Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 880339-31-1 Chemical Structure| 880339-31-1

Structure of 880339-31-1

Chemical Structure| 880339-31-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Santi, Athena B ; Muzzio, Nicolas ; Gomez, Amanda ; Romero, Gabriela ;

Abstract: Neuropathic pain is a chronic condition that often requires long-term management, with opioids frequently being the primary option for severe pain relief. Capsaicin, a natural analgesic, holds promise for chronic pain management but is limited by its hydrophobicity, low tissue affinity, and short half-life. In this study, we developed a magnetic field-responsive nanodrug for the on-demand delivery of capsaicin, overcoming these limitations. We utilize iron oxide magnetic nanoparticles (MNPs) functionally coated with thermoresponsive poly(oligo (ethylene glycol) methyl ether methacrylate) (POEGMA). POEGMA nanocoatings on MNPs serve as capsaicin reservoirs. Upon alternating magnetic field (AMFs) exposure, MNPs dissipate heat locally, which triggers the thermodynamic response of their POEGMA nanocoating for capsaicin release. We studied the passive and AMFs-controlled release of capsaicin from MNPs. Then, we investigated the nanodrug for regulating the pain receptor TRPV1, endogenously expressed in primary rat hippocampal neurons, using calcium ion influx as an ion channel activity indicator. Finally, we assessed the biological impact of the nanodrug through cell viability and reactive oxygen species production. We showed that AMFs-induced release of one dose of capsaicin enhances TRPV1 receptors in more than 75% of hippocampal neurons, which would translate to an increased pain sensitivity. However, tonic capsaicin treatment (more than 3 doses of AMFs-induced release) desensitizes TRPV1 in more than 90% of neurons, which would result in analgesic effects. Importantly, the nanotherapy has no detrimental effects on neuronal health. The nanodrug developed here offers a promising mechanism-driven alternative for chronic pain management by enabling wireless and on-demand control of pain receptors.

Keywords: nanodrug ; magnetic nanoparticles ; alternating magnetic fields ; capsaicin ; TRPV1

Purchased from AmBeed:

Alternative Products

Product Details of [ 880339-31-1 ]

CAS No. :880339-31-1
Formula : C13H27BrO5Si
M.W : 371.34
SMILES Code : CC(C)(Br)C(OCCC[Si](OCC)(OCC)OCC)=O
MDL No. :MFCD05865083
InChI Key :HRBDELVBHOGZRM-UHFFFAOYSA-N
Pubchem ID :53230135

Safety of [ 880339-31-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338+P310-P332+P313-P362-P403+P233-P405-P501
Class:8
UN#:1760
Packing Group:
 

Historical Records

Technical Information

Categories