Alternatived Products of [ 876442-90-9 ]
Product Details of [ 876442-90-9 ]
CAS No. : | 876442-90-9 |
MDL No. : | MFCD26406213 |
Formula : |
C16H13BO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | XDKCHGWZDWHBQO-UHFFFAOYSA-N |
M.W : |
248.08
|
Pubchem ID : | 57539613 |
Synonyms : |
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Safety of [ 876442-90-9 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
Hazard Statements: | H302 |
Packing Group: | N/A |
GHS Pictogram: |
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Application In Synthesis of [ 876442-90-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 876442-90-9 ]
- 1
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[ 38557-72-1 ]

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[ 876442-90-9 ]

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[ 1337916-19-4 ]
Yield | Reaction Conditions | Operation in experiment |
82% |
With sodium carbonate;bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile;Inert atmosphere; Microwave irradiation; |
Step 4: Synthesis of 3,5-Dimethyl-2-(6-phenylnaphthalen-2-yl)pyrazine (abbreviation: Hdm6p2npr)First, into a recovery flask equipped with a reflux pipe were placed 0.24 g of <strong>[38557-72-1]2-chloro-3,5-dimethylpyrazine</strong>, 0.41 g of 6-phenylnaphthalene-2-boronic acid, 0.18 g of sodium carbonate, 0.008 g of bis(triphenylphosphine)palladium(II) dichloride (abbreviation: Pd(PPh3)2Cl2), 10 mL of water, and 10 mL of acetonitrile, and the air in the flask was replaced with argon. This reaction container was irradiated with microwaves (2.45 GHz, 100 W) for 30 minutes, so that heating was performed. Then, the reaction container was cooled to 50 C. or less. Water was added to the reaction solution, and the organic layer was extracted with dichloromethane. The obtained organic layer was washed with water and dried with magnesium sulfate. The solution which had been dried was filtered. The solvent of this solution was distilled, whereby Hdm6p2npr, which is the pyrazine derivative to be produced, was obtained (as a white powder in 82% yield). Note that the microwave irradiation was performed using a microwave synthesis system (Discover, manufactured by CEM Corporation). The synthesis scheme of Step 4 is illustrated in the following (d-4). |