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Chemical Structure| 871700-18-4 Chemical Structure| 871700-18-4

Structure of 871700-18-4

Chemical Structure| 871700-18-4

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Product Details of [ 871700-18-4 ]

CAS No. :871700-18-4
Formula : C10H10FIN2O
M.W : 320.10
SMILES Code : O=C(NC1=CC=C(I)C=C1F)NC2CC2
MDL No. :MFCD18207182

Safety of [ 871700-18-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 871700-18-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 871700-18-4 ]

[ 871700-18-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 871700-18-4 ]
  • ethyl 1,5-dimethyl-2,4,6-pyridin-3-carboxylate [ No CAS ]
  • [ 871700-24-2 ]
YieldReaction ConditionsOperation in experiment
14.5 g With sodium ethanolate; In tetrahydrofuran; at 0 - 60℃; for 8.0h; S2: N-(2-Fluoro-4-iodophenyl)-N'-cyclopropyl urea (20.8 g, 65.0 mmol)In a solution of THF (300 mL),Sodium ethoxide (12.2 g, 179.3 mmol) was added portionwise at 0 C and allowed to warm to room temperature.The crude solution of 1,5-dimethyl-2,4,6-pyridinetrione-3-carboxylate prepared in the step S1 was dissolved in THF (200 mL), and reacted at 60 C for 8 h, and cooled to room temperature.Concentrated hydrochloric acid to adjust the pH to 2-3, concentrated to give a viscous solid,Dichloromethane (300 mL) was added and washed with water (50 mL once, three times in total).Dry, concentrated,The residue was recrystallized from acetone to give 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione (14.5 g),Yield 47.3%
 

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