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Chemical Structure| 870703-61-0 Chemical Structure| 870703-61-0

Structure of 870703-61-0

Chemical Structure| 870703-61-0

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Product Details of [ 870703-61-0 ]

CAS No. :870703-61-0
Formula : C15H21BrN2O4
M.W : 373.24
SMILES Code : O=C(OC(C)(C)C)N(C1=NC(Br)=CC=C1)C(OC(C)(C)C)=O
MDL No. :MFCD07784371

Safety of [ 870703-61-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335-H413
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 870703-61-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 870703-61-0 ]

[ 870703-61-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 870703-61-0 ]
  • [ 1262035-61-9 ]
  • [ 1262044-15-4 ]
  • [ 1262044-16-5 ]
YieldReaction ConditionsOperation in experiment
A. Preparation of N-6-(1-cyclopropyl-1H-imidazol-5-yl)pyridin-2-yl)-4-(quinolin-3-yl)picolinamide Steps 1 and 2: To a stirred solution of <strong>[1262035-61-9]5-bromo-1-cyclopropyl-1H-imidazole</strong> (780 mg, 1.90 mmol), in tetrahydrofuran (3 mL) at -78 C. was added n-butyllithium (911 muL 2.5 M solution, 2.28 mmol) and the reaction mixture was stirred for 30 minutes at -78 C. A solution of zinc bromide (ZnBr2, (641 mg, 2.85 mmol, dried under vacuum at 100 C. for 3 hours) in tetrahydrofuran (3 mL) was added, the mixture warmed to room temperature and stirred an additional 2.5 hours. A solution of 6-(di-Boc-amino)-2-bromopyridine and Pd(PPh3)4 in 3 mL tetrahydrofuran was added to the reaction via cannula and the mixture was stirred overnight. The reaction was concentrated under reduced pressure and the residue was purified by flash chromatography (5% methanol in methylene chloride, gradient flash: 4%?10% methanol in methylene chloride). The product was isolated as mixture of the mono- and bis-Boc protected 6-(1-cyclopropyl-1H-imidazol-5-yl)pyridin-2-amine. This mixture was used directly in the next step
 

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