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Chemical Structure| 866751-49-7 Chemical Structure| 866751-49-7

Structure of 866751-49-7

Chemical Structure| 866751-49-7

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Product Details of [ 866751-49-7 ]

CAS No. :866751-49-7
Formula : C8H13N3
M.W : 151.21
SMILES Code : NCC1=NC(C)=C(C)N=C1C
MDL No. :MFCD17018339

Safety of [ 866751-49-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3259
Packing Group:

Application In Synthesis of [ 866751-49-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 866751-49-7 ]

[ 866751-49-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 866751-49-7 ]
  • [ 1570-05-4 ]
  • C15H17N3O3 [ No CAS ]
  • 2
  • [ 866751-49-7 ]
  • [ 1570-05-4 ]
  • C29H29N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
91.6% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 12h; Round-bottomed flask were added sequentially 440.88mg (1.32mmol) 16b, 4.30mL (1.33mmol) TMP-NH2The CH2Cl2Solution, 253mg (1.32mmol) EDCI and 59mg (0.44mmol) HOBT; then add 20mL dichloromethane at room temperature the reaction was stirred 12h.TLC [V (petroleum ether) :V (acetone) = 2] Detection reaction is essentially complete, the reaction was successively washed with water (2 × 20mL) and saturated brine (20 mL) wash, dried over anhydrous sodium sulfate, filtered, and reduced pressure evaporated to dryness.The residue was separated by silica gel column to give a white solid, yield: 91.6%,
  • 3
  • [ 866751-49-7 ]
  • [ 23028-17-3 ]
  • C17H21N3O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20℃; for 18.0h; Danshensu 1.0 g (5.0 mmol) was dissolved in 15 mL of DMF, and EDC · HC1 1(6. Ommol) and1-hydroxy-benzo-triazole (HOBt)0.8g (6. Ommol),Stir at room temperature,The reaction system was cooled to 0 C with an ice-water bath,0.83 g of 2-aminomethyl-3,5,6-trimethylpyrazine prepared in Example 1 was added dropwise(5.5 mmol),Reaction at room temperature for 18h,The reaction was monitored by TLC. After the reaction of the starting material was completed, ice-salt water was added to the reaction system(8 wt% NaCl, -4 C, same below) and ethyl acetate and extracted three times with ethyl acetate. The combined ethyl acetate layers were washed with ice-brineWashed three times, washed the organic phase of DMF, the organic phase was dried over anhydrous Na2S04, concentrated under reduced pressure, silica gel column separation (petroleum ether: Ethyl acetate = 1: 3, v / v) to give 1.08 g of pale yellow viscous product as D001 in 65% yield.
 

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[ 866751-49-7 ]

Chemical Structure| 2828433-66-3

A1495735 [2828433-66-3]

tert-Butyl 2-((3,5,6-trimethylpyrazin-2-yl)methyl)hydrazine-1-carboxylate

Reason: Derivatives