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Chemical Structure| 873566-74-6 Chemical Structure| 873566-74-6

Structure of 873566-74-6

Chemical Structure| 873566-74-6

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Pogostin, Brett H ; Wu, Samuel X ; Swierczynski, Michael J ; Pennington, Christopher ; Li, Si-Yang ; Vohidova, Dilrasbonu , et al.

Abstract: Maintaining safe and potent drug levels in vivo is challenging. Multidomain peptides assemble into supramolecular hydrogels with a well-defined, highly porous nanostructure that makes them attractive for . However, their ability to extend release is typically limited by rapid drug diffusion. Here, to overcome this challenge, we present self-assembling boronate ester release (SABER) multidomain peptides capable of engaging in dynamic covalent bonding with payloads containing . As examples, we demonstrate that SABER hydrogels can prolong the release of boronic acid-containing small-molecule drugs and boronic acid-modified biologics such as insulin and antibodies. Pharmacokinetic studies reveal that SABER hydrogels extend the therapeutic effect of from days to weeks, preventing Mycobacterium tuberculosis growth compared with oral administration in an infection model. Similarly, SABER hydrogels extended insulin activity, maintaining normoglycemia for 6 days in diabetic mice after a single injection. These results suggest that SABER hydrogels present broad potential for clinical translation.

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Product Details of [ 873566-74-6 ]

CAS No. :873566-74-6
Formula : C6H7BFNO2
M.W : 154.93
SMILES Code : NC1=CC(B(O)O)=C(F)C=C1
MDL No. :MFCD03411555

Safety of [ 873566-74-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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