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Chemical Structure| 871240-11-8 Chemical Structure| 871240-11-8

Structure of 871240-11-8

Chemical Structure| 871240-11-8

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Product Details of [ 871240-11-8 ]

CAS No. :871240-11-8
Formula : C11H8F3N3O
M.W : 255.20
SMILES Code : NC1=CC=C(OC2=NC(C(F)(F)F)=NC=C2)C=C1
MDL No. :MFCD09864893

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Application In Synthesis of [ 871240-11-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 871240-11-8 ]

[ 871240-11-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 871240-11-8 ]
  • [ 36314-97-3 ]
  • 6-phenyl-N4-(4-[2-(trifluoromethyl)pyrimidin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% 4-[2-(trifluoromethyl)pyrimidin-4-yl]oxy}aniline (1.0 g, 3.9 mmol) and 4-chloro-6- phenylpyrimidin-2-amine (806 mg, 3.9 mol) were suspended in water (39 mL) and isopropanol (13 mL) and the mixture was heated at 95 0C for 17 h. After cooling to rt, the mixture was neutralized with 1 N aqueous sodium hydroxide and stirred for 20 min. The precipitate were collected by filtration to afford 6-phenyl-N4-(4-[2- (trifluoromethyl)pyrimidm-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (1.2 g, 72%) as a yellow solid. 1H NMR (DMSO-J6) delta 9.35 (s, IH), 8.85 (d, IH), 7.85-7.91 (m, 4H), 7.42- EPO <DP n="91"/>7.47 (m, 3H), 7.30 (d, IH), 7.18 (d, 2H), 6.48 (s, IH), 6.38 (brs, 2H); MS ES 425 (M+H)+, calcd 425, RT = 2.53 min.
 

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