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Chemical Structure| 872366-63-7 Chemical Structure| 872366-63-7

Structure of 872366-63-7

Chemical Structure| 872366-63-7

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Product Details of [ 872366-63-7 ]

CAS No. :872366-63-7
Formula : C7H4FNO3
M.W : 169.11
SMILES Code : O=CC1=CC=CC(F)=C1[N+]([O-])=O
MDL No. :MFCD11111001
InChI Key :RJXDOIOYJGQGQH-UHFFFAOYSA-N
Pubchem ID :22465321

Safety of [ 872366-63-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340

Application In Synthesis of [ 872366-63-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 872366-63-7 ]

[ 872366-63-7 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 872366-63-7 ]
  • [ 1584150-13-9 ]
  • 2
  • [ 872366-63-7 ]
  • [ 1214352-95-0 ]
YieldReaction ConditionsOperation in experiment
89% With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20℃; for 1.08333h; To a cold solution of <strong>[872366-63-7]3-fluoro-2-nitrobenzaldehyde</strong> (3.0 g, 17.74 mmol) inanhydrous CH2Cb (90 mL) was slowly added ( diethylamino )sulfur trifluoride ( 5.15 mL,39 mmol) over 5 min. The resulting solution was removed from the cooling bath and15 allowed to stir at room temperature for 1 hr. The reaction mixture was cooled to -78 ocand poured into a rapidly stirred mixture of ice (450 mL) and saturated aqueous sodiumbicarbonate solution (250 mL). The resulting two phase mixture was diluted withdichloromethane ( 400 mL) and the organic layer was separated. The aqueous layer wasback extracted with dichloromethane (250 mL), the organic layers are combined, washed20 with water (1 x 75 mL), brine (1 x 75 mL), dried over sodium sulfate, filtered andevaporated to dryness. The resulting crude product was purified by silica gelchromatography (BIOTAGE SP1 instrument on a 40g Thomson SINGLE STEPSilica cartridge using a hexane/dichloromethane gradient) to give Intermediate B-5A (3.0g, 89%) as a yellow oil: 1H NMR (500MHz, chloroform-d) 8 7.73-7.64 (m, 1H), 7.59 (dd,25 J=7.9, 0.5 Hz, 1H), 7.46 (t, J=8.9 Hz, 1H), 7.01 (t, J=55.2 Hz, 1H).
  • 3
  • [ 872366-63-7 ]
  • [ 1584150-14-0 ]
  • 4
  • [ 872366-63-7 ]
  • [ 1584150-15-1 ]
  • 5
  • [ 2142-69-0 ]
  • [ 872366-63-7 ]
  • C15H9BrFNO3 [ No CAS ]
  • 6
  • [ 872366-63-7 ]
  • (S)-8'-fluoro-2,3-dimethyl-1'H-spiro[indene-1,2'-quinoline] [ No CAS ]
  • 7
  • [ 872366-63-7 ]
  • 2-(2-bromophenyl)-8-fluoroquinoline [ No CAS ]
 

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