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Chemical Structure| 86225-78-7 Chemical Structure| 86225-78-7

Structure of 86225-78-7

Chemical Structure| 86225-78-7

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Product Details of [ 86225-78-7 ]

CAS No. :86225-78-7
Formula : C9H10N2
M.W : 146.19
SMILES Code : N#CC1=CC=C(C(N)C)C=C1
MDL No. :MFCD09733813

Safety of [ 86225-78-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H315-H318-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 86225-78-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 86225-78-7 ]

[ 86225-78-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 71760-04-8 ]
  • [ 38675-10-4 ]
  • [ 86225-78-7 ]
  • [ 182159-22-4 ]
YieldReaction ConditionsOperation in experiment
With diisopropylamine; In dichloromethane; ethyl acetate; (c) Boc-D-phenylalanyl-proline (D,L)-α-methyl-4-cyanobenzylamide 16.2 g of diisopropylamine and 22 ml (30 mmol) of propanephosphonic anhydride (50% strength solution in ethyl acetate) were added dropwise to a solution of 3.65 g (25 mmol) of 1-(4-cyanophenyl)ethylamine and 9.1 g (25 mmol) of <strong>[38675-10-4]Boc-D-Phe-Pro-OH</strong> in 150 ml of methylene chloride at -50 C. The mixture was stirred for 2 h, during which the temperature was allowed to rise from -5 to 20 C. The organic phase was washed with water, 5% strength sodium bicarbonate and 5% strength citric acid solutions, dried over Na2SO4 and evaporated to dryness. A pale yellowish crystalline residue was obtained and was used without further purification in the next reaction.
  • 2
  • [ 71760-04-8 ]
  • [ 38675-10-4 ]
  • [ 86225-78-7 ]
  • Boc-(D)-phenylalanylproline (α-methyl-4-cyano)benzylamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With diisopropylamine; In dichloromethane; ethyl acetate; (c) Boc-(D)-phenylalanylproline (α-methyl-4-cyano)benzylamide 16.2 g of diisopropylamine and 22 ml (30 mmol) of propanephosphonic anhydride (50% strength solution in ethyl acetate) were added dropwise to a solution of 3.65 g (25 mmol) of 1-(4-cyanophenyl)ethylamine and 9.1 g (25 mmol) of <strong>[38675-10-4]Boc-D-Phe-Pro-OH</strong> in 150 ml of methylene chloride at -5 C. The mixture was then stirred for 2 h, during which the temperature was allowed to rise from -5 to 20 C. The organic phase was washed with water, 5%. strength sodium bicarbonate solution and 5% strength citric acid solution, dried over Na2 SO4 and evaporated to dryness. A pale yellowish crystalline residue was obtained and was used without further purification in the next reaction.
 

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