2S [ No CAS ]
  • [ 263249-05-4 ]
  • [ 25032-74-0 ]
  • 27
  • [ 25032-74-0 ]
  • [ 263249-05-4 ]
  • 28
  • [ 13431-34-0 ]
  • [ 25032-74-0 ]
  • [ 1220124-33-3 ]
  • 29
  • [ 25032-74-0 ]
  • [ 13431-41-9 ]
  • [ 1220124-32-2 ]
  • 30
  • [ 25032-74-0 ]
  • [ 5351-69-9 ]
  • [ 1220124-31-1 ]
  • 31
  • [ 110-71-4 ]
  • [ 2052-07-5 ]
  • [ 25032-74-0 ]
  • [ 106-93-4 ]
  • [ 1211547-22-6 ]
YieldReaction ConditionsOperation in experiment
With hydrogen bromide; magnesium; In tetrahydrofuran; acetic acid; toluene; A) 9,9-Bis(3-bromophenyl)-9H-fluorene 62.9 g (270 mmol) of 2-bromobiphenyl mixed with 400 ml of THF, 550 ml of toluene, 45 ml of 1,2-dimethoxyethane and 2.6 ml of 1,2-dibromoethane are reacted with 6.6 g (250 mmol) of magnesium to give the corresponding Grignard compound. A solution of 60.0 g (176 mmol) of bis(3-bromophenyl) ketone in 600 ml of THF is added dropwise to the cooled Grignard solution. When the addition is complete, the reaction mixture is heated under reflux for 4 h, the solvent is then removed in vacuo, the residue is dissolved in 700 ml of glacial acetic acid, 10 ml of hydrogen bromide in 30% glacial acetic acid are added, and the mixture is heated under reflux for 6 h. After cooling with stirring, the precipitated solid is filtered off with suction, washed twice with 200 ml of glacial acetic acid each time and three times with 300 ml of ethanol each time and then dried in vacuo. Yield: 69.0 g (145 mmol), 82.1%, 99% pure according to 1H-NMR.
  • 32
  • [ 25032-74-0 ]
  • [ 1270278-03-9 ]
  • 33
  • [ 25032-74-0 ]
  • [ 1270278-04-0 ]
  • 35
  • [ 25032-74-0 ]
  • [ 1569852-62-5 ]
  • 36
  • [ 25032-74-0 ]
  • [ 1569852-68-1 ]
  • 37
  • [ 25032-74-0 ]
  • [ 1569852-74-9 ]
  • 38
  • [ 25032-74-0 ]
  • [ 1569852-71-6 ]
  • 39
  • [ 854952-58-2 ]
  • [ 25032-74-0 ]
  • 3,3'-bis(9-phenyl-9H-carbazol-3-yl)benzophenone [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; for 12h;Inert atmosphere; Reflux; A mixture of 3,3'-Dibromobenzophenone (386 mg, 1.14 mmol), 9-phenylcarbazol-3-bronic acid (800 mg, 2.78 mmol), 1.35 M potassium phosphate aq. (10 mL), xylene (20 mL) and ethanol (10 mL) was deoxygenated with nitrogen for 60 min. 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl (66 mg,0.16 mmol) and tris(dibenzylideneacetone) dipalladium(0) (73 mg, 0.08 mmol) was added. The reaction mixture was refluxed for 12 h. After cooling to room temperature, water was added. The aqueous layer was extracted with toluene. The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel column chromatography (hexane:ethylacetate = 4:1 to 3:2) to give BCzBP as a white solid (584 mg, 77%). 1H NMR (400 MHz, DMSO) δ [ppm]: 8.65 (s, 2H), 8.30 (d, J = 8 Hz,2H), 8.21 (s, 2H), 8.13 (d, J = 8 Hz, 2H), 7.83-7.78 (m, 4H), 7.74-7.62 (m, 10H), 7.55 (t, J = 7 Hz,2H), 7.49-7.36 (m, 6H), 7.26 (t, J = 7 Hz, 2H). 13C NMR (400 MHz, CDCl ) δ [ppm]: 197.07, 3142.19, 141.32, 140.54, 138.20, 137.45, 132.22, 131.29, 129.92, 128.82, 128.77, 128.38, 127.57, 127.02, 126.24, 125.36, 123.93, 123.27, 120.41, 120.15, 118.98, 110.16, 109.92. Elemental anal.Calcd for C49H32N2O: C, 88.53; H, 4.85; N, 4.21. Found: C, 88.66; H, 4.84; N, 4.16. EI-MS (m/z):[M+H]+ calcd for C49H32N2O, 664; found, 666. Purity (determined by HPLC): 99.9%.
  • 41
  • [ 25032-74-0 ]
  • C56H36 [ No CAS ]
  • 43
  • [ 25032-74-0 ]
  • 9,9'-((9H-thioxanthene-9,9-diyl)bis(3,1-phenylene))bis(9H-carbazole) [ No CAS ]
  • 44
  • [ 25032-74-0 ]
  • 9,9'-Bis(3-(9H-carbazol-9-yl)phenyl)-9H-thioxanthene-10,10-dioxide [ No CAS ]
  • 46
  • [ 25032-74-0 ]
  • 9,9-bis(3-bromophenyl)-9H-thioxanthene-10,10-dioxide [ No CAS ]
  • 47
  • [ 3132-99-8 ]
  • [ 108-36-1 ]
  • [ 25032-74-0 ]
YieldReaction ConditionsOperation in experiment
42% A 300 mL three-necked flask was charged with 1.21 ml (9.96 mmol) of the compound f,150 ml of dehydrated diethyl ether was added, and under a nitrogen atmosphereAnd the mixture was stirred at -70 C. or lower. N-Butyl lithium 6.0 ml (1.65 mol / l n-hexane solution,9.90 mmol) was added at -70 C. or less within 60 minutes, and the mixture was stirred for 2 hours.A solution of 0.29 ml (11.0 mmol) of compound g in 30 ml of dehydrated diethyl etherThe solution was added all at once and then stirred for a further 2 hours. After returning the reaction mixture to room temperature,100 ml of methanol was added to terminate the reaction. After distilling off the solvent,The obtained viscous substance was purified by silica gel column chromatography (hexane: ethyl acetate = 9: 1) to obtain 1.44 g (4.21 mmol) of the objective compound h,It was obtained in a yield of 42%.
  • 48
  • [ 108-36-1 ]
  • [ 79-44-7 ]
  • [ 25032-74-0 ]
YieldReaction ConditionsOperation in experiment
76% 1,3- dibromobenzenes (59.0 g, 250 mmol) aredissolved among the diethylether of 1.1 l and it cools to -65.The n-BuLi solution (2.5 M among the n-hexane) of 100 ml is dipped as thegradually and the mixture is stirred for the additional 1 hour. The N,N-dimethylcarbamoyl chloride is added under the fierce mixingat a time. In -65 the mixture, it heats to the gradually for 1 hourafter doing the mixing. Subsequently, the mixture of the acetic acid of thewater of 250 ml and 25 ml are dipped as the gradually. The product isprecipitated as the white solid. Solid is filtered to the suction andit rinses in fresh water after washing to water and ethanol. The yield is 42.2 g(76% of the Theoretical value) as the white solid
  • 49
  • [ 25032-74-0 ]
  • [ 7025-06-1 ]
  • 9,9-bis(3-bromophenyl)-9H-xanthene [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% First, magnesiums (3.17 g, 120.6 mmol) areintroduced to the flask including one iodine crystal. First, 1- bromo -2-phenoxy benzenes (23.2 g, 93.2 mmol), the anhydrous tetrahydrofuran of 190 ml,and 1,2- dimethoxyethane of 26 ml and 1,2- dichloroethane of 0.78 ml areintroduced to the dropping funnel. The outbound - material blend is dipped asthe gradually. In 70 the reactant, it cools for the additional 3 hoursafter doing the mixing. Bis (3- bromophenyl) methanones (32 g, 93.2 mmol) aredissolved among THF of 200 ml and it dips as the gradually. The reactant isstirred under the reflux for 4 hours. Subsequently, the arrangement is filteredand THF is removed of the Rotavapor. The acetic acid of 400 ml and concentratedhydrochloric acid of 75 ml are added and the water of 200 ml the mixture isadded in 75for 4 hours after doing the mixing. The solid in which the colour is pale isfiltered to the suction and it washes to the methanol. Solid is stirred for1 hour among the boiling ethyl acetate and it filters and it washes to ethanol.The yield is 28.2 g (62percent of the Theoretical value) as the white solid
  • 50
  • [ 25032-74-0 ]
  • [ 7025-06-1 ]
  • C57H42N2O [ No CAS ]
  • 51
  • [ 2052-07-5 ]
  • [ 25032-74-0 ]
  • [ 1211547-22-6 ]
YieldReaction ConditionsOperation in experiment
92% Firstly, magnesiums (6.73 g, 255.8 mmol) areintroduced to the flask including one iodine crystal. 2- bromo biphenyls (64.4g, 276.3 mmol), the anhydrous tetrahydrofuran of 400 ml, the anhydrous tolueneof 500 ml, and 1,2- dimethoxyethane of 45 ml and 1,2- dichloroethane of 2.65 mlare introduced within the dropping funnel. The outbound - material blend isdipped as the gradually. The reactant is cooled under the reflux for theadditional 1 hour after doing the mixing. Bis - (3- bromo-phenyl) methanones(61.4 g, 180.6 mmol) are dissolved among THF of 600 ml and it dips as thegradually. The reactant is stirred under the reflux for 5 hours. Thearrangement is filtered and THF is evaporated in the Rotavapor. The acetic acidof 500 ml, and the acetic acid of 200 ml and HBr of 10 ml are added and themixture is stirred under the reflux for 64 hours. The solid in which the colouris pale is filtered to the suction and it washes to the ethyl acetate andethanol. The yield is 79.8 g (92% of the Theoretical value) as the white solid
91% About 10 ml of a solution of 2-bromobiphenyl (80.0 g, 343 mmol) and 1,2-dibromoethane (3.6 ml, 43 mmol) in a mixture of 640 ml of toluene, 520 mlof tetrahydrofuran and 60 ml of ethylene glycol dimethyl ether are added to8.8 g of magnesium (334 mmol) and heated. After onset of the reaction,the heating is removed and the remaining solution is added dropwise insuch a way that reflux is maintained. On completion of addition, the mixtureis heated to reflux for 1 h. Subsequently, under gentle reflux, a solution ofthe ketone KI (80.0 g, 235 mmol) in 800 ml of tetrahydrofuran is addeddropwise and the mixture is stirred under reflux for 5 h. The heating isremoved and the mixture is stirred for 14 h. The solvents are removedcompletely on a rotary evapourator. The remaining residue is taken up in amixture of 920 ml of glacial acetic acid and 13.2 ml of a 33% solution of hydrogen bromide in acetic acid, and heated to reflux for 6 h. After removing the heating, the mixture is stirred for 16 h. The solid material formed is filtered off with suction, washed with about 150 ml of glacial acetic acid and three times with 250 ml each time of ethanol and then dried in a vacuum drying cabinet. This leaves 101.6 g (213 mmol, 91% of theory)of the product as a light grey solid having a purity of about 99% by 1 HNMR.
82.1% 62.9 g (270 mmol) of 2-bromobiphenyl mixed with 400 ml of THF, 550 ml of toluene, 45 ml of 1,2-dimethoxyethane and 2.6 ml of 1,2-dibromoethane are reacted with 6.6 g (250 mmol) of magnesium to give the corresponding Grignard compound. A solution of 60.0 g (176 mmol) of bis(3-bromophenyl) ketone in 600 ml of THF is added dropwise to the cooled Grignard solution. When the addition is complete, the reaction mixture is heated under reflux for 4 h, the solvent is then removed in vacuo, the residue is dissolved in 700 ml of glacial acetic acid, 10 ml of hydrogen bromide in 30% glacial acetic acid are added, and the mixture is heated under reflux for 6 h. After cooling with stirring, the precipitated solid is filtered off with suction, washed twice with 200 ml of glacial acetic acid each time and three times with 300 ml of ethanol each time and then dried in vacuo. Yield: 69.0 g (145 mmol), 82.1%, 99% pure according to1H-NMR.
  • 52
  • [ 25032-74-0 ]
  • [ 1189114-49-5 ]
  • C40H28Br2O [ No CAS ]
  • 53
  • [ 25032-74-0 ]
  • [ 3508-62-1 ]
  • bis(3-(10,10-diphenyldibenzo[b,e][1,4]azasilin-5(10H)yl)phenyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
35% With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; at 110℃; for 24h; Well-dried 100 mL three-necked round bottom flask charged with bis (3-bromophenyl) methanone (1 g, 2.94 mmol), 10,10-diphenyl-5,10-dihydrodibenzo [b, e] [1,4] azasiline (2.26 g, 6.47 mmol), Na-t-butxide (0.57 g, 5.9mmol), tris (tertbutyl) phosphine (0.06 g, 0.29 mmol) And Pd2(dba)3 (0.13 g, 0.15 mmol) were dissolved in 15 ml of toluene and it was stirred for 24 hours at 110C . After completion of the reaction was poured into water, and extracted three times with chloroform. The extracted organic layer was dried using MgSO4, the solvent was removed using a rotary evaporator, and separated by column chromatography using EA / n-Hexane (1/3) to obtain the compound 2 g (yield = 35%).
  • 54
  • [ 25032-74-0 ]
  • [ 108-36-1 ]
  • tris(3-bromophenyl)methanol [ No CAS ]
  • 55
  • [ 108-36-1 ]
  • [ 105-58-8 ]
  • [ 25032-74-0 ]
  • 56
  • [ 25032-74-0 ]
  • [ 19099-48-0 ]
  • C34H36Br2O [ No CAS ]
  • 57
  • [ 25032-74-0 ]
  • 5-phenyl-5,7-dihydroindolo[2,3-b]carbazole [ No CAS ]
  • C61H38N4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With tris-(dibenzylideneacetone)dipalladium(0); tributylphosphine; sodium t-butanolate; In toluene; for 24h;Inert atmosphere; Reflux; 250ml of four bottles, in the atmosphere of nitrogen,0.01 mol of <strong>[25032-74-0]3,3'-dibromobenzophenone</strong> was added,0.025 mol of intermediate E, 0.03 mol of sodium tert-butoxide,1 x 10-4 mol Pd2 (dba) 3, 1 x 10-4 mol tri-tert-butylphosphine,150 ml of toluene, heated to reflux for 24 hours,Sampling point plate, the reaction is complete.Natural cooling, filtration, the filtrate steamed, silica gel column, the target product, purity 99.1%, yield 69%.
  • 58
  • [ 25032-74-0 ]
  • 7,13-dihydro-13,13-dimethyl-7-phenyl-5H-indole[3,2-b]acridine [ No CAS ]
  • C67H50N4O [ No CAS ]
YieldReaction ConditionsOperation in experiment
72.00% With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Inert atmosphere; Reflux; The specific route of the compound is provided:250ml of four bottles, in the atmosphere of nitrogen,0.01 mol of 2,2'-dibromobenzophenone was added,0.025 mol of 6,6-dimethyl-13-phenyl-11,13-dihydro-6H-11,13-diaza-indole [1,2-b] anthracene,0.03 mol of sodium tert-butoxide,1 x 10-4 mol Pd2 (dba) 3,1 x 10-4 mol tri-tert-butylphosphine,150 ml of toluene, heated to reflux for 24 hours,Sampling point plate, the reaction is complete; natural cooling, filtration, the filtrate steamed, too silicone column,Get the target product,Purity 99.5%Yield 72.00%.Elemental analysis structure (formula C66H49N4O): Theory C, 86.80; H, 5.44; N, 6.04; O, 1.73;Found: C, 86.63; H, 5.29; N, 6.30; O, 1.78.HPLC-MS: molecular weight of 926.40, measured molecular weight 926.52.
  • 59
  • [ 25032-74-0 ]
  • C24H23N [ No CAS ]
  • C61H52N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
66.00% With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Inert atmosphere; Reflux; The specific route of the compound is provided:250ml four bottles,In the atmosphere of nitrogen gas,0.01 mol of 2,2'-dibromobenzophenone was added,0.025 mol of 11,11,13,13-tetramethyl-11,13-dihydro-6H-6-aza-indole [1,2-b]0.03 mol of sodium tert-butoxide,1 x 10-4 mol Pd2 (dba) 3,1 x 10-4 mol tri-tert-butylphosphine,150 ml of toluene,Heated to reflux for 24 hours, the sampling plate, the reaction is complete. Natural cooling, filtration, filtrate steaming, silica gel column,Get the target product,Purity 99.2%, yield 66.00%.Elemental analysis structure (formula C61H54NO): Theory C, 88.16; H, 6.55; N, 3.37; O, 1.93;Test value: C, 88.20; H, 6.62; N, 3.32; O, 1.86.HPLC-MS: molecular weight of 830.42, measured molecular weight 830.62.
  • 60
  • [ 25032-74-0 ]
  • [ 1108157-34-1 ]
  • 1,1-di(3-bromophenyl)-2,2-di(4-hexyloxyphenyl)ethylene [ No CAS ]
  • 61
  • [ 25032-74-0 ]
  • [ 1108157-34-1 ]
  • C76H84O4 [ No CAS ]
  • 62
  • [ 25032-74-0 ]
  • [ 60100-09-6 ]
  • N-(bis(3-bromophenyl)methyl)formamide [ No CAS ]
  • 63
  • [ 25032-74-0 ]
  • [ 78600-31-4 ]
  • C31H21Br2N [ No CAS ]
YieldReaction ConditionsOperation in experiment
68.1% 2.6 g (0.11 mol) of magnesium, 21.3 g (0.066 mol) of the compound represented by the formula (1-a) obtained in the reaction scheme 1 and 600 mL of tetrahydrofuran were placed in a 1 L round bottom flask,The mixture was stirred at room temperature for 1 hour.The compound obtained from [Scheme 3]20.1 g (0.06 mol) of the compound represented by the general formula [1-c] was added to the reaction product rapidly and refluxed for 2 hours. The reaction mixture was cooled to room temperature, and 0.1 molar hydrochloric acid aqueous solution was added thereto. The organic layer was concentrated under reduced pressure, and purified by column chromatography using hexane. To a 1 L round bottom flask, 500 mL of acetic acid and 5 mL of hydrochloric acid were refluxed . After completion of the reaction, the temperature was lowered to room temperature and the crystals were filtered. Recrystallization from methanol was carried out and the product was dried to obtain 25.4 g (68.1percent) of the compound represented by the formula (1-e)
  • 64
  • [ 24398-88-7 ]
  • [ 108-36-1 ]
  • [ 25032-74-0 ]
YieldReaction ConditionsOperation in experiment
49% Under nitrogen, 1,3-dibromobenzene (30.0 g, 127 mmol)Was dissolved in THF (tetrahydrofuran)After dissolving in 300 mL, nBuLi (2.5M) 140 mmol, 56.0 mL was added and stirred at -78 C for 1 hourEthyl-3-bromobenzoate (26.2 g, 114 mmol) is added with a small amount of solvent. After 10 hours, the reaction mixture was slowly warmed to room temperature, quenched with NH4Cl, and extracted with ethyl acetate.The resulting organic solvent layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. This was subjected to column chromatography using ethyl acetate: hexane (EA: Hx) to obtain 21.0 g of [intermediate 1-1] (yield = 49%).
49% 1,3-Dibromobenzene (30.0 g, 127 mmol) was dissolved in 300 mL of THF (tetrahydrofuran) under nitrogen, 140 mmol of nBuLi (2.5 M) (56.0 mL) was added and stirred at -78 C for 1 hour. Ethyl 3-Bromobenzoate (26.2 g, 114 mmol) was added with a small amount of solvent. After 10 hours, the temperature was gradually raised to room temperature, and the residue was extracted with NH4Cl and extracted with ethyl acetate (EA). The resulting organic solvent layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. This was subjected to column chromatography with EA: Hx to obtain 21.0 g (yield = 49%) of [intermediate 1-1].
  • 65
  • [ 25032-74-0 ]
  • C33H25ClN2O2 [ No CAS ]
  • 66
  • [ 25032-74-0 ]
  • C31H21ClN2O [ No CAS ]
  • 67
  • [ 25032-74-0 ]
  • [ 107-07-3 ]
  • C15H12Br2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -40 - 20℃; for 2h;Inert atmosphere; Under nitrogen conditions [intermediate 1-1] (20.0 g, 58.8 mmol)Was dissolved in 150 mL of THF (tetrahydrofuran) / DMF (dimethylformaldehyde)And the reaction temperature was lowered to -40 C. Then, chloroethanol (16.6 ml, 88.2 mmol)Was added KtBuO (20% THF, 82.5 g, 88.2 mmol)Was slowly added dropwise.After 2 hours, the temperature was gradually raised to room temperature, and the mixture was extracted with water and EA. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. This was columned with EA: Hx to obtain 21.0 g (yield 93%) of [Intermediate 1-2].
93% With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -40 - 20℃; for 2h;Inert atmosphere; [Intermediate 1-1] (20.0 g, 58.8 mmol) was dissolved in 150 mL of THF (tetrahydrofuran) / DMF (dimethylformamide) under nitrogen, and the reaction temperature was lowered to -40 C. Then, chloroethanol (16.6 ml, 88.2 mmol) was added and KtBuO (20% THF, 82.5 g, 88.2 mmol) was gradually added dropwise. After 2 hours, the temperature was gradually raised to room temperature, and the mixture was extracted with water and EA. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. This was subjected to column chromatography with EA: Hx to obtain 21.0 g (yield 93%) of [intermediate 1-2].
  • 68
  • [ 25032-74-0 ]
  • [ 654664-63-8 ]
  • C31H19BrO [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 80℃; for 12h;Inert atmosphere; General procedure: Under a nitrogen atmosphere, (27.4g, 60mmol) of compound 5-2-4 and (16.9g, 60mmol) of compound 8-8-1, (4.16g, 3.6mmol ) Tetrakis (triphenylphosphonium) palladium, (2.6g, 8mmol) tetrabutylammonium bromide, (2.4g, 60 mmol) sodium hydroxide, (30mL) water and (200mL) toluene were added to a 350mL three-necked flask, The reaction was stirred and heated at 80 C for 12 hours. The reaction was ended. Most of the solvent was removed by rotary evaporation. The organic solution was washed 3 times with dichloromethane, and the organic liquid was collected and purified by silica gel. The yield was 65%.
  • 69
  • [ 25032-74-0 ]
  • C16H11BN2O2 [ No CAS ]
  • C29H17BrN2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 80℃; for 12h;Inert atmosphere; General procedure: Under a nitrogen atmosphere, (27.4g, 60mmol) of compound 5-2-4 and (16.9g, 60mmol) of compound 8-8-1, (4.16g, 3.6mmol ) Tetrakis (triphenylphosphonium) palladium, (2.6g, 8mmol) tetrabutylammonium bromide, (2.4g, 60 mmol) sodium hydroxide, (30mL) water and (200mL) toluene were added to a 350mL three-necked flask, The reaction was stirred and heated at 80 C for 12 hours. The reaction was ended. Most of the solvent was removed by rotary evaporation. The organic solution was washed 3 times with dichloromethane, and the organic liquid was collected and purified by silica gel. The yield was 65%.
  • 70
  • [ 25032-74-0 ]
  • triphenylen-1-ylboronic acid [ No CAS ]
  • C31H19BrO [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 80℃; for 12h;Inert atmosphere; General procedure: Under a nitrogen atmosphere, (27.4g, 60mmol) of compound 5-2-4 and (16.9g, 60mmol) of compound 8-8-1, (4.16g, 3.6mmol ) Tetrakis (triphenylphosphonium) palladium, (2.6g, 8mmol) tetrabutylammonium bromide, (2.4g, 60 mmol) sodium hydroxide, (30mL) water and (200mL) toluene were added to a 350mL three-necked flask, The reaction was stirred and heated at 80 C for 12 hours. The reaction was ended. Most of the solvent was removed by rotary evaporation. The organic solution was washed 3 times with dichloromethane, and the organic liquid was collected and purified by silica gel. The yield was 65%.
  • 71
  • [ 25032-74-0 ]
  • [ 611-79-0 ]
  • C39H24N2O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
10.6% With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; at 100℃; for 24h; A catalyst consisting of tris(dibenzylideneacetone)-dipalladium(0) (Pd2dba3) (2.747 g, 3 mmol) and tris(tert-butyl)phosphine (18.2 mL, 18 mmol) dissolved in 100 mL toluene and preformed by stirring for 15 min at room temperature was added to bis(3-bromophenyl)methanone (20.4006 g, 60 mmol), <strong>[611-79-0]bis(3-aminophenyl)methanone</strong> (6.3675 g, 30 mmol), and sodium tert-butoxide (17.298 g, 180 mmol) dissolved in 400 mL toluene. This mixture was stirred for 24 h at 100 C and then cooled to room temperature, filtered off, and washed with CH2Cl2. After removing the solvent, the product was purified by chromatography on silica gel with petroleum ether/CH2Cl2 as eluent and recrystallized from tetrahydrofuran/methanol to obtain the desired pure product (yield = 1.81 g, 10.6%). 1H NMR (500 MHz, CDCl3): δ 7.66 (dt, J = 7.6 Hz, 1.3 Hz, 6H), 7.44 (t, J = 7.8 Hz, 6H), 7.37 (ddd, J = 8.0 Hz, 2.1 Hz, 1.1 Hz, 6H), 6.92 (t, J = 1.8 Hz, 6H). 13C NMR (126 MHz, CDCl3): δ 194.94, 148.99, 138.10, 131.04, 130.92, 129.20, 125.70. Anal. calcd (%) for C39H24N2O3: C 82.38, H 4.25, N 4.93; found: C 82.21, H 4.19, N 4.98. APCI-MS (m/z): [M]+ calculated for C39H24N2O3, 568.63; found, 569.5.
  • 74
  • [ 123-75-1 ]
  • [ 25032-74-0 ]
  • C21H24N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110℃;Inert atmosphere; i) Under argon conditions, a mixture of A (2.97 mmol), Pd(OAc)2 (0.45 mmol), BINAP (0.32 mmol), Cs2CO3 (8.62 mmol) and pyrrolidine (1.2 mL) was dissolved in toluene,The reaction was stirred at 110C. The reaction was monitored by TLC until the end of the reaction. After cooling to room temperature, the reaction mixture was washed with water and evaporated. The crude product was purified by silica gel column chromatography (ethyl acetate/hexane = 1/25) to obtain a pale yellow solid B1.
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110℃;Inert atmosphere; Under argon conditions, A (2.97 mmol), Pd(OAc)2 (0.45 mmol),The mixture of BINAP (0.32 mmol), Cs2CO3 (8.62 mmol) and pyrrolidine (1.2 mL) was dissolved in toluene, and the reaction was stirred at 110C.The reaction was monitored by TLC until the end of the reaction. After cooling to room temperature, the reaction mixture was washed with water and evaporated. The crude product was subjected to silica gel column chromatography (ethyl acetate/hexane = 1/25)It was purified to obtain a pale yellow solid B1.
  • 75
  • [ 25032-74-0 ]
  • 1,1,2,2-tetrakis(3-amidinophenyl)ethylene [ No CAS ]
  • 76
  • [ 25032-74-0 ]
  • C30H28N8*2C3H4O4 [ No CAS ]
  • 77
  • [ 25032-74-0 ]
  • C30H28N8*2C6H10O4 [ No CAS ]
  • 78
  • [ 25032-74-0 ]
  • C30H28N8*2C7H12O4 [ No CAS ]
  • 79
  • [ 25032-74-0 ]
  • C30H28N8*2C8H14O4 [ No CAS ]
  • 80
  • [ 25032-74-0 ]
  • C30H28N8*2C8H6O4 [ No CAS ]
  • 81
  • [ 25032-74-0 ]
  • C30H28N8*2C10H10O4 [ No CAS ]
  • 82
  • [ 25032-74-0 ]
  • C30H28N8*2C13H24O4 [ No CAS ]
  • 83
  • [ 25032-74-0 ]
  • 1,1,2,2-tetrakis(3-bromophenyl)ethylene [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With titanium tetrachloride; zinc; In N,N-dimethyl-formamide; at 0℃; for 23h;Inert atmosphere; Reflux; To a mixture of 3,3′-dibromobenzophenone (1.02 g, 2.99 mmol) and zinc powder (442 mg, 6.76 mmol) in dry THF (33 mL) was added TiCl4 (370 μL, 3.37 mmol) during 5 min at 0C under an Ar atmosphere, then stirred for 0.5 h at 0 C. The reaction mixture was stirred at room temperature for 0.5 h, then refluxed for 22 h. After cooling to room temperature, 10% K2CO3 aq. (10 mL) was added, extracted with CH2Cl2 (50 mL x 2), dried over anhydrous Na2SO4 and the solvent was evaporated. 1,1,2,2-Tetrakis(3-bromophenyl)ethylene was isolated (900 mg, 93 %) by column chromatography (SiO2, CHCl3/hexane 1/4). Colorless solid; mp 176.5-177.0 C; 1H NMR (500 MHz, CDCl3) δ=7.30 (m, 4H), 7.13 (t, J=1.8 Hz, 4H), 7.02 (t, J=7.9 Hz, 4H), 6.92 (m, 4H). 13C NMR (125 MHz, CDCl3); δ=144.0 (Cq), 140.1 (Cq), 133.7 (CH), 130.5 (CH), 129.64 (CH), 129.58 (CH), 122.2 (Cq); HRMS (FAB, NBA) m/z=643.7978 (calculated for M+: 643.7986). Anal. Calcd. For C26H16Br4: C:48.19, H:2.49. Found: C:48.11, H:2.52.
  • 84
  • [ 25032-74-0 ]
  • 1,1,2,2-tetrakis(3-cyanophenyl)ethylene [ No CAS ]
  • 85
  • [ 25032-74-0 ]
  • 1,1,2,2-tetrakis(3-amidinophenyl)ethylene tetrahydrochloride [ No CAS ]
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