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Chemical Structure| 860436-54-0 Chemical Structure| 860436-54-0

Structure of 860436-54-0

Chemical Structure| 860436-54-0

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Product Details of [ 860436-54-0 ]

CAS No. :860436-54-0
Formula : C12H18ClNO2
M.W : 243.73
SMILES Code : COC1=C(OC)C=C2C(CNCCC2)=C1.[H]Cl
MDL No. :MFCD31536320
InChI Key :XIMSPHIWFPTHDJ-UHFFFAOYSA-N
Pubchem ID :86061604

Safety of [ 860436-54-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 860436-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 860436-54-0 ]

[ 860436-54-0 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 72584-69-1 ]
  • [ 860436-54-0 ]
YieldReaction ConditionsOperation in experiment
85% The tetrahydro-benzazepinone (1 eq.) was suspended in THF (dry) and the suspension was cooled on an ice bath under nitrogen. A solution of borane in THF (3 eq.) was then added dropwise. The reaction mixture was then refluxed (70 C.) overnight. After, the mixture was cooled on an ice bath and a large excess of MeOH and 5N HCl solution (equal amounts) were added. The solution was heated to 90 C. for two hours. Solvents were then evaporated. Purification was done by re-crystallization of the hydrochloride from a mixture of CH2Cl2 and MeOH. The benzazepinone starting materials and the corresponding benzazepines are listed in Table 2.
  • 2
  • [ 860436-54-0 ]
  • 7,8-dihydroxy-2,3,4,5-tetrahydro-2-benzazepine hydrobromide [ No CAS ]
  • 3
  • [ 2107-70-2 ]
  • [ 860436-54-0 ]
  • 4
  • [ 27798-73-8 ]
  • [ 860436-54-0 ]
  • 5
  • [ 14773-41-2 ]
  • [ 860436-54-0 ]
  • 6
  • [ 14773-42-3 ]
  • [ 860436-54-0 ]
  • 7
  • [ 113193-85-4 ]
  • [ 860436-54-0 ]
  • 8
  • N-acetyl-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine [ No CAS ]
  • [ 860436-54-0 ]
  • 9
  • C17H25NO4 [ No CAS ]
  • [ 860436-54-0 ]
YieldReaction ConditionsOperation in experiment
95% With hydrogenchloride; In dichloromethane; for 3.0h; N-Boc-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine 1.63 g (0.005 mol) was dissolved in methylene chloride and passed through Into hydrogen chloride gas,The reaction was carried out for 3 hours,The filtrate was filtered to obtain 1.15 g of 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine hydrochloride in 95% yield.
 

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