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Chemical Structure| 869725-56-4 Chemical Structure| 869725-56-4

Structure of 869725-56-4

Chemical Structure| 869725-56-4

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Product Details of [ 869725-56-4 ]

CAS No. :869725-56-4
Formula : C10H8BrF3O2
M.W : 297.07
SMILES Code : O=C(O)CCC1=CC(C(F)(F)F)=CC=C1Br
MDL No. :MFCD09839597

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Application In Synthesis of [ 869725-56-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 869725-56-4 ]

[ 869725-56-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 869725-56-4 ]
  • [ 150969-56-5 ]
YieldReaction ConditionsOperation in experiment
37% With n-butyllithium; In tetrahydrofuran; hexane; at -78℃; Step E 5-(Trifluoromethyl)indan-1-one To a solution of 3-[2-bromo-5-(trifluoromethyl)phenyl]propanoic acid (2.8 g, 9.4 mmol) in THF (100 mL) and hexane (20 mL) at -78 C. was dropwise added a 2.5 M solution of n-butyllithium in hexane (8.3 mL). After the addition had been completed, the reaction was quenched with saturated NH4Cl. The resulting solution was extracted with ethyl acetate twice. The extracts were washed with saturated NaHCO3, brine, dried over MgSO4 and concentrated. The crude material was purified by flash chromatography on silica eluding with 10-20% EtOAc/hexane to afford the desired product as a white solid (0.7 g, 37%). LC/MS calculated for C10H7F3O: (M+H)+ 201; found, 201.1.
  • 2
  • [ 869725-56-4 ]
  • [ 869725-57-5 ]
  • 3
  • [ 1483-55-2 ]
  • [ 869725-56-4 ]
 

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