Home Cart 0 Sign in  

[ CAS No. 882738-24-1 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 882738-24-1
Chemical Structure| 882738-24-1
Structure of 882738-24-1 *Storage: {[proInfo.prStorage]}

Quality Control of [ 882738-24-1 ]

Related Doc. of [ 882738-24-1 ]

SDS
Alternatived Products of [ 882738-24-1 ]
Alternatived Products of [ 882738-24-1 ]

Product Details of [ 882738-24-1 ]

CAS No. :882738-24-1MDL No. :MFCD04038489
Formula : C18H25NO4 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :319.40Pubchem ID :-
Synonyms :

Computed Properties of [ 882738-24-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 882738-24-1 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 882738-24-1 ]

  • Upstream synthesis route of [ 882738-24-1 ]
  • Downstream synthetic route of [ 882738-24-1 ]

[ 882738-24-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 882738-24-1 ]
  • [ 138007-24-6 ]
YieldReaction ConditionsOperation in experiment
91% With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; [0510] To a 3 L flask under nitrogen was charged Pd on C,wet, Degussa (10percent Pd, 50percent water) (8.120 g, 76.30 mmol)then EtOAc (1.706 L). The mixture was degassed viaN2/vacuum cycles (3x), then a solution of 1-benzyl-4-tertbutylpiperidine- ,4-dicarboxylate 21 (243 .7 g, 7 63.0 mmol)in EtOAc (243.7 mL) was added. Mixture was stirred under ahydrogen atmosphere overnight. Hydrogen was replenishedand mixture was stirred for a further 3.5 hr. Methanol ( 60 mL)was added to aid dissolution of precipitate then filteredthrough celite, washing through with methanol. Filtrate concentratedin vacuo to leave a brown oil with a slight suspensionofawhite solid, 138.6 g. Solid removed by filtration, andwashed with minimal EtOAc. Filtrate was concentrated invacuo to leave desired product as a light brown oil (129 g,91 percent). 1H NMR (500 MHz, DMSO-d6) o2.88 (dt, 2H), 2.44(td, 2H), 2.23 (tt, lH), 1.69-1.64 (m, 2H) and 1.41-1.33 (m,11H).
76% With hydrogen In ethyl acetate at 20℃; for 8 h; To a solution of 1-benzyl 4-feτt-butyl piperidine-l,4-dicarboxylate in EtOAc (0.1 M), a catalytic amount of Pd/C (5 percent) was added and the atmosphere in the reaction vessel charged with H2 (1 atmosphere). The reaction mixture was stirred vigorously at RT for 8 h. The solution was filtered and the filtrate concentrated in vacuo to afford the title compound (76 percent); MS (ES+) m/z 186(M+H)+
Reference: [1] Patent: US2015/158872, 2015, A1, . Location in patent: Paragraph 0508; 0510
[2] Patent: WO2006/38039, 2006, A1, . Location in patent: Page/Page column 17; 29
[3] Patent: WO2015/65866, 2015, A1, . Location in patent: Page/Page column 32
Historical Records