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Chemical Structure| 864685-25-6 Chemical Structure| 864685-25-6

Structure of 864685-25-6

Chemical Structure| 864685-25-6

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Product Details of [ 864685-25-6 ]

CAS No. :864685-25-6
Formula : C10H12ClNS
M.W : 213.73
SMILES Code : ClC1=CC(C2NCCSC2)=CC=C1
MDL No. :MFCD06657776

Safety of [ 864685-25-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 864685-25-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 864685-25-6 ]

[ 864685-25-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 860625-20-3 ]
  • [ 864685-25-6 ]
  • 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-(3-thiomorpholinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
11% With potassium carbonate;tetrakis(triphenylphosphine)palladium (0); In 1,4-dioxane; dichloromethane; water; Example 297 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-(3-thiomorpholinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate To a solution of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide (60 mg, 0.13 mmol) in dioxane (1.5 mL) and water (0.5 mL) was added <strong>[864685-25-6]3-(3-chlorophenyl)thiomorpholine</strong> (84 mg, 0.39 mmol) and potassium carbonate (107.6 mg, 0.78 mmol). This mixture was degassed for 5 min then tetrakis(triphenylphosphine)palladium(0) (14.0 mg, 0.013 mmol) was added. The resulting mixture was reacted in a microwave for 30 min at 160 C. The solid was filtered off and all solvents were evaporated. The resulting solution was re-dissolved in dichloromethane and separator was used to remove water. The mixture was concentrated to give organic solvent and then purified by Gilson Preparatory HPLC to give 7.4 mg of the title compound (11%). LC/MS=m/z 513.4 [M+H] Ret. Time: 1.54
  • 2
  • [ 860625-20-3 ]
  • [ 864685-25-6 ]
  • [ 76-05-1 ]
  • 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-(3-thiomorpholinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
11% Example 297: 3-ri-fethylsulfonyl)-4-piperidinv?-5-r3-(3-thiomorphoiinyl)phenv?-1 H- indole-7-carboxamide trifluoroacetate; To a solution of 3-[1 -(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1 H-indole-7-carboxamide (60 mg, 0.13 mmol) in dioxane (1.5 mL) and water (0.5 mL) was added <strong>[864685-25-6]3-(3-chlorophenyl)thiomorpholine</strong> (84 mg, 0.39 mmol) and potassium carbonate (107.6 mg, 0.78 mmol). This mixture was degassed for 5 min then tetrakis(triphenylphosphine)palladium(0) (14.0 mg, 0.013 mmol) was added. The resulting mixture was reacted in a microwave for 30 min at 160 C. The solid was filtered off and all solvents were evaporated. The resulting solution was re-dissolved in dichloromethane and separator was used to remove water. The mixture was concentrated to give organic solvent and then purified by Gilson Preparatory HPLC to give 7.4 mg of the title compound (11 %). LC/MS = m/z 513.4 [M+H] Ret. Time: 1.54
 

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