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Chemical Structure| 877317-26-5 Chemical Structure| 877317-26-5

Structure of 877317-26-5

Chemical Structure| 877317-26-5

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Product Details of [ 877317-26-5 ]

CAS No. :877317-26-5
Formula : C16H22N2O5
M.W : 322.36
SMILES Code : O=C(CNC(OCC1=CC=CC=C1)=O)CNC(OC(C)(C)C)=O
MDL No. :MFCD30607319
InChI Key :QCOPAKPZXWRKIO-UHFFFAOYSA-N
Pubchem ID :57532015

Safety of [ 877317-26-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 877317-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 877317-26-5 ]

[ 877317-26-5 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 877317-25-4 ]
  • [ 877317-26-5 ]
YieldReaction ConditionsOperation in experiment
73% With pyridinium chlorochromate; In dichloromethane; at 20 - 25℃; Compound 22C (2.78g, 8.57 mmol) was dissolved inmethylene chloride (100 ml). PCC (4.62 g, 21.4 mmol) and celite (4.6 g)were added and the reaction mixture was stirred at 25 C overnight. Another0.5 eq. of PCC (923 mg, 4.3 mmol) was added and it was stirred for 3 hr atroom temperature. The solid was filtered off and the resulting solution wasconcentrated and purified via sgc (50% EtOAc/Hexanes) to give 1.86 g (73%)of compound 22D.
  • 2
  • [ 877317-26-5 ]
  • [ 877317-27-6 ]
YieldReaction ConditionsOperation in experiment
64% With ammonium carbonate; potassium cyanide; In ethanol; water; at 80℃; Compound 22D (1.86, 5.8 mmol), KCN (0.56 g, 8.65 mmol),and (NH4)2CO3 (1.66 g, 17.3 mmol) were suspended in a mixture of EtOH (20ml) and water (20 ml). The solution was stirred at 80 C overnight. Aftercooling down, EtOH was removed. The solid was filtered and washed withwater three times. The solid was dried under vacuum to give compound 22E(1.45g,64%).
  • 3
  • [ 877317-26-5 ]
  • C9H20N2O3 [ No CAS ]
  • 4
  • [ 877317-26-5 ]
  • C20H30N4O6S2 [ No CAS ]
  • 5
  • [ 877317-26-5 ]
  • [ 75-16-1 ]
  • C17H26N2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% In tetrahydrofuran; at -65 - 20℃; for 2.5h;Inert atmosphere; A solution of Example 302A (6.77g, 21 mmol) in THF (200 mL) under N2 atmosphere was cooled to -65 C. MeMgBr (21 mL, 63.1 mmol, 3M in THF) was added dropwise, then stirred at -65 C for 0.5 h. The reaction was warmed to r.t. for 2 h, quenched by addition of water (200 mL). After extraction with EtOAc (200 mL x 2), the combined organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluted with petroleum ether/EtOAc=3/l) to give the desired product Example 302B (4 g, yield 56%) as a yellow oil. LCMS [MTH]+ = 339
 

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