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Chemical Structure| 864244-74-6 Chemical Structure| 864244-74-6

Structure of 864244-74-6

Chemical Structure| 864244-74-6

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Product Details of [ 864244-74-6 ]

CAS No. :864244-74-6
Formula : C11H10FN3O
M.W : 219.22
SMILES Code : NC1=NC=CC(OC2=CC=C(C=C2F)N)=C1
MDL No. :MFCD24624321

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Application In Synthesis of [ 864244-74-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 864244-74-6 ]

[ 864244-74-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38116-61-9 ]
  • [ 864244-74-6 ]
  • N-(4-(2-aminopyridin-4-yloxy)-3-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide, trifluoroacetic acid salt [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20℃; for 72h; To a solution of <strong>[38116-61-9]2-hydroxy-6-methylnicotinic acid</strong> (Lancaster, 72 mg, 0.47 mmol) and HOBt (50 mg) in DMF (5 mL) at rt was added EDCI.HCl (130 mg, 0.68 mmol) followed by 4-(4-amino-2-fluorophenoxy)pyridine-2-amine (Compound B of Example 24, 110 mg, 0.50 mmol), and the reaction mixture was stirred at rt over 72 h. Purification of the reaction mixture by preparative HPLC afforded the desired product (125 mg, 55%) as a beige-colored solid (TFA salt). 1H NMR (CD3OD) delta 8.46 (d, 1H, J=7.9 Hz), 8.03 (dd, 1H, J=12.7, 2.8 Hz), 7.83 (d, 1H, J=7.1 Hz), 7.44 (dd, 1H, J=8.8, 2.2 Hz), 7.33 (t, 1H, J=8.8 Hz), 6.67 (dd, 1H, J=7.7, 2.7 Hz), 6.45 (d, 1H, J=7.7 Hz), 6.21 (d, 1H, J=2.8 Hz), 2.40 (s, 3H); MS (ESI+) m/z 355.2 (M+H)+.
 

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