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Chemical Structure| 873194-12-8 Chemical Structure| 873194-12-8

Structure of 873194-12-8

Chemical Structure| 873194-12-8

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Product Details of [ 873194-12-8 ]

CAS No. :873194-12-8
Formula : C15H11F3O2
M.W : 280.24
SMILES Code : O=CC1=CC=C(C(F)(F)F)C=C1OCC2=CC=CC=C2
MDL No. :MFCD26395940

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Application In Synthesis of [ 873194-12-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 873194-12-8 ]

[ 873194-12-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 873194-12-8 ]
  • [ 62327-21-3 ]
  • [ 873194-13-9 ]
YieldReaction ConditionsOperation in experiment
Sodium hydride (60percent wt. disp. oil, 0.406g) was added to a solution of tert-butyl-P,P-dimethylphosphonoacetate (2.27g) in dry DMF (20ml) at 0°C. The mixture was stirred at RTfor 30min, cooled to 0°C, then the product from step (iii) (2.83g) added. After 16h themixture was partitioned between diethylether and water, the organic layer dried, and thesolvent evaporated under reduced pressure. The residue was purified by chromatography onsilica eluting with isohexane/diethylether 4:1, yield 3.25g.1H NMR CDC13: 5 7.98-7.93 (1H, d), 7.63-7.18 (8H, m), 6.52-6.46 (1H, d), 5.18 (2H, s), 1.52(9H, s).
 

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