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Chemical Structure| 88207-45-8 Chemical Structure| 88207-45-8

Structure of 88207-45-8

Chemical Structure| 88207-45-8

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Product Details of [ 88207-45-8 ]

CAS No. :88207-45-8
Formula : C14H10BrN
M.W : 272.14
SMILES Code : BrC1=CC=CC=C1C(N2)=CC3=C2C=CC=C3
MDL No. :MFCD05224893

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Application In Synthesis of [ 88207-45-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88207-45-8 ]

[ 88207-45-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 88207-45-8 ]
  • [ 771-15-3 ]
  • [ 1417570-23-0 ]
  • 2
  • [ 88207-45-8 ]
  • [ 33105-81-6 ]
  • [ 239-43-0 ]
  • 3
  • [ 88207-45-8 ]
  • [ 32566-01-1 ]
  • 4
  • [ 88207-45-8 ]
  • [ 599-91-7 ]
  • 2-(2-bromophenyl)-1-n-propyl-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% In a nitrogen-spished 100 ml three-necked bottle, 4.07 g of 2-(2'-bromophenyl)-1H-indole was weighed.(15 mmol), add 40 ml of dimethylformamide, stir well. Another 4.2 g of potassium hydroxide (75 mmol) was added and reacted for 5-24 hours. As most of the potassium hydroxide dissolved, a thick cloudy solution formed, and 3.3 ml of n-propyl p-toluenesulfonate (16.5 mmol) was added at room temperature. Under the reaction for 24 hours. Point plate monitoring, when the reaction of raw materials is complete, stop the reaction, add 50 ml of water and 50 ml of methylene chloride to the system, and then add 100 ml of water and dichloromethane to extract, combine the organic phase, anhydrous sodium sulfate dry. Purification by column chromatography gave 3.23 g of 2-(2-bromophenyl)-1-n-propyl-1H-indole intermediate. The yield was 69percent and the reaction was directly put into the next step.
 

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