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CAS No. : | 874-77-1 | MDL No. : | MFCD03840696 |
Formula : | C7H13N3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XCUQQNRWWCWVOP-UHFFFAOYSA-N |
M.W : | 139.20 | Pubchem ID : | 10582860 |
Synonyms : |
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P280-P301+P310-P311 | UN#: | 3439 |
Hazard Statements: | H301+H311+H331 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 1 h; | 0086] Step 5. To a stirred suspension of lithium aluminum hydride (3.3 g, 87 mmol) in dry THF (100 mL), cooled to 0 °C, a solution of 2-(4-methylpiperazin-l-yl)acetonitrile (11.2 g, 80.4 mmol) in dry THF (300 mL) was slowly added. The mixture was stirred at room temperature for 1 h. The mixture was cooled in an ice bath, then H20 (3.3 mL) and a 20percent NaOH solution (3.3 mL) was added in sequence. After stirring for 20 min, the mixture was filtered and the solvent evaporated. The residue was dissolved in ethyl acetate and dried over anhydrous sodium sulfate. The solvent was evaporated to dryness to give 2-(4-methylpiperazin-l-yl)ethanamine (1.15 g, 99 percent) as an oil. 1H NMR (400 MHz, CDC13) δ: 2.21 (s, 3H), 2.20-2.60 (m, 10H), 2.71 (t, J = 6.0 Hz, 2H). |
7% | With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 20℃; for 20 h; | To an ice-cooled suspension of LiAlH4 (0.626 g, 16.50 mmol) in dry diethyl ether (18 mL) a solution of 23 (2.09 g, 15.00 mmol) in dry diethyl ether (27 mL) and THF (27 mL) was added dropwise. After 1 h, the ice-bath was removed and the reaction batch was stirred overnight at ambient temperature in an atmosphere of Ar. Subsequently the chemical reaction was quenched cautiously with 20percent aqueous NaOH and the mixture was stirred for 20 min. The solid was filtered off and the solvent was evaporated in vacuo giving 26 [0.150 g (7percent)] as a colourless oil. NMR data coincide with literature. |
4.74% | Stage #1: With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 24 h; Stage #2: With sodium hydroxide In tetrahydrofuran; diethyl ether at 0℃; for 0.333333 h; |
[000703] Step 2: 4 g of the product obtained in step 1 (0.028 moles) was dissolved in a 1:1 mixture of Tetrahydrofuran:Diethylether and was added drop wise to a suspension of lithium aluminium hydride (3.2 g) in diethylether (20 mL) at 0°C. [000704] The reaction was stirred at room temperature for 24 hours, cooled to 0°C and 10 mL of NaOH 6N was added and mixture stirred for 20 minutes. The solid was removed by filtration and filtrate was evaporated to give the title compound (208) in 4.74percent yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With potassium carbonate In acetonitrile at 20℃; | 1.4 [0085] Step 4. A mixture of 1-methylpiperazine (9.0 g, 90 mmol), acetonitrile (60 mL), K2CC"3 (60.0 g, 430.0 mmol), and 2-chloroacetonitrile (7.2 g, 95 mmol) was stirred at room temperature overnight. Ethyl acetate (100 mL) was added, and the suspension was filtered. The filtrate was concentrated in vacuo to give 2-(4-methylpiperazin-l-yl)acetonitrile as black oil (1.25 g, 99%), which was used directly in the subsequent step. |
96% | With potassium carbonate In acetonitrile for 20h; Ambient temperature; | |
73% | With potassium carbonate In acetonitrile at 20℃; for 20h; | 6.2.7. Synthesis of 2-(4-methylpiperazin-1-yl)acetonitrile (23) 1-Methylpiperazine (2.00 g, 20.00 mmol) and K2CO3 (13.13 g,95.00 mmol) were suspended in acetonitrile (20 mL). To this mixture, chloroacetonitrile (1.74 g, 23.00 mmol) was added dropwise and then the reaction batch was stirred at ambient temperature for 20 h. Diethyl ether (18 mL) was added and the solid was filtered off. The solvent was evaporated in vacuo giving 23 [2.03 g (73%)] as orange residue. Melting point and NMR data were in accordance with literature data. |
5.18% | With potassium carbonate In acetonitrile for 96h; | 189.1 Example 189: Synthesis of 2-(4-methyl-piperazin-1-yl)ethanamide. (208) [000702] Step 1: A solution of N-methyl-piperazine (0.018 moles, 1.99 mL), 1.4 mL of chloroacetonitrile (0.022 moles, 1.193 g/mL) and potassium carbonate (K2CO3) (0.086 moles, 12 g) in acetonitrile (CAN) (18 mL) is stirred for 96 hours at room temgeneerperature. The reaction was filtered under a vacuum and the filtrate was evaporated. Desired product was obtained in 5.18% yield. |
With potassium carbonate In acetonitrile for 72h; | 27.A Preparation 27 2- (4-Methyl-piperazin-1-yl)-ethvlamine Step A; A solution of 0.90 g of 4-methylpiperazine, 0.830 g of chloroacetonitrile, and 6.0 g of potassium carbonate in acetonitrile (9 mL) was stirred for 72 h. The reaction mixture was filtered and the filtrate was concentrated to provide a yellow solid. | |
With potassium carbonate In acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 1h; | 0086] Step 5. To a stirred suspension of lithium aluminum hydride (3.3 g, 87 mmol) in dry THF (100 mL), cooled to 0 °C, a solution of 2-(4-methylpiperazin-l-yl)acetonitrile (11.2 g, 80.4 mmol) in dry THF (300 mL) was slowly added. The mixture was stirred at room temperature for 1 h. The mixture was cooled in an ice bath, then H20 (3.3 mL) and a 20percent NaOH solution (3.3 mL) was added in sequence. After stirring for 20 min, the mixture was filtered and the solvent evaporated. The residue was dissolved in ethyl acetate and dried over anhydrous sodium sulfate. The solvent was evaporated to dryness to give 2-(4-methylpiperazin-l-yl)ethanamine (1.15 g, 99 percent) as an oil. 1H NMR (400 MHz, CDC13) delta: 2.21 (s, 3H), 2.20-2.60 (m, 10H), 2.71 (t, J = 6.0 Hz, 2H). |
7% | With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20℃; for 20h; | To an ice-cooled suspension of LiAlH4 (0.626 g, 16.50 mmol) in dry diethyl ether (18 mL) a solution of 23 (2.09 g, 15.00 mmol) in dry diethyl ether (27 mL) and THF (27 mL) was added dropwise. After 1 h, the ice-bath was removed and the reaction batch was stirred overnight at ambient temperature in an atmosphere of Ar. Subsequently the chemical reaction was quenched cautiously with 20percent aqueous NaOH and the mixture was stirred for 20 min. The solid was filtered off and the solvent was evaporated in vacuo giving 26 [0.150 g (7percent)] as a colourless oil. NMR data coincide with literature. |
4.74% | [000703] Step 2: 4 g of the product obtained in step 1 (0.028 moles) was dissolved in a 1:1 mixture of Tetrahydrofuran:Diethylether and was added drop wise to a suspension of lithium aluminium hydride (3.2 g) in diethylether (20 mL) at 0°C. [000704] The reaction was stirred at room temperature for 24 hours, cooled to 0°C and 10 mL of NaOH 6N was added and mixture stirred for 20 minutes. The solid was removed by filtration and filtrate was evaporated to give the title compound (208) in 4.74percent yield. |
Step B; The product from Step A was dissolved in a 1: 1 mixture of ether/THF and was added to a suspension of 330 mg of LAH in ether (10 mL) at 0 C. The reaction was stirred at room temperature for 24 h, cooled to 0 C, and 5 mL of a solution of 6.0 N sodium hydroxide was added with stirring for 20 min. The solids were removed by filtration, and the filtrate was concentrated, dissolved in ether, dried over sodium sulfate, filtered, and concentrated to give the title compound as a light yellow oil. MS (M+H) + = 144.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Rk. mit H2, Rh/Al-Oxid (2.5 at, Hydrierung), ethanol. NH3 -> 2-(4-Methyl-1-piperazino)-ethylamin; | ||
Rk. mit H2 -> 1-Methyl-4-(2-amino-ethyl)-piperazin, 2,2'-Bis-(4-methyl-piperazino)-diethylamin; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Formaldehyd, NaHSO3, 1) 1-Methylpiperazin, 2) KCN; | ||
1-Methyl-piperazin, Monochloracetonitril, Na2CO3, sd. Bzl.; Ausb.: 64percent; | ||
1-Methyl-piperazin, HO-CH2-CN; |
1-Methyl-piperazin, CH2-Hlg.-CN, Na2CO3, Bzl., Δ (Siedetemp., 6 h); Ausb.: 80percent; | ||
Chloracetonitril, entspr. Amin; | ||
entspr. Amin, ClCH2CN; | ||
1-Methyl-piperazin, Chloracetonitril, (DMF, K2CO3, 20grad, 15 Std.); | ||
(yield)68percent; | ||
ClCH2CN, Methylpiperazin; | ||
4-Methylpiperazin, Chloracetonitril/EtOH, reflux; | ||
N-Methylpiperazin; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With antimonypentachloride In dichloromethane at -60 - 23℃; for 2.16667h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With antimonypentachloride In dichloromethane at -60 - 23℃; for 2.16667h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With antimonypentachloride In dichloromethane at -60 - 23℃; for 2.16667h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With potassium carbonate In acetonitrile for 75h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With pyridine; hydrogen sulfide; triethylamine | |
35% | With hydrogen sulfide; triethylamine In N,N-dimethyl-formamide at 70℃; for 1h; | 29 4-Methylpiperazin-1-yl)acetonitrile (1.03 g, 7.42 mmol) was added to a mixture of DMF (5 mL) and triethylamine (2 mL). Hydrogen sulfide gas was bubbled into the solution until the solution was dark green. The solution was then heated at 70° C. for 1 h. Excess hydrogen sulfide was removed from the system by bubbling nitrogen into the solution and then the volatiles were removed in vacuo to afford brown crystals. These crystals were triturated with ethanol to afford 2-(4-methylpiperazin-1-yl)ethanethioamide as very pale brown crystals (0.455 g, 2.63 mmol, 35% yield). 1H NMR (400 MHz; CDCl3): 2.29 (s, 3H); 2.38-2.66 (m, 8H); 3.44 (s, 2H); 7.72 (br s, 1H); 8.76 (br s, 1H); GCMS for C7H15N3S: 173 (M+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dimethyl sulfoxide at 25℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: methanol; H2O / 25 °C 2: dimethylsulfoxide / 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 37 percent / H2S; Et3N; pyridine 2: 85 percent / tetrahydrofuran / 5 h / 70 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 37 percent / H2S; Et3N; pyridine 2: 85 percent / tetrahydrofuran / 5 h / 70 °C 3: 7 percent / HATU; diisopropylethylamine / dimethylformamide / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 18 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 18 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 99 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: Et3N / tetrahydrofuran / 24 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h 2.2: 20 °C 3.1: hydrogenchloride / methanol / 0.17 h / -78 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h 2.2: 2 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C 2.2: 12 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h 2.2: 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
405 mg | With hydroxylamine In ethanol; water at 20℃; for 18h; | 32 A mixture (4-methylpiperazin-1-yl)acetonitrile (400 mg), hydroxylamine (50% aqueous solution, 2.0 mL) and ethanol (10.0 mL), was stirred at room temperature for 18 hours. The reaction mixture was evaporated to dryness to give a crystalline solid that was washed with hexane and dried under vacuum to give N-hydroxy-2-(4-methylpiperazin-1-yl)ethanimidamide (405 mg). 1H-NMR (400 MHz; CDCl3): 5.19 (br s, 3H), 3.00 (s, 2H), 2.75-2.28 (br m, 8H), 2.70 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: hydroxylamine / ethanol; water / 18 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 60 °C / Molecular sieve 2.2: 1 h / 90 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 20 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 21 h / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With potassium phosphate; copper diacetate In N,N-dimethyl-formamide at 130℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51 %Chromat. | With 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); nickel(II) acetate tetrahydrate; sodium carbonate In 1,4-dioxane at 150℃; for 12h; Inert atmosphere; |
Tags: 874-77-1 synthesis path| 874-77-1 SDS| 874-77-1 COA| 874-77-1 purity| 874-77-1 application| 874-77-1 NMR| 874-77-1 COA| 874-77-1 structure
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Precautionary Statements-General | |
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P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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