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Chemical Structure| 87980-84-5 Chemical Structure| 87980-84-5

Structure of 87980-84-5

Chemical Structure| 87980-84-5

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Product Details of [ 87980-84-5 ]

CAS No. :87980-84-5
Formula : C8H14F3N3O
M.W : 225.21
SMILES Code : O=C(NCCN1CCNCC1)C(F)(F)F

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Application In Synthesis of [ 87980-84-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 87980-84-5 ]

[ 87980-84-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42881-66-3 ]
  • [ 87980-84-5 ]
  • [ 774609-84-6 ]
YieldReaction ConditionsOperation in experiment
73% In DMF (N,N-dimethyl-formamide); at 20 - 100℃; for 18h; To solution of 1,1, 1-trifluoro-N-(2-piperazin-1-ylethyl) acetamide (2.3 g, 10.0 mmole) in DMF (5 mL) at RT was added 4-BROMO-6-METHOXYQUINOLINE (2.0 g, 8. 4 mmole) and triethylamine (0. 86 mL, 8.4 mmole). After 18 hr at 100 C, the reaction solution was concentrated under vacuum and purified on silica gel (CHC13/MEOH, 9: 1, containing 5% NH40H) to give the title compound as an off-white solid (2.32 g, 73 %): LC-MS (ES) m/e 383 (M + H) +.
 

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