[ CAS No. 873443-66-4 ] {[proInfo.proName]}

Name: 873443-66-4|2,6-Dichloro-4-(o-tolyl)nicotinonitrile|97%
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Quality Control of [ 873443-66-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 873443-66-4 ]

SDS Specification

Alternatived Products of [ 873443-66-4 ]

Product Details of [ 873443-66-4 ]

CAS No. :	873443-66-4	MDL No. :	MFCD18258872
Formula :	C₁₃H₈Cl₂N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HDFNZYMPHSNNQC-UHFFFAOYSA-N
M.W :	263.12	Pubchem ID :	57355004
Synonyms :

Calculated chemistry of [ 873443-66-4 ]

Physicochemical Properties

Num. heavy atoms :	17
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.08
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	69.37
TPSA :	36.68 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.72 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.52
Log Po/w (XLOGP3) :	4.48
Log Po/w (WLOGP) :	4.24
Log Po/w (MLOGP) :	2.73
Log Po/w (SILICOS-IT) :	4.7
Consensus Log Po/w :	3.73

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-4.75
Solubility :	0.00468 mg/ml ; 0.0000178 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.97
Solubility :	0.00282 mg/ml ; 0.0000107 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-6.25
Solubility :	0.000148 mg/ml ; 0.000000562 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.27

Safety of [ 873443-66-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 873443-66-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 873443-66-4 ]
Downstream synthetic route of [ 873443-66-4 ]

[ 873443-66-4 ] Synthesis Path-Upstream 1~4

1
[ 873443-66-4 ]
[ 342417-01-0 ]

Reference： [1] Organic Process Research and Development, 2006, vol. 10, # 6, p. 1157 - 1166

2
[ 873443-64-2 ]
[ 873443-66-4 ]

Yield	Reaction Conditions	Operation in experiment
83.3%	at 135℃; for 10 h; Heating in Parr bottle	Example 9; This example illustrates a process for preparing 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine (Fig. VIII, Scheme I) A mixture of 40.00 g (131.0 mmol) of the appropriate pyridinium zwitter ion (prepared according to Example 5, 6 or 7) and 50.0 mL (82.3 g, 536 mmol) of phosphorus oxychloride was heated in a 300-mL Parr bottle at 135° C. for 10 hours. The reaction mixture was cooled to 25° C. and diluted with 75 mL of methylene chloride. The solution was transferred onto 350 g of ice. Additional methylene chloride (25 mL) was used to aid the transfer. The resulting mixture was stirred for 1 hour. The layers were separated, and the aqueous layer was extracted twice with 25 mL of methylene chloride and twice with 50 mL of toluene. The extracts were combined, dried (5.0 g Na₂SO₄), and filtered through 15 g of Filtrol.(R). on a 60-mL coarse sintered glass funnel. The flask and the solid were washed with 50 mL of toluene. The combined mother liquors were concentrated to afford 28.70 g (83.3percent) of 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine as a near colorless solid (LC assay 100.7 wt percent). An analytical sample was prepared by recrystallization from isopropanol and revealed: m.p. 129-131° C.; ¹H NMR (CDCl₃) δ 7.43 (dt, J=1.5 Hz, J=7 Hz, 1H), 7.37-7.31 (m, 2 H), 7.33 (s, 1H), 7.18 (dd, J=1.5 Hz, 8 Hz, 1H), 2.25 (s, 3H); ¹³C NMR (CDCl₃) δ 159.1, 153.9, 153.3, 135.3, 134.1, 131.3, 130.7, 128.8, 126.7, 124.5, 113.7, 110.3, 20.0; IR (KBr) 3087, 2227, 1603, 1569, 1520, 1340 cm^-1. Analytically calculated for C₁₃H₈C1₂N₂: C, 59.34; H, 3.06; N, 10.65; Cl, 26.95. Found: C, 59.00; H, 3.05; N, 10.64; Cl, 27.76.

Reference： [1] Patent: US2006/14959, 2006, A1, . Location in patent: Page/Page column 12

3
[ 529-20-4 ]
[ 873443-66-4 ]

Reference： [1] Organic Process Research and Development, 2006, vol. 10, # 6, p. 1157 - 1166

4
[ 70625-63-7 ]
[ 873443-66-4 ]

Reference： [1] Organic Process Research and Development, 2006, vol. 10, # 6, p. 1157 - 1166

[ 873443-66-4 ] Synthesis Path-Downstream 1~21

1
[ 110-91-8 ]
[ 873443-66-4 ]
[ 873443-68-6 ]

Yield	Reaction Conditions	Operation in experiment
78.4%	In methanol; at 18 - 25℃; for 18.75h;	Example 11 This example illustrates a process for preparing 2-chloro-3-cyano-4-(2-methylphenyl) -6-(4-morpholinyl)pyridine (FIG. VIII, Scheme I) The crude dichloride, <strong>[873443-66-4]3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine</strong>, (194.8 g, 0.740 mol, see Example 8) and 1100 mL of methanol were added to a 2000-mL, 3-necked flask (equipped with a 125-mL pressure-equilibrating addition funnel/dry N2 adapter, septum with teflon-coated thermocouple, and teflon paddle stirrer/glass shaft). The mixture was cooled to 18 C. Morpholine (132.3 mL, 132.2 g, 1.52 mol) was charged to the addition funnel and added dropwise to the reaction mixture over a period of 45 minutes. The resulting mixture was stirred at 20-25 C. for 18 hours. The precipitate was filtered, washed successively with 150 mL of methanol and 1000 mL of water, and dried to afford 182.04 g (78.4%) of 2-chloro-3-cyano-4-(2-methylphenyl) -6-(4-morpholinyl)pyridine as a colorless solid. An analytical sample was prepared by recrystallization from isopropanol and revealed: m.p. 152-154 C.; 1H NMR (CDCl3) δ7.35 (dt, J=1.5 Hz, J=7.5 Hz, 1H), 7.31-7.28 (m, 1H), 7.26 (dd, J=1.5 Hz, J=7.5 Hz, 1H), 6.37 (s, IH), 3.81-3.79 (m, 4H), 3.68-3.66 (m, 4H), 2.25 (s, 3H); 13C NMR (CDCl3) δ158.3, 156.9, 153.0, 136.4, 135.1, 130.6, 129.5, 128.4, 126.1, 115.8, 104.7, 97.8, 66.4. 44.8, 19.7; IR (KBr) 2966-2843, 2216, 1597, 1490 cm-1. Analytically calculated for C17Hl6CIN3O: C, 65.07; H, 5.14; N, 13.39; Cl, 11.30. Found: C, 65.38; H, 5.28; N, 13.36; Cl, 11.65.

Reference： [1]Patent: US2006/14959,2006,A1 .Location in patent: Page/Page column 12

2
[ 109-01-3 ]
[ 873443-66-4 ]
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76.6%	In methanol; at 18 - 25℃; for 18.25h;	Example 12; This example illustrate a process for preparing 2-chloro-3-cyano-4-(2-methylphenyl) -6-(4-methylpiperazinyl)pyridine (FIG. IX, Scheme I). Crude dichloride, <strong>[873443-66-4]3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine</strong>, (78.00 g, 0.296 mol) and 330 mL of methanol were added to a 1000-mL, 3-necked flask (equipped with a 125 mL pressure-equilibrating addition funnel/dry N2 adapter, septum with teflon-coated thermocouple, and teflon paddle stirrer/glass shaft), and the mixture was cooled to 18 C. 1-Methylpiperazine (67.3 mL, 60.78 g,0.607 mol) was charged to the addition funnel and added dropwise to the reaction mixture at 18-22 C. over a period of 15 minutes. Seed crystals of 2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine were added after 2 hours and the suspension was stirred at 20-25 C. for an additional 18 hours. Water (165 mL) was added dropwise over 1 hour and the resulting mixture was stirred at 25 C. for 3 hours. The precipitate was filtered, washed successively with 90 mL of 2:1 methanol-H20 and 100 mL of water, and dried to afford 74.19 g (76.6%) of 2-chloro -3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine as a beige solid. An analytical sample was prepared by recrystallization from isopropanol and revealed: m.p. 116-123 C.; 1H NMR (CDCl3) δ7.34 (dt, J=7.5 Hz, J=1.5 Hz, IH), 7.3-7.25 (m, 2H), 7.14 (dd, J=7.5 Hz, J=1.5 Hz, 1H), 6.37 (s, IH), 3.71 (br m, 4H), 2.49 (br t, 4H), 2.35 (s, 3H), 2.25 (s, 3H); 13C NMR (CDC13) 6 158.4, 156.9, 153.2, 136.8, 135.4, 130.9, 129.6, 128.7, 126.3, 116.2, 105.0, 97.3, 54.7, 46.3, 44.8, 20.0; IR (KBr) 2966, 2936, 2846, 2797, 2215, 1592, 1498 cm31 1.Analytically calculated for C18H,gCIN4: C, 66.15; H, 5.86; N, 17.14; Cl, 10.85. Found: C, 66.04; H, 6.04; N, 17.11; Cl, 10.94.

Reference： [1]Patent: US2006/14959,2006,A1 .Location in patent: Page/Page column 12-13

3
[ 873443-64-2 ]
[ 873443-66-4 ]

Yield	Reaction Conditions	Operation in experiment
83.3%	With trichlorophosphate; at 135℃; for 10.0h;Heating in Parr bottle;	Example 9; This example illustrates a process for preparing 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine (Fig. VIII, Scheme I) A mixture of 40.00 g (131.0 mmol) of the appropriate pyridinium zwitter ion (prepared according to Example 5, 6 or 7) and 50.0 mL (82.3 g, 536 mmol) of phosphorus oxychloride was heated in a 300-mL Parr bottle at 135 C. for 10 hours. The reaction mixture was cooled to 25 C. and diluted with 75 mL of methylene chloride. The solution was transferred onto 350 g of ice. Additional methylene chloride (25 mL) was used to aid the transfer. The resulting mixture was stirred for 1 hour. The layers were separated, and the aqueous layer was extracted twice with 25 mL of methylene chloride and twice with 50 mL of toluene. The extracts were combined, dried (5.0 g Na2SO4), and filtered through 15 g of Filtrol on a 60-mL coarse sintered glass funnel. The flask and the solid were washed with 50 mL of toluene. The combined mother liquors were concentrated to afford 28.70 g (83.3%) of 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine as a near colorless solid (LC assay 100.7 wt %). An analytical sample was prepared by recrystallization from isopropanol and revealed: m.p. 129-131 C.; 1H NMR (CDCl3) δ 7.43 (dt, J=1.5 Hz, J=7 Hz, 1H), 7.37-7.31 (m, 2 H), 7.33 (s, 1H), 7.18 (dd, J=1.5 Hz, 8 Hz, 1H), 2.25 (s, 3H); 13C NMR (CDCl3) δ 159.1, 153.9, 153.3, 135.3, 134.1, 131.3, 130.7, 128.8, 126.7, 124.5, 113.7, 110.3, 20.0; IR (KBr) 3087, 2227, 1603, 1569, 1520, 1340 cm-1. Analytically calculated for C13H8C12N2: C, 59.34; H, 3.06; N, 10.65; Cl, 26.95. Found: C, 59.00; H, 3.05; N, 10.64; Cl, 27.76.

Reference： [1]Patent: US2006/14959,2006,A1 .Location in patent: Page/Page column 12

4
[ 873443-66-4 ]
2,6-dichloro-4-(2-methylphenyl)-3-pyridinecarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; at 100℃; for 3.0h;	Example 22; This example illustrates a process for preparing 2,6-dichloro-4-(2-methylphenyl) -3-pyridinecarboxamide. A mixture of <strong>[873443-66-4]3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine</strong> (15.00 g, 57.0 mmol), and 15 mL of concentrated sulfuric acid was heated at 100 C. for 3 hours. The mixture was cooled and quenched with 150 mL of H2O. The mixture was then extracted three times with ethyl acetate. The organic layers were combined, washed twice with 50 mL of H20, dried (MgSO4), filtered, and concentrated to afford 11.99 g of near-colorless solid. An analytical sample was prepared by recrystallization from toluene and revealed: m.p. 154-156 C.; 1HNMR (CDCl3) 6 7.34 (dt, J=1.5 Hz, J=7.5 Hz, 1H), 7.27 (d, J=7.5 Hz, 1H), 7.23 (t, J=8 Hz, 1H), 7.20 (s, 1H), 7.12 (dd, J =1 Hz, J =7.5 Hz, 1IH), 5.76 (br, 1H), 5.53 (br, 1H), 2.18 (s, 3H); 13C NMR (CDC13) 6 166.0, 153.4, 150.6, 147.4, 135.4, 135.3, 130.9, 129.7, 128.5, 126.1, 124.5, 95.0, 20.4; IR (KBr) 3391, 3303, 3167, 2360, 2350-2340, 1685, 1565, 1525 cm31 1.Elemental analytically calculated for C13H10Cl2N2O: C, 55.54; H, 3.59; N, 9.96. Found: C, 55.51; H, 3.57; N, 9.81.

Reference： [1]Patent: US2006/14959,2006,A1 .Location in patent: Page/Page column 15
[2]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

5
5'-cyano-1',2',3',4'-tetrahydro-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium inner salt [ No CAS ]
[ 873443-66-4 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

6
[ 873443-66-4 ]
[ 290296-68-3 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166
[2]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

7
[ 873443-66-4 ]
[ 342417-06-5 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166
[2]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

8
[ 873443-66-4 ]
[ 342417-01-0 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

9
[ 873443-66-4 ]
[ 342417-02-1 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

10
[ 873443-66-4 ]
[ 290297-25-5 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

11
[ 873443-66-4 ]
[ 290297-26-6 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

12
[ 873443-66-4 ]
5-cyano-4-(2-methylphenyl)-2-(4-morpholinyl)pyridine [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

13
[ 873443-66-4 ]
5-cyano-4-(2-methylphenyl)-2-(4-methylpiperazinyl)pyridine [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

14
[ 873443-66-4 ]
C₁₇H₁₉N₃O₅S [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

15
[ 873443-66-4 ]
2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-3-pyridinecarboxamide [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

16
[ 873443-66-4 ]
[ 342417-07-6 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166
[2]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

17
[ 873443-66-4 ]
[ 290297-36-8 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166
[2]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

18
[ 110-91-8 ]
[ 873443-66-4 ]
[ 873443-68-6 ]
C₁₇H₁₆ClN₃O [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

19
[ 109-01-3 ]
[ 873443-66-4 ]
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine [ No CAS ]
C₁₈H₁₉ClN₄ [ No CAS ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

20
[ 529-20-4 ]
[ 873443-66-4 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

21
[ 70625-63-7 ]
[ 873443-66-4 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 1157 - 1166

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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 873443-66-4 ] {[proInfo.proName]}

Quality Control of [ 873443-66-4 ]

Related Doc. of [ 873443-66-4 ]

Product Details of [ 873443-66-4 ]

Calculated chemistry of [ 873443-66-4 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 873443-66-4 ]

Application In Synthesis of [ 873443-66-4 ]

[ 873443-66-4 ] Synthesis Path-Upstream 1~4

[ 873443-66-4 ] Synthesis Path-Downstream 1~21

Related Functional Groups of [ 873443-66-4 ]

Aryls

Chlorides

Nitriles

Related Parent Nucleus of [ 873443-66-4 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 873443-66-4 ]

Related Parent Nucleus of
[ 873443-66-4 ]