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Chemical Structure| 87005-17-2 Chemical Structure| 87005-17-2

Structure of 87005-17-2

Chemical Structure| 87005-17-2

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Product Details of [ 87005-17-2 ]

CAS No. :87005-17-2
Formula : C5H6N2O2
M.W : 126.11
SMILES Code : CC(C1=CN=C(N)O1)=O
MDL No. :MFCD09909737

Safety of [ 87005-17-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 87005-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 87005-17-2 ]

[ 87005-17-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 87005-17-2 ]
  • [ 53308-95-5 ]
  • [ 866146-79-4 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20℃; A) tert-butyl (S)-1-(5-acetyloxazol-2-ylcarbamoyl)butylcarbamate To a mixture of 1-(2-aminooxazol-5-yl)ethanone (5 g 39.7 mmol), t-Boc-norvaline (8.6 g, 39.7 mmol), 1-hydroxy-benzotriazole (HOBt) (5.6 g, 41.7 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDAC) (9.1 g, 47.6 mmol) in 600 mL methylene chloride and 85 mL of DMF was added triethylamine (22.1 mL, 158.7 mmol). The mixture was stirred at rt until most of starting material consumed. The mixture was quenched with water and extracted with methylene chloride. The organic layer was washed with dilute HCl, separated, dried and filtered. The filtrate was concentrated to dryness and the residue was purified by silica gel column chromatography using 5-65percent ethyl acetate in hexane as eluent to give the title compound as a brown oil, LC-MS RT=1.5 min, M+1=326. 1H NMR (CD3OD) d 7.89(s, 1H), 4.2 (m, 1H), 2.4(s, 3H0, 1.6-1.8(m, 2H), 1.3-1.5(m, 2H), 1.4(s, 9H), 0.95(t, 3H) ppm.
 

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