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Chemical Structure| 869583-76-6 Chemical Structure| 869583-76-6

Structure of 869583-76-6

Chemical Structure| 869583-76-6

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Product Details of [ 869583-76-6 ]

CAS No. :869583-76-6
Formula : C14H12N2O
M.W : 224.26
SMILES Code : COC1=CN2C(C=C1)=NC(C3=CC=CC=C3)=C2
MDL No. :MFCD19440916

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 869583-76-6 ]

[ 869583-76-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100-41-4 ]
  • [ 10167-97-2 ]
  • [ 869583-76-6 ]
YieldReaction ConditionsOperation in experiment
80% General procedure: Synthesis of 3a is representative. To a solution of ethylbenzene (1a, 1 mmol, 107 mg) in ethylacetate:water (5:1, 6 mL) were added NBS (3.5 mmol, 628 mg) and AIBN (0.1 mmol, 16.5 mg) at roomtemperature, and the mixture was stirred at 65 C for 1.5 h. The mixture was concentrated to drynessand then dissolved in water (5 mL), followed by reaction with 2-aminopyridine (2a, 1.2 mmol, 114 mg)and sodium carbonate (5 mmol, 534 mg) for 2 h at 80 C. After completion of the reaction (as indicatedby TLC), the crude product was extracted with ethyl acetate (3 x 10 mL). The combined organic layerwas dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product was purified bysilica gel column chromatography (PE/EA = 8/1-4/1, v/v) to give 3a (78% yield) as a white solid.
 

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