630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Boronic acids/esters >>1,3,2-DioxaborinaneAliphatic BoronsAromatic BoronsBCATBoric AcidsMIDA BoronatesOther BoronatesOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl ChloridesAlcohols
AldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic LiquidsSolid Supported SynthesisStains and Dyes >>
Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Material OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Heterocyclic Building Blocks
Pyrimidines
Pentyl (5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyrimidines
Amines Fluorinated Building Blocks Amides

[ CAS No. 862508-03-0 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 862508-03-0
Chemical Structure| 862508-03-0
Structure of 862508-03-0 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 862508-03-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 862508-03-0 ]

SDS Specification
Alternatived Products of [ 862508-03-0 ]
Product Citations

Product Details of [ 862508-03-0 ]

CAS No. :862508-03-0 MDL No. :
Formula : C10H14FN3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 243.23 Pubchem ID :-
Synonyms :

Safety of [ 862508-03-0 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 862508-03-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 862508-03-0 ]

[ 862508-03-0 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 37076-71-4 ]
  • [ 862508-03-0 ]
  • [ 162204-20-8 ]
YieldReaction ConditionsOperation in experiment
28%
Stage #1: Inert atmosphere
Stage #2: With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 20℃; for 0.5 h;
Stage #3: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -78 - 20℃; 		2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(n-pentyloxycarbonyl)cytidine (11) A solution of 1,2,3-tri-O-acetyl-5-deoxy-D- ribofuranoside (107 mg, 0,41 mmol) in anhydrous acetonitrile (3 mL) was treated with N4-(n-pentyloxycarbonyl)-5-fluorocytosine (100 mg, 0,41 mmol) under an argon atmosphere. The resulting suspension was treated with hexamethyldisilazane anhydrous (87 μL, 0,41 mmol) and chlorotrimethylsilane (210 μL, 1,64 mmol). It was stirred at ambient temperature for 30 minutes. The reaction mixture was cooled at -78°C and trimethylsilyl triflate (87 μL, 0,49 mmol) was added. It was taken one more time to ambient temperature and it was stirred for 5 hours. It was diluted with dichloromethane (50 mL) and it was washed with water (2 x 20 mL). The organic phase was dried (Na2SO4) and the solvent was evaporated. The product was purified by means of column chromatography (silica gel). A mixture of hexane-ethyl acetate (4:1) was used as elution which gave 51 mg (28percent yield) of the desired product as a colorless oil. 1H RMN (CDCl3, 500 MHz) δ 0.91 (t, J = 7.1 Hz, 3H, H-5"), 1.36 (m, 4H, H-3", H-4"), 1.47 (d, J = 6.5 Hz, 3H, H-5'), 1.71 (p, J = 7.0 Hz, 2H, H-2"), 2.10 (s, 3H, COCH3), 2.11 (s, 3H, COCH3), 4.17 (t, J = 5.6 Hz, 2H, H-1 "), 5.01 (t, J = 5.5 Hz, 1H, H-), 5.30 (t, J = 5.4 Hz, 1H, H-) 5.95 (d, J = 4.2 Hz, 1H, H-1'), 7.42 (s, 1H, ), 12.01 (s, 1H); 13C RMN (CDCl3, 125 MHz) δ13.85, 18.60 (C-5'), 20.32 (COCH3), 20.43 (COCH3), 22.23 (C-4"), 27.85 (C-3"), 28.17 (C-2"), 66.59 (C-1"), 72.91, 73.88, 78.20, 87.96, 123.38, 123.65, 138.93, 146.18, 153.09, 153.25, 163.44, 169.56 (COCH3), 169.63 (COCH3).
Reference： [1] Patent: EP2241556, 2010, A1, . Location in patent: Page/Page column 9
  • 2
  • [ 37076-71-4 ]
  • [ 862508-03-0 ]
  • [ 162204-20-8 ]
YieldReaction ConditionsOperation in experiment
330.8 g at 5 - 40℃; for 3 h; (2) adding 201.6 g of 1,2,3-tri-O-acetyl-5-deoxy-6-ribofuranose to 1 of the step (1), 184g of boron trifluoride etherate was added dropwise at a temperature of 5 ° C to 10 ° C.complete, Warming up to 35 ° C -40 ° C for 3 h, then drip it back into 413.3g of sodium bicarbonate mixed with 153.3g of water, Stir the reaction for 2 h, The organic layer was dried by suction and concentrated. Use concentrate 50g methanol and 200g water mixture crystallization for 2h, suction filtration, drying to obtain capecitabine intermediate 2',3'-O-Diacetyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine 330.8 g, total molar yield 96.3percent, product purity 99.65percent. Hydrogen The spectral data is the same as in the first embodiment.
Reference： [1] Patent: CN104926901, 2018, B, . Location in patent: Paragraph 0033; 0035; 0036; 0038; 0039; 0041

Tags: 862508-03-0 synthesis path| 862508-03-0 SDS| 862508-03-0 COA| 862508-03-0 purity| 862508-03-0 application| 862508-03-0 NMR| 862508-03-0 COA| 862508-03-0 structure

Recommend Products
Same Skeleton Products
Related Products
Isomers
Categories
Chemistry
Heterocyclic Building Blocks
Pyrimidines
Chemistry
Organic Building Blocks
Amides
Chemistry
Organic Building Blocks
Amines
Chemistry
Organic Building Blocks
Fluorinated Building Blocks

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction
Historical Records
; ;